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Asymptomatic Helicobacter pylori infection and iron deficiency are not associated with decreased growth among Alaska Native children aged 7-11 years.
Helicobacter. 2006 Jun; 11(3):159-67.H

Abstract

INTRODUCTION

Alaska Native children have high Helicobacter pylori infection and iron deficiency prevalences, and their average height-for-age is lower than US reference populations. During a clinical trial to determine the impact of H. pylori treatment on iron deficiency, we evaluated the effects of H. pylori infection and treatment on growth.

MATERIALS AND METHODS

We measured height and weight for children aged 7-11 years in western Alaska using village-based measuring devices. H. pylori infection was determined by urea breath test and iron deficiency using serum ferritin. Children with H. pylori infection and iron deficiency entered the treatment phase and received iron alone or iron plus triple therapy for H. pylori. Follow-up evaluations occurred at 2, 8, and 14 months. We evaluated the association between baseline H. pylori infection and growth; among children in the treatment phase, we also assessed the effect of H. pylori resolution on growth.

RESULTS

At baseline, 566 (87.1%) of 650 children were infected with H. pylori. Neither height and weight, nor body mass index differed by H. pylori infection status. Of 189 children in the treatment phase, 20 (10.6%) were uninfected at all three follow-up periods, and 54 (28.6%) were uninfected for one or two periods. Compared with continuously infected children, children in these two groups had little evidence of improvements in any of the measured growth outcomes.

CONCLUSIONS

H. pylori infection is not related to growth among Alaska Native children aged 7-11 years. Growth deficiency should not be considered an indication for H. pylori therapy.

Authors+Show Affiliations

US Centers for Disease Control and Prevention, Office of Workforce and Career Development, Epidemic Intelligence Service Officer, Alaska Division of Public Health, Anchorage, Alaska 99524, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16684263

Citation

Chimonas, Marc-Andre R., et al. "Asymptomatic Helicobacter Pylori Infection and Iron Deficiency Are Not Associated With Decreased Growth Among Alaska Native Children Aged 7-11 Years." Helicobacter, vol. 11, no. 3, 2006, pp. 159-67.
Chimonas MA, Baggett HC, Parkinson AJ, et al. Asymptomatic Helicobacter pylori infection and iron deficiency are not associated with decreased growth among Alaska Native children aged 7-11 years. Helicobacter. 2006;11(3):159-67.
Chimonas, M. A., Baggett, H. C., Parkinson, A. J., Muth, P. T., Dunaway, E., & Gessner, B. D. (2006). Asymptomatic Helicobacter pylori infection and iron deficiency are not associated with decreased growth among Alaska Native children aged 7-11 years. Helicobacter, 11(3), 159-67.
Chimonas MA, et al. Asymptomatic Helicobacter Pylori Infection and Iron Deficiency Are Not Associated With Decreased Growth Among Alaska Native Children Aged 7-11 Years. Helicobacter. 2006;11(3):159-67. PubMed PMID: 16684263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymptomatic Helicobacter pylori infection and iron deficiency are not associated with decreased growth among Alaska Native children aged 7-11 years. AU - Chimonas,Marc-Andre R, AU - Baggett,Henry C, AU - Parkinson,Alan J, AU - Muth,Pam T, AU - Dunaway,Eitel, AU - Gessner,Bradford D, PY - 2006/5/11/pubmed PY - 2006/7/13/medline PY - 2006/5/11/entrez SP - 159 EP - 67 JF - Helicobacter JO - Helicobacter VL - 11 IS - 3 N2 - INTRODUCTION: Alaska Native children have high Helicobacter pylori infection and iron deficiency prevalences, and their average height-for-age is lower than US reference populations. During a clinical trial to determine the impact of H. pylori treatment on iron deficiency, we evaluated the effects of H. pylori infection and treatment on growth. MATERIALS AND METHODS: We measured height and weight for children aged 7-11 years in western Alaska using village-based measuring devices. H. pylori infection was determined by urea breath test and iron deficiency using serum ferritin. Children with H. pylori infection and iron deficiency entered the treatment phase and received iron alone or iron plus triple therapy for H. pylori. Follow-up evaluations occurred at 2, 8, and 14 months. We evaluated the association between baseline H. pylori infection and growth; among children in the treatment phase, we also assessed the effect of H. pylori resolution on growth. RESULTS: At baseline, 566 (87.1%) of 650 children were infected with H. pylori. Neither height and weight, nor body mass index differed by H. pylori infection status. Of 189 children in the treatment phase, 20 (10.6%) were uninfected at all three follow-up periods, and 54 (28.6%) were uninfected for one or two periods. Compared with continuously infected children, children in these two groups had little evidence of improvements in any of the measured growth outcomes. CONCLUSIONS: H. pylori infection is not related to growth among Alaska Native children aged 7-11 years. Growth deficiency should not be considered an indication for H. pylori therapy. SN - 1083-4389 UR - https://www.unboundmedicine.com/medline/citation/16684263/Asymptomatic_Helicobacter_pylori_infection_and_iron_deficiency_are_not_associated_with_decreased_growth_among_Alaska_Native_children_aged_7_11_years_ L2 - https://doi.org/10.1111/j.1523-5378.2006.00395.x DB - PRIME DP - Unbound Medicine ER -