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A vision of a world without polio: the OPV cessation strategy.
Biologicals 2006; 34(2):75-9B

Abstract

Once the eradication of wild poliovirus has been confirmed, the public health benefits of routine immunization with OPV will no longer outweigh the burden of disease either due to paralysis caused by OPV (vaccine associated paralytic polio), or by outbreaks caused by circulating vaccine-derived polioviruses. The eventual cessation of OPV use in routine immunization programmes worldwide will become necessary to assure a lasting eradication of polio. As the world moves towards polio eradication and its certification, preparations are therefore being intensified for OPV cessation, and the risk management framework for safe OPV cessation is being put in place. The framework includes bio-containment of all known poliovirus and potentially infected substances, development of an international stockpile of oral polio vaccine, ensuring a mechanism for continued global surveillance and response for polio after eradication has been certified, and national policies if countries decide to continue vaccinating with inactivated polio vaccine (IPV). It is ironic that the vaccine on which the world has depended for polio eradication will itself become a risk to eradication once the transmission of wild poliovirus has been interrupted. Final preparations for the eventual global and simultaneous cessation of OPV will require the same level of international cooperation and coordination that has brought the world to the verge of polio eradication.

Authors+Show Affiliations

World Health Organization, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland. heymannd@who.intNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16682224

Citation

Heymann, David L., et al. "A Vision of a World Without Polio: the OPV Cessation Strategy." Biologicals : Journal of the International Association of Biological Standardization, vol. 34, no. 2, 2006, pp. 75-9.
Heymann DL, Sutter RW, Aylward RB. A vision of a world without polio: the OPV cessation strategy. Biologicals. 2006;34(2):75-9.
Heymann, D. L., Sutter, R. W., & Aylward, R. B. (2006). A vision of a world without polio: the OPV cessation strategy. Biologicals : Journal of the International Association of Biological Standardization, 34(2), pp. 75-9.
Heymann DL, Sutter RW, Aylward RB. A Vision of a World Without Polio: the OPV Cessation Strategy. Biologicals. 2006;34(2):75-9. PubMed PMID: 16682224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A vision of a world without polio: the OPV cessation strategy. AU - Heymann,David L, AU - Sutter,Roland W, AU - Aylward,R Bruce, Y1 - 2006/05/08/ PY - 2006/5/10/pubmed PY - 2006/8/2/medline PY - 2006/5/10/entrez SP - 75 EP - 9 JF - Biologicals : journal of the International Association of Biological Standardization JO - Biologicals VL - 34 IS - 2 N2 - Once the eradication of wild poliovirus has been confirmed, the public health benefits of routine immunization with OPV will no longer outweigh the burden of disease either due to paralysis caused by OPV (vaccine associated paralytic polio), or by outbreaks caused by circulating vaccine-derived polioviruses. The eventual cessation of OPV use in routine immunization programmes worldwide will become necessary to assure a lasting eradication of polio. As the world moves towards polio eradication and its certification, preparations are therefore being intensified for OPV cessation, and the risk management framework for safe OPV cessation is being put in place. The framework includes bio-containment of all known poliovirus and potentially infected substances, development of an international stockpile of oral polio vaccine, ensuring a mechanism for continued global surveillance and response for polio after eradication has been certified, and national policies if countries decide to continue vaccinating with inactivated polio vaccine (IPV). It is ironic that the vaccine on which the world has depended for polio eradication will itself become a risk to eradication once the transmission of wild poliovirus has been interrupted. Final preparations for the eventual global and simultaneous cessation of OPV will require the same level of international cooperation and coordination that has brought the world to the verge of polio eradication. SN - 1045-1056 UR - https://www.unboundmedicine.com/medline/citation/16682224/A_vision_of_a_world_without_polio:_the_OPV_cessation_strategy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1045-1056(06)00043-1 DB - PRIME DP - Unbound Medicine ER -