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Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages.
Brain Cogn. 2006 Jun; 61(1):25-39.BC

Abstract

Deficits in 'executive function' (EF) are characteristic of several clinical disorders, most notably Autism Spectrum Disorders (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD). In this study, age- and IQ-matched groups with ASD, ADHD, or typical development (TD) were compared on a battery of EF tasks tapping three core domains: response selection/inhibition, flexibility, and planning/working memory. Relations between EF, age and everyday difficulties (rated by parents and teachers) were also examined. Both clinical groups showed significant EF impairments compared with TD peers. The ADHD group showed greater inhibitory problems on a Go-no-Go task, while the ASD group was significantly worse on response selection/monitoring in a cognitive estimates task. Age-related improvements were clearer in ASD and TD than in ADHD. At older (but not younger) ages, the ASD group outperformed the ADHD group, performing as well as the TD group on many EF measures. EF scores were related to specific aspects of communicative and social adaptation, and negatively correlated with hyperactivity in ASD and TD. Within the present groups, the overall findings suggested less severe and persistent EF deficits in ASD (including Asperger Syndrome) than in ADHD.

Authors+Show Affiliations

MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK. spjwfgh@iop.kcl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16682102

Citation

Happé, Francesca, et al. "Executive Function Deficits in Autism Spectrum Disorders and Attention-deficit/hyperactivity Disorder: Examining Profiles Across Domains and Ages." Brain and Cognition, vol. 61, no. 1, 2006, pp. 25-39.
Happé F, Booth R, Charlton R, et al. Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages. Brain Cogn. 2006;61(1):25-39.
Happé, F., Booth, R., Charlton, R., & Hughes, C. (2006). Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages. Brain and Cognition, 61(1), 25-39.
Happé F, et al. Executive Function Deficits in Autism Spectrum Disorders and Attention-deficit/hyperactivity Disorder: Examining Profiles Across Domains and Ages. Brain Cogn. 2006;61(1):25-39. PubMed PMID: 16682102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages. AU - Happé,Francesca, AU - Booth,Rhonda, AU - Charlton,Rebecca, AU - Hughes,Claire, Y1 - 2006/05/06/ PY - 2005/12/09/accepted PY - 2006/5/10/pubmed PY - 2006/8/4/medline PY - 2006/5/10/entrez SP - 25 EP - 39 JF - Brain and cognition JO - Brain Cogn VL - 61 IS - 1 N2 - Deficits in 'executive function' (EF) are characteristic of several clinical disorders, most notably Autism Spectrum Disorders (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD). In this study, age- and IQ-matched groups with ASD, ADHD, or typical development (TD) were compared on a battery of EF tasks tapping three core domains: response selection/inhibition, flexibility, and planning/working memory. Relations between EF, age and everyday difficulties (rated by parents and teachers) were also examined. Both clinical groups showed significant EF impairments compared with TD peers. The ADHD group showed greater inhibitory problems on a Go-no-Go task, while the ASD group was significantly worse on response selection/monitoring in a cognitive estimates task. Age-related improvements were clearer in ASD and TD than in ADHD. At older (but not younger) ages, the ASD group outperformed the ADHD group, performing as well as the TD group on many EF measures. EF scores were related to specific aspects of communicative and social adaptation, and negatively correlated with hyperactivity in ASD and TD. Within the present groups, the overall findings suggested less severe and persistent EF deficits in ASD (including Asperger Syndrome) than in ADHD. SN - 0278-2626 UR - https://www.unboundmedicine.com/medline/citation/16682102/Executive_function_deficits_in_autism_spectrum_disorders_and_attention_deficit/hyperactivity_disorder:_examining_profiles_across_domains_and_ages_ DB - PRIME DP - Unbound Medicine ER -