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The role of vitamin D in multiple sclerosis.
Ann Pharmacother 2006; 40(6):1158-61AP

Abstract

OBJECTIVE

To evaluate the literature about the role of vitamin D in the prevention and treatment of multiple sclerosis (MS).

DATA SOURCES

MEDLINE (1966-April 2006) and International Pharmaceutical Abstracts (1970-April 2006) searches were performed. In addition, pertinent references from identified articles were obtained. Key search terms included vitamin D, 25-hydroxyvitamin D, vitamin D deficiency, and multiple sclerosis.

DATA SYNTHESIS

Vitamin D supplementation prevented the development and progression of experimental autoimmune encephalitis, an animal model of MS, in mice. A large, prospective, cohort study found that vitamin D supplementation was associated with a 40% reduction in the risk of developing MS. Four small, noncontrolled studies suggested that vitamin D supplementation may decrease exacerbation of MS symptoms.

CONCLUSIONS

Vitamin D supplementation may help prevent the development of MS and may be a useful addition to therapy. However, current studies are in small populations and are confounded by other variables, such as additional vitamin and mineral supplementation.

Authors+Show Affiliations

Drug Information Service, Skaggs School of Pharmacy, College of Health Professions and Biomedical Sciences, The University of Montana, Missoula, 59812-1522, USA. sherrill.brown@umontana.edux

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16684809

Citation

Brown, Sherrill J.. "The Role of Vitamin D in Multiple Sclerosis." The Annals of Pharmacotherapy, vol. 40, no. 6, 2006, pp. 1158-61.
Brown SJ. The role of vitamin D in multiple sclerosis. Ann Pharmacother. 2006;40(6):1158-61.
Brown, S. J. (2006). The role of vitamin D in multiple sclerosis. The Annals of Pharmacotherapy, 40(6), pp. 1158-61.
Brown SJ. The Role of Vitamin D in Multiple Sclerosis. Ann Pharmacother. 2006;40(6):1158-61. PubMed PMID: 16684809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of vitamin D in multiple sclerosis. A1 - Brown,Sherrill J, Y1 - 2006/05/09/ PY - 2006/5/11/pubmed PY - 2006/8/24/medline PY - 2006/5/11/entrez SP - 1158 EP - 61 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 40 IS - 6 N2 - OBJECTIVE: To evaluate the literature about the role of vitamin D in the prevention and treatment of multiple sclerosis (MS). DATA SOURCES: MEDLINE (1966-April 2006) and International Pharmaceutical Abstracts (1970-April 2006) searches were performed. In addition, pertinent references from identified articles were obtained. Key search terms included vitamin D, 25-hydroxyvitamin D, vitamin D deficiency, and multiple sclerosis. DATA SYNTHESIS: Vitamin D supplementation prevented the development and progression of experimental autoimmune encephalitis, an animal model of MS, in mice. A large, prospective, cohort study found that vitamin D supplementation was associated with a 40% reduction in the risk of developing MS. Four small, noncontrolled studies suggested that vitamin D supplementation may decrease exacerbation of MS symptoms. CONCLUSIONS: Vitamin D supplementation may help prevent the development of MS and may be a useful addition to therapy. However, current studies are in small populations and are confounded by other variables, such as additional vitamin and mineral supplementation. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/16684809/The_role_of_vitamin_D_in_multiple_sclerosis_ L2 - http://journals.sagepub.com/doi/full/10.1345/aph.1G513?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -