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The efficacy of excimer laser (308 nm) for vitiligo at different body sites.
J Eur Acad Dermatol Venereol. 2006 May; 20(5):558-64.JE

Abstract

BACKGROUND

The treatment with XeCl-excimer laser generated 308-nm UVB radiation has shown promising results in patients with vitiligo.

OBJECTIVE

In this controlled, prospective trial we studied the primary efficacy (start and grade of repigmentation) and patient's satisfaction of XeCl-excimer laser for treatment of vitiligo patches at different body sites and re-evaluated the achieved repigmentation 12 months after the end of therapy.

METHODS

Twenty-five patients with generalized or localized vitiligo with a total of 85 lesions at different body sites were enrolled in this study. Vitiligo patches were treated with 308-nm XeCl-excimer laser 3 times a week for 6 to 10 weeks. The overall repigmentation grade of each treated lesion was evaluated once a week on a 5 point scale rating from 0 (no repigmentation), 1 (1-5%), 2 (6-25%), 3 (26-50%), 4 (51-75%), to 5 (76-100%).

RESULTS

Twenty-four patients completed the study. Within 6 to 10 weeks of treatment 67% of the patients (16/24) developed follicular repigmentation of at least one of their vitiligo lesions. Lesion repigmentation started after a mean of 13 treatments in lesions located on the face, trunk, arm, and/or leg (high-responder location), and after a mean of 22 treatments in lesions located on the elbow, wrist, dorsum of the hand, knee, and/or dorsum of the foot (low-responder location). Untreated control lesions and lesions located on the fingers did not achieve any repigmentation. After 10 weeks of treatment repigmentation of more than 75% was found in 25% (7/28) of lesions of the high-responder location group versus 2% (1/43) of lesions of the low-responder location group. In most cases, laser-induced repigmentation was persistent, as determined 12 months after the end of treatment.

CONCLUSIONS

308-nm excimer laser is an effective modality for the treatment of vitiligo. However, similar to other non-surgical treatment modalities, the therapeutic effect is mainly dependent on the location of vitiligo lesions.

Authors+Show Affiliations

Medical University of Graz, Department of Dermatology, Graz, Austria. angelika.hofer@meduni-graz.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16684284

Citation

Hofer, A, et al. "The Efficacy of Excimer Laser (308 Nm) for Vitiligo at Different Body Sites." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 20, no. 5, 2006, pp. 558-64.
Hofer A, Hassan AS, Legat FJ, et al. The efficacy of excimer laser (308 nm) for vitiligo at different body sites. J Eur Acad Dermatol Venereol. 2006;20(5):558-64.
Hofer, A., Hassan, A. S., Legat, F. J., Kerl, H., & Wolf, P. (2006). The efficacy of excimer laser (308 nm) for vitiligo at different body sites. Journal of the European Academy of Dermatology and Venereology : JEADV, 20(5), 558-64.
Hofer A, et al. The Efficacy of Excimer Laser (308 Nm) for Vitiligo at Different Body Sites. J Eur Acad Dermatol Venereol. 2006;20(5):558-64. PubMed PMID: 16684284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy of excimer laser (308 nm) for vitiligo at different body sites. AU - Hofer,A, AU - Hassan,A S, AU - Legat,F J, AU - Kerl,H, AU - Wolf,P, PY - 2006/5/11/pubmed PY - 2006/10/27/medline PY - 2006/5/11/entrez SP - 558 EP - 64 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 20 IS - 5 N2 - BACKGROUND: The treatment with XeCl-excimer laser generated 308-nm UVB radiation has shown promising results in patients with vitiligo. OBJECTIVE: In this controlled, prospective trial we studied the primary efficacy (start and grade of repigmentation) and patient's satisfaction of XeCl-excimer laser for treatment of vitiligo patches at different body sites and re-evaluated the achieved repigmentation 12 months after the end of therapy. METHODS: Twenty-five patients with generalized or localized vitiligo with a total of 85 lesions at different body sites were enrolled in this study. Vitiligo patches were treated with 308-nm XeCl-excimer laser 3 times a week for 6 to 10 weeks. The overall repigmentation grade of each treated lesion was evaluated once a week on a 5 point scale rating from 0 (no repigmentation), 1 (1-5%), 2 (6-25%), 3 (26-50%), 4 (51-75%), to 5 (76-100%). RESULTS: Twenty-four patients completed the study. Within 6 to 10 weeks of treatment 67% of the patients (16/24) developed follicular repigmentation of at least one of their vitiligo lesions. Lesion repigmentation started after a mean of 13 treatments in lesions located on the face, trunk, arm, and/or leg (high-responder location), and after a mean of 22 treatments in lesions located on the elbow, wrist, dorsum of the hand, knee, and/or dorsum of the foot (low-responder location). Untreated control lesions and lesions located on the fingers did not achieve any repigmentation. After 10 weeks of treatment repigmentation of more than 75% was found in 25% (7/28) of lesions of the high-responder location group versus 2% (1/43) of lesions of the low-responder location group. In most cases, laser-induced repigmentation was persistent, as determined 12 months after the end of treatment. CONCLUSIONS: 308-nm excimer laser is an effective modality for the treatment of vitiligo. However, similar to other non-surgical treatment modalities, the therapeutic effect is mainly dependent on the location of vitiligo lesions. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/16684284/The_efficacy_of_excimer_laser__308_nm__for_vitiligo_at_different_body_sites_ L2 - https://doi.org/10.1111/j.1468-3083.2006.01547.x DB - PRIME DP - Unbound Medicine ER -