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Transport of messenger RNA from the nucleus to the cytoplasm.
Curr Opin Cell Biol. 2006 Jun; 18(3):299-306.CO

Abstract

All movement of molecules and macromolecules between the cytoplasm and the nucleus takes place through nuclear pore complexes (NPCs), very large macromolecular complexes that are the only channels connecting these compartments. mRNA export is mediated by multiple, highly conserved protein factors that couple steps of nuclear pre-mRNA biogenesis to mRNA transport. Mature messenger ribonucleoproteins (mRNPs) diffuse from sites of transcription to NPCs, although some active genes are positioned at the nuclear periphery where they interact physically with components of NPCs. As properly processed mRNPs translocate through the pore, certain mRNP proteins are removed, probably through the enzymatic action of the DEAD-box helicase Dbp5, which binds to Nup159 and Gle1, components of the cytoplasmic filaments of the NPC. Gle1 and the phosphoinositide IP6 activate Dbp5's ATPase activity in vitro and this could provide critical spatial regulation of Dbp5 activity in vivo.

Authors+Show Affiliations

Department of Biochemistry, Dartmouth Medical School Hanover, NH 03755, USA. charles.cole@dartmouth.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16682182

Citation

Cole, Charles N., and John J. Scarcelli. "Transport of Messenger RNA From the Nucleus to the Cytoplasm." Current Opinion in Cell Biology, vol. 18, no. 3, 2006, pp. 299-306.
Cole CN, Scarcelli JJ. Transport of messenger RNA from the nucleus to the cytoplasm. Curr Opin Cell Biol. 2006;18(3):299-306.
Cole, C. N., & Scarcelli, J. J. (2006). Transport of messenger RNA from the nucleus to the cytoplasm. Current Opinion in Cell Biology, 18(3), 299-306.
Cole CN, Scarcelli JJ. Transport of Messenger RNA From the Nucleus to the Cytoplasm. Curr Opin Cell Biol. 2006;18(3):299-306. PubMed PMID: 16682182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transport of messenger RNA from the nucleus to the cytoplasm. AU - Cole,Charles N, AU - Scarcelli,John J, Y1 - 2006/05/08/ PY - 2006/03/14/received PY - 2006/04/10/accepted PY - 2006/5/10/pubmed PY - 2006/7/27/medline PY - 2006/5/10/entrez SP - 299 EP - 306 JF - Current opinion in cell biology JO - Curr Opin Cell Biol VL - 18 IS - 3 N2 - All movement of molecules and macromolecules between the cytoplasm and the nucleus takes place through nuclear pore complexes (NPCs), very large macromolecular complexes that are the only channels connecting these compartments. mRNA export is mediated by multiple, highly conserved protein factors that couple steps of nuclear pre-mRNA biogenesis to mRNA transport. Mature messenger ribonucleoproteins (mRNPs) diffuse from sites of transcription to NPCs, although some active genes are positioned at the nuclear periphery where they interact physically with components of NPCs. As properly processed mRNPs translocate through the pore, certain mRNP proteins are removed, probably through the enzymatic action of the DEAD-box helicase Dbp5, which binds to Nup159 and Gle1, components of the cytoplasmic filaments of the NPC. Gle1 and the phosphoinositide IP6 activate Dbp5's ATPase activity in vitro and this could provide critical spatial regulation of Dbp5 activity in vivo. SN - 0955-0674 UR - https://www.unboundmedicine.com/medline/citation/16682182/Transport_of_messenger_RNA_from_the_nucleus_to_the_cytoplasm_ DB - PRIME DP - Unbound Medicine ER -