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Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson's disease.
Brain. 2006 Jul; 129(Pt 7):1748-57.B

Abstract

The pathophysiology of levodopa-induced dyskinesias (LID) in Parkinson's disease is not well understood. We have recorded local field potentials (LFP) from macroelectrodes implanted in the subthalamic nucleus (STN) of 14 patients with Parkinson's disease following surgical treatment with deep brain stimulation. Patients were studied in the 'Off' medication state and in the 'On' motor state after administration of levodopa-carbidopa (po) or apomorphine (sc) that elicited dyskinesias in 11 patients. The logarithm of the power spectrum of the LFP in selected frequency bands (4-10, 11-30 and 60-80 Hz) was compared between the 'Off' and 'On' medication states. A peak in the 11-30 Hz band was recorded in the 'Off' medication state and reduced by 45.2% (P < 0.001) in the 'On' state. The 'On' was also associated with an increment of 77. 6% (P < 0.001) in the 4-10 Hz band in all patients who showed dyskinesias and of 17.8% (P < 0.001) in the 60-80 Hz band in the majority of patients. When dyskinesias were only present in one limb (n = 2), the 4-10 Hz peak was only recorded in the contralateral STN. These findings suggest that the 4-10 Hz oscillation is associated with the expression of LID in Parkinson's disease.

Authors+Show Affiliations

Department of Neurology and Neurosurgery, Neuroscience Area, Clinica Universitaria and Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra Pamplona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16684788

Citation

Alonso-Frech, F, et al. "Slow Oscillatory Activity and Levodopa-induced Dyskinesias in Parkinson's Disease." Brain : a Journal of Neurology, vol. 129, no. Pt 7, 2006, pp. 1748-57.
Alonso-Frech F, Zamarbide I, Alegre M, et al. Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson's disease. Brain. 2006;129(Pt 7):1748-57.
Alonso-Frech, F., Zamarbide, I., Alegre, M., Rodríguez-Oroz, M. C., Guridi, J., Manrique, M., Valencia, M., Artieda, J., & Obeso, J. A. (2006). Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson's disease. Brain : a Journal of Neurology, 129(Pt 7), 1748-57.
Alonso-Frech F, et al. Slow Oscillatory Activity and Levodopa-induced Dyskinesias in Parkinson's Disease. Brain. 2006;129(Pt 7):1748-57. PubMed PMID: 16684788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson's disease. AU - Alonso-Frech,F, AU - Zamarbide,I, AU - Alegre,M, AU - Rodríguez-Oroz,M C, AU - Guridi,J, AU - Manrique,M, AU - Valencia,M, AU - Artieda,J, AU - Obeso,J A, Y1 - 2006/05/09/ PY - 2006/5/11/pubmed PY - 2006/8/4/medline PY - 2006/5/11/entrez SP - 1748 EP - 57 JF - Brain : a journal of neurology JO - Brain VL - 129 IS - Pt 7 N2 - The pathophysiology of levodopa-induced dyskinesias (LID) in Parkinson's disease is not well understood. We have recorded local field potentials (LFP) from macroelectrodes implanted in the subthalamic nucleus (STN) of 14 patients with Parkinson's disease following surgical treatment with deep brain stimulation. Patients were studied in the 'Off' medication state and in the 'On' motor state after administration of levodopa-carbidopa (po) or apomorphine (sc) that elicited dyskinesias in 11 patients. The logarithm of the power spectrum of the LFP in selected frequency bands (4-10, 11-30 and 60-80 Hz) was compared between the 'Off' and 'On' medication states. A peak in the 11-30 Hz band was recorded in the 'Off' medication state and reduced by 45.2% (P < 0.001) in the 'On' state. The 'On' was also associated with an increment of 77. 6% (P < 0.001) in the 4-10 Hz band in all patients who showed dyskinesias and of 17.8% (P < 0.001) in the 60-80 Hz band in the majority of patients. When dyskinesias were only present in one limb (n = 2), the 4-10 Hz peak was only recorded in the contralateral STN. These findings suggest that the 4-10 Hz oscillation is associated with the expression of LID in Parkinson's disease. SN - 1460-2156 UR - https://www.unboundmedicine.com/medline/citation/16684788/Slow_oscillatory_activity_and_levodopa_induced_dyskinesias_in_Parkinson's_disease_ L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awl103 DB - PRIME DP - Unbound Medicine ER -