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Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats.
Am J Physiol Endocrinol Metab 2006; 291(3):E675-82AJ

Abstract

An increased rate of fatty acid transport into skeletal muscle has been has been linked to the accumulation of intramuscular lipids and insulin resistance, and red muscles are more susceptible than white muscles in developing fatty acid-mediated insulin resistance. Therefore, we examined in Zucker diabetic fatty (ZDF) rats, relative to lean rats, 1) whether rates of fatty acid transport and transporters (FAT/CD36 and FABPpm) were upregulated in skeletal muscle during the transition from insulin resistance (week 6) to type 2 diabetes (weeks 12 and 24), 2) whether such changes occurred primarily in red skeletal muscle, and 3) whether changes in FAT/CD36 and GLUT4 were correlated. In red muscles of ZDF compared with lean rats, the rates of fatty acid transport were upregulated (+66%) early in life (week 6). Compared with the increase in fatty acid transport in lean red muscle from weeks 12-24 (+57%), the increase in fatty acid transport rate in ZDF red muscle was 50% greater during this same period. In contrast, no differences in fatty acid transport rates were observed in the white muscles of lean and ZDF rats at any time (weeks 6-24). In red muscle only, there was an inverse relationship between FAT/CD36 and GLUT4 protein expression as well as their plasmalemmal content. These studies have shown that, 1) before the onset of diabetes, as well as during diabetes, fatty acid transport and FAT/CD36 expression and plasmalemmal content are upregulated in ZDF rats, but importantly, 2) these changes occurred only in red, not white, muscles of ZDF rats.

Authors+Show Affiliations

Dept. of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16684853

Citation

Chabowski, Adrian, et al. "Fatty Acid Transport and FAT/CD36 Are Increased in Red but Not in White Skeletal Muscle of ZDF Rats." American Journal of Physiology. Endocrinology and Metabolism, vol. 291, no. 3, 2006, pp. E675-82.
Chabowski A, Chatham JC, Tandon NN, et al. Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats. Am J Physiol Endocrinol Metab. 2006;291(3):E675-82.
Chabowski, A., Chatham, J. C., Tandon, N. N., Calles-Escandon, J., Glatz, J. F., Luiken, J. J., & Bonen, A. (2006). Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats. American Journal of Physiology. Endocrinology and Metabolism, 291(3), pp. E675-82.
Chabowski A, et al. Fatty Acid Transport and FAT/CD36 Are Increased in Red but Not in White Skeletal Muscle of ZDF Rats. Am J Physiol Endocrinol Metab. 2006;291(3):E675-82. PubMed PMID: 16684853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats. AU - Chabowski,Adrian, AU - Chatham,John C, AU - Tandon,Narendra N, AU - Calles-Escandon,Jorge, AU - Glatz,Jan F C, AU - Luiken,Joost J F P, AU - Bonen,Arend, Y1 - 2006/05/09/ PY - 2006/5/11/pubmed PY - 2006/9/27/medline PY - 2006/5/11/entrez SP - E675 EP - 82 JF - American journal of physiology. Endocrinology and metabolism JO - Am. J. Physiol. Endocrinol. Metab. VL - 291 IS - 3 N2 - An increased rate of fatty acid transport into skeletal muscle has been has been linked to the accumulation of intramuscular lipids and insulin resistance, and red muscles are more susceptible than white muscles in developing fatty acid-mediated insulin resistance. Therefore, we examined in Zucker diabetic fatty (ZDF) rats, relative to lean rats, 1) whether rates of fatty acid transport and transporters (FAT/CD36 and FABPpm) were upregulated in skeletal muscle during the transition from insulin resistance (week 6) to type 2 diabetes (weeks 12 and 24), 2) whether such changes occurred primarily in red skeletal muscle, and 3) whether changes in FAT/CD36 and GLUT4 were correlated. In red muscles of ZDF compared with lean rats, the rates of fatty acid transport were upregulated (+66%) early in life (week 6). Compared with the increase in fatty acid transport in lean red muscle from weeks 12-24 (+57%), the increase in fatty acid transport rate in ZDF red muscle was 50% greater during this same period. In contrast, no differences in fatty acid transport rates were observed in the white muscles of lean and ZDF rats at any time (weeks 6-24). In red muscle only, there was an inverse relationship between FAT/CD36 and GLUT4 protein expression as well as their plasmalemmal content. These studies have shown that, 1) before the onset of diabetes, as well as during diabetes, fatty acid transport and FAT/CD36 expression and plasmalemmal content are upregulated in ZDF rats, but importantly, 2) these changes occurred only in red, not white, muscles of ZDF rats. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/16684853/Fatty_acid_transport_and_FAT/CD36_are_increased_in_red_but_not_in_white_skeletal_muscle_of_ZDF_rats_ L2 - http://www.physiology.org/doi/full/10.1152/ajpendo.00096.2006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -