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Role of risperidone in children with autism spectrum disorder.
Ann Pharmacother. 2006 May; 40(5):909-16.AP

Abstract

OBJECTIVE

To review the clinical trials investigating the efficacy and safety of risperidone in the treatment of children with autism spectrum disorder (ASD).

DATA SOURCES

Searches of MEDLINE/PubMed (1992-February 2006) were conducted, as well as an extensive manual review of journals, using the key words autism and risperidone.

STUDY SELECTION AND DATA EXTRACTION

Only double-blind, placebo-controlled trials were included for review.

DATA SYNTHESIS

ASD is the most common of the pervasive developmental disorders. The main characteristics (core symptoms) of autism are impairment in social skills, problems communicating, and stereotypical movements. Behavioral manifestations or maladaptive behaviors include aggression, irritability, hyperactivity, inattention, impulsivity, tantrums, and self-injurious behavior.

CONCLUSIONS

Based on the data examined, risperidone appears efficacious and safe for treating certain behavioral aspects of autism including irritability, aggression, hyperactivity, and stereotypy. It does not appear to be as effective for the treatment of the core symptoms of autism.

Authors+Show Affiliations

Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA. bchavez@rci.rutgers.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16684811

Citation

Chavez, Benjamin, et al. "Role of Risperidone in Children With Autism Spectrum Disorder." The Annals of Pharmacotherapy, vol. 40, no. 5, 2006, pp. 909-16.
Chavez B, Chavez-Brown M, Rey JA. Role of risperidone in children with autism spectrum disorder. Ann Pharmacother. 2006;40(5):909-16.
Chavez, B., Chavez-Brown, M., & Rey, J. A. (2006). Role of risperidone in children with autism spectrum disorder. The Annals of Pharmacotherapy, 40(5), 909-16.
Chavez B, Chavez-Brown M, Rey JA. Role of Risperidone in Children With Autism Spectrum Disorder. Ann Pharmacother. 2006;40(5):909-16. PubMed PMID: 16684811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of risperidone in children with autism spectrum disorder. AU - Chavez,Benjamin, AU - Chavez-Brown,Mapy, AU - Rey,Jose A, Y1 - 2006/03/07/ PY - 2006/5/11/pubmed PY - 2006/8/1/medline PY - 2006/5/11/entrez SP - 909 EP - 16 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 40 IS - 5 N2 - OBJECTIVE: To review the clinical trials investigating the efficacy and safety of risperidone in the treatment of children with autism spectrum disorder (ASD). DATA SOURCES: Searches of MEDLINE/PubMed (1992-February 2006) were conducted, as well as an extensive manual review of journals, using the key words autism and risperidone. STUDY SELECTION AND DATA EXTRACTION: Only double-blind, placebo-controlled trials were included for review. DATA SYNTHESIS: ASD is the most common of the pervasive developmental disorders. The main characteristics (core symptoms) of autism are impairment in social skills, problems communicating, and stereotypical movements. Behavioral manifestations or maladaptive behaviors include aggression, irritability, hyperactivity, inattention, impulsivity, tantrums, and self-injurious behavior. CONCLUSIONS: Based on the data examined, risperidone appears efficacious and safe for treating certain behavioral aspects of autism including irritability, aggression, hyperactivity, and stereotypy. It does not appear to be as effective for the treatment of the core symptoms of autism. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/16684811/Role_of_risperidone_in_children_with_autism_spectrum_disorder_ L2 - http://journals.sagepub.com/doi/full/10.1345/aph.1G389?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -