Tags

Type your tag names separated by a space and hit enter

Tumour volume is an independent predictor of prostate-specific antigen recurrence in patients undergoing radical prostatectomy for clinically localized prostate cancer.
BJU Int. 2006 Jun; 97(6):1169-72.BI

Abstract

Authors from the USA sought to establish the relationship between tumour volume, pathological stage and outcomes after radical prostatectomy. In a large series of patients they found that tumour volume was correlated directly with pathological stage, and that it was independently correlated with PSA recurrence. The authors suggested that tumour volume had a potential use for prognostication in patients undergoing radical prostatectomy. Two papers, one from the USA and one from Germany, advise a re-staging TUR in patients with superficial bladder cancer who are at high risk of early tumour progression. In a large series of patients they found that residual tumour after initial resection was commoner than might be expected, and that the second resection indicated the way to earlier radical treatment and a better prognosis.

OBJECTIVE

To establish the relationship between tumour volume (TV), pathological stage and outcome after radical prostatectomy (RP), as TV is theoretically an important variable in prostate cancer pathology, but to date it has not been routinely reported and its independent prognostic significance is not well defined.

PATIENTS AND METHODS

The study included 431 consecutive patients undergoing RP for clinically localized cancer, from January 2000 to January 2002, who had a pathological examination of totally submitted whole-mount processed RP specimens. In addition to Gleason grade, tumour stage and margin assessment by standard techniques, TV was determined by digital planimetry. The total TV or index TV, for cases with obvious discrete separate tumours, were correlated with pathological stage and prostate-specific antigen (PSA) recurrence.

RESULTS

The mean (range) follow-up was 25.4 (6-51) months, and the mean TV for all patients was 3.28 (0.4-38.8) mL. There was a direct correlation between TV and pathological stage (P < 0.001). The TV for organ-confined and extraprostatic disease was 2.09 and 6.02 mL, respectively (P < 0.001). In a multivariate analysis, TV was an independent predictor of PSA recurrence (P = 0.04). The mean TV for patients with PSA recurrence vs no recurrence was 6.8 and 2.6 mL, respectively (P < 0.001).

CONCLUSION

TV correlates directly with pathological stage in RP specimens; furthermore, it is independently correlated with PSA recurrence. TV has potential use for prognostication in patients undergoing RP, and may be combined with other well established clinical variables to aid in predicting outcomes.

Authors+Show Affiliations

Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232-2765, USA. Bradford.nelson@vanderbilt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16686706

Citation

Nelson, Bradford A., et al. "Tumour Volume Is an Independent Predictor of Prostate-specific Antigen Recurrence in Patients Undergoing Radical Prostatectomy for Clinically Localized Prostate Cancer." BJU International, vol. 97, no. 6, 2006, pp. 1169-72.
Nelson BA, Shappell SB, Chang SS, et al. Tumour volume is an independent predictor of prostate-specific antigen recurrence in patients undergoing radical prostatectomy for clinically localized prostate cancer. BJU Int. 2006;97(6):1169-72.
Nelson, B. A., Shappell, S. B., Chang, S. S., Wells, N., Farnham, S. B., Smith, J. A., & Cookson, M. S. (2006). Tumour volume is an independent predictor of prostate-specific antigen recurrence in patients undergoing radical prostatectomy for clinically localized prostate cancer. BJU International, 97(6), 1169-72.
Nelson BA, et al. Tumour Volume Is an Independent Predictor of Prostate-specific Antigen Recurrence in Patients Undergoing Radical Prostatectomy for Clinically Localized Prostate Cancer. BJU Int. 2006;97(6):1169-72. PubMed PMID: 16686706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tumour volume is an independent predictor of prostate-specific antigen recurrence in patients undergoing radical prostatectomy for clinically localized prostate cancer. AU - Nelson,Bradford A, AU - Shappell,Scott B, AU - Chang,Sam S, AU - Wells,Nancy, AU - Farnham,Scott B, AU - Smith,Joseph A,Jr AU - Cookson,Michael S, PY - 2006/5/12/pubmed PY - 2006/6/29/medline PY - 2006/5/12/entrez SP - 1169 EP - 72 JF - BJU international JO - BJU Int VL - 97 IS - 6 N2 - UNLABELLED: Authors from the USA sought to establish the relationship between tumour volume, pathological stage and outcomes after radical prostatectomy. In a large series of patients they found that tumour volume was correlated directly with pathological stage, and that it was independently correlated with PSA recurrence. The authors suggested that tumour volume had a potential use for prognostication in patients undergoing radical prostatectomy. Two papers, one from the USA and one from Germany, advise a re-staging TUR in patients with superficial bladder cancer who are at high risk of early tumour progression. In a large series of patients they found that residual tumour after initial resection was commoner than might be expected, and that the second resection indicated the way to earlier radical treatment and a better prognosis. OBJECTIVE: To establish the relationship between tumour volume (TV), pathological stage and outcome after radical prostatectomy (RP), as TV is theoretically an important variable in prostate cancer pathology, but to date it has not been routinely reported and its independent prognostic significance is not well defined. PATIENTS AND METHODS: The study included 431 consecutive patients undergoing RP for clinically localized cancer, from January 2000 to January 2002, who had a pathological examination of totally submitted whole-mount processed RP specimens. In addition to Gleason grade, tumour stage and margin assessment by standard techniques, TV was determined by digital planimetry. The total TV or index TV, for cases with obvious discrete separate tumours, were correlated with pathological stage and prostate-specific antigen (PSA) recurrence. RESULTS: The mean (range) follow-up was 25.4 (6-51) months, and the mean TV for all patients was 3.28 (0.4-38.8) mL. There was a direct correlation between TV and pathological stage (P < 0.001). The TV for organ-confined and extraprostatic disease was 2.09 and 6.02 mL, respectively (P < 0.001). In a multivariate analysis, TV was an independent predictor of PSA recurrence (P = 0.04). The mean TV for patients with PSA recurrence vs no recurrence was 6.8 and 2.6 mL, respectively (P < 0.001). CONCLUSION: TV correlates directly with pathological stage in RP specimens; furthermore, it is independently correlated with PSA recurrence. TV has potential use for prognostication in patients undergoing RP, and may be combined with other well established clinical variables to aid in predicting outcomes. SN - 1464-4096 UR - https://www.unboundmedicine.com/medline/citation/16686706/Tumour_volume_is_an_independent_predictor_of_prostate_specific_antigen_recurrence_in_patients_undergoing_radical_prostatectomy_for_clinically_localized_prostate_cancer_ L2 - https://doi.org/10.1111/j.1464-410X.2006.06148.x DB - PRIME DP - Unbound Medicine ER -