Tags

Type your tag names separated by a space and hit enter

Co-infection of human parvovirus B19 in Vietnamese patients with hepatitis B virus infection.
J Hepatol. 2006 Sep; 45(3):361-9.JH

Abstract

BACKGROUND/AIMS

Human parvovirus B19 (B19) has been identified in the serum of hepatitis B virus (HBV) infected patients. However, the effect of B19-infection on the course of HBV-associated liver disease has not previously been investigated. We examined the prevalence of B19-DNA in HBV-infected Vietnamese patients and analysed the association between co-infection and the clinical outcome of HBV-infection.

METHODS

Serum samples from 399 HBV-infected patients and 64 healthy individuals were analysed for the presence of B19-DNA by PCR and DNA-sequencing.

RESULTS

B19-DNA was detected in 99/463 (21.4%) individuals. The proportion of HBV-infected patients who were also co-infected with B19 was higher than the healthy controls (P<0.001). B19-DNA was detected more frequently in patients with HBV-associated hepatocellular carcinoma compared to patients with acute and chronic HBV, HBV-associated liver cirrhosis and healthy subjects (P<0.006). A positive correlation was also found between B19-DNA loads and both serum HBV-DNA loads and alanine aminotransferase (rho>0.250 and P<0.05).

CONCLUSIONS

Our findings demonstrate that B19-infection is frequent in HBV-infected Vietnamese patients. Also, a significant correlation exists between HBV/B19 co-infection and a greater likelihood of progression to more severe hepatitis B-associated liver disease. Further studies are required to determine the role of B19-infection on HBV-associated pathogenesis.

Authors+Show Affiliations

Department of Molecular Pathology, Institute of Pathology, University Hospital of Tuebingen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16684578

Citation

Toan, Nguyen L., et al. "Co-infection of Human Parvovirus B19 in Vietnamese Patients With Hepatitis B Virus Infection." Journal of Hepatology, vol. 45, no. 3, 2006, pp. 361-9.
Toan NL, Song le H, Kremsner PG, et al. Co-infection of human parvovirus B19 in Vietnamese patients with hepatitis B virus infection. J Hepatol. 2006;45(3):361-9.
Toan, N. L., Song, l. e. . H., Kremsner, P. G., Duy, D. N., Binh, V. Q., Duechting, A., Kaiser, H., Torresi, J., Kandolf, R., & Bock, C. T. (2006). Co-infection of human parvovirus B19 in Vietnamese patients with hepatitis B virus infection. Journal of Hepatology, 45(3), 361-9.
Toan NL, et al. Co-infection of Human Parvovirus B19 in Vietnamese Patients With Hepatitis B Virus Infection. J Hepatol. 2006;45(3):361-9. PubMed PMID: 16684578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-infection of human parvovirus B19 in Vietnamese patients with hepatitis B virus infection. AU - Toan,Nguyen L, AU - Song,Le H, AU - Kremsner,Peter G, AU - Duy,Dinh N, AU - Binh,Vu Q, AU - Duechting,Anja, AU - Kaiser,Heike, AU - Torresi,Joseph, AU - Kandolf,Reinhard, AU - Bock,C-Thomas, Y1 - 2006/04/27/ PY - 2005/12/15/received PY - 2006/02/27/revised PY - 2006/03/12/accepted PY - 2006/5/11/pubmed PY - 2006/12/29/medline PY - 2006/5/11/entrez SP - 361 EP - 9 JF - Journal of hepatology JO - J Hepatol VL - 45 IS - 3 N2 - BACKGROUND/AIMS: Human parvovirus B19 (B19) has been identified in the serum of hepatitis B virus (HBV) infected patients. However, the effect of B19-infection on the course of HBV-associated liver disease has not previously been investigated. We examined the prevalence of B19-DNA in HBV-infected Vietnamese patients and analysed the association between co-infection and the clinical outcome of HBV-infection. METHODS: Serum samples from 399 HBV-infected patients and 64 healthy individuals were analysed for the presence of B19-DNA by PCR and DNA-sequencing. RESULTS: B19-DNA was detected in 99/463 (21.4%) individuals. The proportion of HBV-infected patients who were also co-infected with B19 was higher than the healthy controls (P<0.001). B19-DNA was detected more frequently in patients with HBV-associated hepatocellular carcinoma compared to patients with acute and chronic HBV, HBV-associated liver cirrhosis and healthy subjects (P<0.006). A positive correlation was also found between B19-DNA loads and both serum HBV-DNA loads and alanine aminotransferase (rho>0.250 and P<0.05). CONCLUSIONS: Our findings demonstrate that B19-infection is frequent in HBV-infected Vietnamese patients. Also, a significant correlation exists between HBV/B19 co-infection and a greater likelihood of progression to more severe hepatitis B-associated liver disease. Further studies are required to determine the role of B19-infection on HBV-associated pathogenesis. SN - 0168-8278 UR - https://www.unboundmedicine.com/medline/citation/16684578/Co_infection_of_human_parvovirus_B19_in_Vietnamese_patients_with_hepatitis_B_virus_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(06)00218-2 DB - PRIME DP - Unbound Medicine ER -