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Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study.
J Hepatol. 2006 Aug; 45(2):197-203.JH

Abstract

BACKGROUND/AIMS

Risks of hepatocellular carcinoma (HCC) following hepatitis B and/or hepatitis C virus (HBV/HCV) infection are well known, those for other cancers are less well understood. The aim was to quantify the risk of cancers among persons diagnosed with HBV/HCV infections.

METHODS

The data from a cohort of 39109 HBV, 75834 HCV, and 2604 HBV/HCV co-infected persons notified to the State health department, 1990-2002, were probabilistically linked to the Cancer Registry and standardised incidence ratios (SIRs) for cancer were calculated.

RESULTS

The match rate for any cancer was 2.7%, 2.3% and 3.3% for HBV, HCV and HBV/HCV co-infected notifications. SIRs for HCC were 30.6 (95% CI 25.7-36.5), 22.7 (95% CI 19.1-26.5) and 30.3 (95% CI 13.6-67.5), respectively. Increased risk was detected for Burkitt's lymphoma and HBV (SIR 12.9, 95% CI 5.4-30.9) and immunoproliferative malignancies following HCV (SIR 5.6, 95% CI 1.8-17.5).

CONCLUSIONS

The risk of HCC in the infected cohort was 20-30 times greater than in the uninfected population with SIRs two to three times greater than those for the other HBV/HCV infection associated cancers. The modest though significant risk of immunoproliferative malignancies associated with HCV infection is consistent with recent findings.

Authors+Show Affiliations

National Centre in HIV Epidemiology and Clinical Research, Sydney, Australia. jamin@nchecr.unsw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16684579

Citation

Amin, Janaki, et al. "Cancer Incidence in People With Hepatitis B or C Infection: a Large Community-based Linkage Study." Journal of Hepatology, vol. 45, no. 2, 2006, pp. 197-203.
Amin J, Dore GJ, O'Connell DL, et al. Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study. J Hepatol. 2006;45(2):197-203.
Amin, J., Dore, G. J., O'Connell, D. L., Bartlett, M., Tracey, E., Kaldor, J. M., & Law, M. G. (2006). Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study. Journal of Hepatology, 45(2), 197-203.
Amin J, et al. Cancer Incidence in People With Hepatitis B or C Infection: a Large Community-based Linkage Study. J Hepatol. 2006;45(2):197-203. PubMed PMID: 16684579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study. AU - Amin,Janaki, AU - Dore,Gregory J, AU - O'Connell,Dianne L, AU - Bartlett,Mark, AU - Tracey,Elizabeth, AU - Kaldor,John M, AU - Law,Matthew G, Y1 - 2006/03/31/ PY - 2005/10/10/received PY - 2006/02/07/revised PY - 2006/02/27/accepted PY - 2006/5/11/pubmed PY - 2006/12/9/medline PY - 2006/5/11/entrez SP - 197 EP - 203 JF - Journal of hepatology JO - J Hepatol VL - 45 IS - 2 N2 - BACKGROUND/AIMS: Risks of hepatocellular carcinoma (HCC) following hepatitis B and/or hepatitis C virus (HBV/HCV) infection are well known, those for other cancers are less well understood. The aim was to quantify the risk of cancers among persons diagnosed with HBV/HCV infections. METHODS: The data from a cohort of 39109 HBV, 75834 HCV, and 2604 HBV/HCV co-infected persons notified to the State health department, 1990-2002, were probabilistically linked to the Cancer Registry and standardised incidence ratios (SIRs) for cancer were calculated. RESULTS: The match rate for any cancer was 2.7%, 2.3% and 3.3% for HBV, HCV and HBV/HCV co-infected notifications. SIRs for HCC were 30.6 (95% CI 25.7-36.5), 22.7 (95% CI 19.1-26.5) and 30.3 (95% CI 13.6-67.5), respectively. Increased risk was detected for Burkitt's lymphoma and HBV (SIR 12.9, 95% CI 5.4-30.9) and immunoproliferative malignancies following HCV (SIR 5.6, 95% CI 1.8-17.5). CONCLUSIONS: The risk of HCC in the infected cohort was 20-30 times greater than in the uninfected population with SIRs two to three times greater than those for the other HBV/HCV infection associated cancers. The modest though significant risk of immunoproliferative malignancies associated with HCV infection is consistent with recent findings. SN - 0168-8278 UR - https://www.unboundmedicine.com/medline/citation/16684579/Cancer_incidence_in_people_with_hepatitis_B_or_C_infection:_a_large_community_based_linkage_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(06)00167-X DB - PRIME DP - Unbound Medicine ER -