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The beneficial effect of alfuzosin 10 mg once daily in 'real-life' practice on lower urinary tract symptoms (LUTS), quality of life and sexual dysfunction in men with LUTS and painful ejaculation.
BJU Int. 2006 Jun; 97(6):1242-6.BI

Abstract

OBJECTIVE

To determine the efficacy and safety of the selective alpha(1)-blocker alfuzosin in men with lower urinary tract symptoms (LUTS) and painful ejaculation, compared with those with LUTS only, as painful ejaculation is one of the most prevalent, differentiating and bothersome symptoms in men with chronic prostatitis/chronic pelvic pain syndrome.

PATIENTS AND METHODS

In all, 4857 sexually active men with LUTS had an evaluable answer to the Danish Prostate Symptom Score for Sexual Symptoms question related to pain/discomfort on ejaculation at enrolment in a 6-month open-label study with alfuzosin 10 mg once daily. Efficacy was analysed at the endpoint in the intent-to-treat population.

RESULTS

Of the 4857 men, 997 (20.5%) had pain/discomfort on ejaculation and 889/997 (89.2%) considered it was a problem. At inclusion, men with painful ejaculation had more severe LUTS and bother than men with LUTS only. Erectile dysfunction (ED) and reduced ejaculation were more prevalent (74.5% and 71.9%, respectively) and bothersome in men with painful ejaculation than in those with no pain (59.6% and 57.4%, respectively). Under alfuzosin treatment, all variables in both groups significantly improved from baseline; men with painful ejaculation compared to LUTS-only had similar improvements in weighted scores for LUTS (-7.8 vs -7.7), bother (-1.7 vs -1.7), and reduced ejaculate (-0.5 vs -0.4) but greater improvements in ED (-0.6 vs -0.4; P < 0.001). The weighted score for painful ejaculation decreased from 2.2 to 0.8 (P < 0.001). Alfuzosin was well tolerated in both groups.

CONCLUSIONS

This 6-month open-label study suggests that alfuzosin 10 mg once daily significantly improves LUTS, quality of life and sexual function in men with prostatitis-like symptoms, and is well tolerated.

Authors+Show Affiliations

Department of Urology, Queen's University, Kingston, ON, Canada. jcn@post.queensu.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16686719

Citation

Nickel, J Curtis, et al. "The Beneficial Effect of Alfuzosin 10 Mg once Daily in 'real-life' Practice On Lower Urinary Tract Symptoms (LUTS), Quality of Life and Sexual Dysfunction in Men With LUTS and Painful Ejaculation." BJU International, vol. 97, no. 6, 2006, pp. 1242-6.
Nickel JC, Elhilali M, Emberton M, et al. The beneficial effect of alfuzosin 10 mg once daily in 'real-life' practice on lower urinary tract symptoms (LUTS), quality of life and sexual dysfunction in men with LUTS and painful ejaculation. BJU Int. 2006;97(6):1242-6.
Nickel, J. C., Elhilali, M., Emberton, M., & Vallancien, G. (2006). The beneficial effect of alfuzosin 10 mg once daily in 'real-life' practice on lower urinary tract symptoms (LUTS), quality of life and sexual dysfunction in men with LUTS and painful ejaculation. BJU International, 97(6), 1242-6.
Nickel JC, et al. The Beneficial Effect of Alfuzosin 10 Mg once Daily in 'real-life' Practice On Lower Urinary Tract Symptoms (LUTS), Quality of Life and Sexual Dysfunction in Men With LUTS and Painful Ejaculation. BJU Int. 2006;97(6):1242-6. PubMed PMID: 16686719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The beneficial effect of alfuzosin 10 mg once daily in 'real-life' practice on lower urinary tract symptoms (LUTS), quality of life and sexual dysfunction in men with LUTS and painful ejaculation. AU - Nickel,J Curtis, AU - Elhilali,Mostafa, AU - Emberton,Mark, AU - Vallancien,Guy, AU - ,, PY - 2006/5/12/pubmed PY - 2006/6/29/medline PY - 2006/5/12/entrez SP - 1242 EP - 6 JF - BJU international JO - BJU Int VL - 97 IS - 6 N2 - OBJECTIVE: To determine the efficacy and safety of the selective alpha(1)-blocker alfuzosin in men with lower urinary tract symptoms (LUTS) and painful ejaculation, compared with those with LUTS only, as painful ejaculation is one of the most prevalent, differentiating and bothersome symptoms in men with chronic prostatitis/chronic pelvic pain syndrome. PATIENTS AND METHODS: In all, 4857 sexually active men with LUTS had an evaluable answer to the Danish Prostate Symptom Score for Sexual Symptoms question related to pain/discomfort on ejaculation at enrolment in a 6-month open-label study with alfuzosin 10 mg once daily. Efficacy was analysed at the endpoint in the intent-to-treat population. RESULTS: Of the 4857 men, 997 (20.5%) had pain/discomfort on ejaculation and 889/997 (89.2%) considered it was a problem. At inclusion, men with painful ejaculation had more severe LUTS and bother than men with LUTS only. Erectile dysfunction (ED) and reduced ejaculation were more prevalent (74.5% and 71.9%, respectively) and bothersome in men with painful ejaculation than in those with no pain (59.6% and 57.4%, respectively). Under alfuzosin treatment, all variables in both groups significantly improved from baseline; men with painful ejaculation compared to LUTS-only had similar improvements in weighted scores for LUTS (-7.8 vs -7.7), bother (-1.7 vs -1.7), and reduced ejaculate (-0.5 vs -0.4) but greater improvements in ED (-0.6 vs -0.4; P < 0.001). The weighted score for painful ejaculation decreased from 2.2 to 0.8 (P < 0.001). Alfuzosin was well tolerated in both groups. CONCLUSIONS: This 6-month open-label study suggests that alfuzosin 10 mg once daily significantly improves LUTS, quality of life and sexual function in men with prostatitis-like symptoms, and is well tolerated. SN - 1464-4096 UR - https://www.unboundmedicine.com/medline/citation/16686719/The_beneficial_effect_of_alfuzosin_10_mg_once_daily_in_'real_life'_practice_on_lower_urinary_tract_symptoms__LUTS__quality_of_life_and_sexual_dysfunction_in_men_with_LUTS_and_painful_ejaculation_ DB - PRIME DP - Unbound Medicine ER -