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Withdrawal of red meat from the usual diet reduces albuminuria and improves serum fatty acid profile in type 2 diabetes patients with macroalbuminuria.
Am J Clin Nutr. 2006 May; 83(5):1032-8.AJ

Abstract

BACKGROUND

Replacement of red meat in the diet with chicken has reduced the urinary albumin excretion rate (UAER) and serum cholesterol in microalbuminuric type 2 diabetes patients. The effects of withdrawing red meat are unknown in the more advanced stages of diabetic nephropathy.

OBJECTIVE

Our objective was to assess the effects of replacing red meat in the usual diet (UD) with chicken (CD) and of consuming a lactovegetarian low-protein diet (LPD) on renal function, fatty acid, and lipid profile in macroalbuminuric type 2 diabetes patients.

DESIGN

A crossover controlled trial was conducted in 17 type 2 diabetes patients with macroalbuminuria (24-h UAER > or = 200 microg/min). Each patient followed the UD, CD, and LPD in a random order for 4 wk. After each diet, glomerular filtration rate, UAER, serum fatty acid, lipid profile, glycemic control, anthropometric indexes, and blood pressure were measured.

RESULTS

UAER [median CD: 269.4 (range: 111-1128) microg/min; LPD: 229.3 (76.6-999.3) microg/min; UD: 312.8 (223.7-1223.7) microg/min; P < 0.01] and mean (+/-SD) non-HDL cholesterol (CD: 3.92 +/- 0.99 mmol/L; LPD: 3.92 +/- 0.93 mmol/L; UD: 4.23 +/- 1.06 mmol/L; P = 0.042) were lower after CD and LPD than after UD. Compared with the UD, an increase in serum total polyunsaturated fatty acids was also observed (CD: 39.8 +/- 2.6%; LPD: 39.7 +/- 4.4%; UD: 37.3 +/- 3.1%; P = 0.029).

CONCLUSION

In macroalbuminuric patients with type 2 diabetes, withdrawing red meat from the diet reduces the UAER.

Authors+Show Affiliations

de Mello VD
Endocrinology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Zelmanovitz T
No affiliation info available
Perassolo MS
No affiliation info available
Azevedo MJ
No affiliation info available
Gross JL
No affiliation info available

MeSH

AgedAlbuminuriaAnimalsAnthropometryBlood GlucoseBlood PressureBody Mass IndexChickensCross-Over StudiesDiabetes Mellitus, Type 2DietDiet, Protein-RestrictedDiet, VegetarianFatty AcidsHumansKidneyLipidsMeatMiddle Aged

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16685043

Clinical Trial Links

Chicken-Diet vs. Enalapril to Reduce Albuminuria

Citation

de Mello, Vanessa D F., et al. "Withdrawal of Red Meat From the Usual Diet Reduces Albuminuria and Improves Serum Fatty Acid Profile in Type 2 Diabetes Patients With Macroalbuminuria." The American Journal of Clinical Nutrition, vol. 83, no. 5, 2006, pp. 1032-8.
de Mello VD, Zelmanovitz T, Perassolo MS, et al. Withdrawal of red meat from the usual diet reduces albuminuria and improves serum fatty acid profile in type 2 diabetes patients with macroalbuminuria. Am J Clin Nutr. 2006;83(5):1032-8.
de Mello, V. D., Zelmanovitz, T., Perassolo, M. S., Azevedo, M. J., & Gross, J. L. (2006). Withdrawal of red meat from the usual diet reduces albuminuria and improves serum fatty acid profile in type 2 diabetes patients with macroalbuminuria. The American Journal of Clinical Nutrition, 83(5), 1032-8.
de Mello VD, et al. Withdrawal of Red Meat From the Usual Diet Reduces Albuminuria and Improves Serum Fatty Acid Profile in Type 2 Diabetes Patients With Macroalbuminuria. Am J Clin Nutr. 2006;83(5):1032-8. PubMed PMID: 16685043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Withdrawal of red meat from the usual diet reduces albuminuria and improves serum fatty acid profile in type 2 diabetes patients with macroalbuminuria. AU - de Mello,Vanessa D F, AU - Zelmanovitz,Themis, AU - Perassolo,Magda S, AU - Azevedo,Mirela J, AU - Gross,Jorge L, PY - 2006/5/11/pubmed PY - 2006/6/21/medline PY - 2006/5/11/entrez SP - 1032 EP - 8 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 83 IS - 5 N2 - BACKGROUND: Replacement of red meat in the diet with chicken has reduced the urinary albumin excretion rate (UAER) and serum cholesterol in microalbuminuric type 2 diabetes patients. The effects of withdrawing red meat are unknown in the more advanced stages of diabetic nephropathy. OBJECTIVE: Our objective was to assess the effects of replacing red meat in the usual diet (UD) with chicken (CD) and of consuming a lactovegetarian low-protein diet (LPD) on renal function, fatty acid, and lipid profile in macroalbuminuric type 2 diabetes patients. DESIGN: A crossover controlled trial was conducted in 17 type 2 diabetes patients with macroalbuminuria (24-h UAER > or = 200 microg/min). Each patient followed the UD, CD, and LPD in a random order for 4 wk. After each diet, glomerular filtration rate, UAER, serum fatty acid, lipid profile, glycemic control, anthropometric indexes, and blood pressure were measured. RESULTS: UAER [median CD: 269.4 (range: 111-1128) microg/min; LPD: 229.3 (76.6-999.3) microg/min; UD: 312.8 (223.7-1223.7) microg/min; P < 0.01] and mean (+/-SD) non-HDL cholesterol (CD: 3.92 +/- 0.99 mmol/L; LPD: 3.92 +/- 0.93 mmol/L; UD: 4.23 +/- 1.06 mmol/L; P = 0.042) were lower after CD and LPD than after UD. Compared with the UD, an increase in serum total polyunsaturated fatty acids was also observed (CD: 39.8 +/- 2.6%; LPD: 39.7 +/- 4.4%; UD: 37.3 +/- 3.1%; P = 0.029). CONCLUSION: In macroalbuminuric patients with type 2 diabetes, withdrawing red meat from the diet reduces the UAER. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/16685043/Withdrawal_of_red_meat_from_the_usual_diet_reduces_albuminuria_and_improves_serum_fatty_acid_profile_in_type_2_diabetes_patients_with_macroalbuminuria_ DB - PRIME DP - Unbound Medicine ER -