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Time course of the enhancement and restoration of the analgesic efficacy of codeine and morphine by delta9-tetrahydrocannabinol.
Eur J Pharmacol. 2006 Jun 06; 539(1-2):57-63.EJ

Abstract

Delta9-tetrahydrocannabinol (delta9-THC) synergizes with morphine and codeine by releasing endogenous opioids. These studies determined 1) the duration of enhancement of morphine and codeine by delta9-THC, 2) the effect of (delta9-THC on the time course of fully efficacious doses of the opioids, 3) restoration of efficacy of morphine and codeine by delta9-THC, and 4) duration of restoration. Sub-active combination doses of delta9-THC/morphine or delta9-THC/codeine are equivalent in duration of action and efficacy to high-dose opioids alone. Delta9-THC (20 mg/kg p.o.) significantly restores the antinociceptive effects of both high-dose morphine and codeine (100 and 200 mg/kg p.o., respectively) at later time points at which morphine or codeine was no longer active (360- and 120-min post-administration, respectively). Thus, the cannabinoid/opioid combination might be useful in therapeutics to enhance opioid activity, as well as to restore the efficacy of opioids.

Authors+Show Affiliations

Department of Pharmacology and Toxicology and School of Nurse Anesthesia, Virginia Commonwealth University MCV Campus, Richmond, VA 23298, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16687136

Citation

Williams, I Jovan, et al. "Time Course of the Enhancement and Restoration of the Analgesic Efficacy of Codeine and Morphine By Delta9-tetrahydrocannabinol." European Journal of Pharmacology, vol. 539, no. 1-2, 2006, pp. 57-63.
Williams IJ, Edwards S, Rubo A, et al. Time course of the enhancement and restoration of the analgesic efficacy of codeine and morphine by delta9-tetrahydrocannabinol. Eur J Pharmacol. 2006;539(1-2):57-63.
Williams, I. J., Edwards, S., Rubo, A., Haller, V. L., Stevens, D. L., & Welch, S. P. (2006). Time course of the enhancement and restoration of the analgesic efficacy of codeine and morphine by delta9-tetrahydrocannabinol. European Journal of Pharmacology, 539(1-2), 57-63.
Williams IJ, et al. Time Course of the Enhancement and Restoration of the Analgesic Efficacy of Codeine and Morphine By Delta9-tetrahydrocannabinol. Eur J Pharmacol. 2006 Jun 6;539(1-2):57-63. PubMed PMID: 16687136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time course of the enhancement and restoration of the analgesic efficacy of codeine and morphine by delta9-tetrahydrocannabinol. AU - Williams,I Jovan, AU - Edwards,Sherita, AU - Rubo,Alex, AU - Haller,Victoria L, AU - Stevens,David L, AU - Welch,Sandra P, Y1 - 2006/04/06/ PY - 2005/12/20/received PY - 2006/03/30/revised PY - 2006/04/03/accepted PY - 2006/5/12/pubmed PY - 2006/8/15/medline PY - 2006/5/12/entrez SP - 57 EP - 63 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 539 IS - 1-2 N2 - Delta9-tetrahydrocannabinol (delta9-THC) synergizes with morphine and codeine by releasing endogenous opioids. These studies determined 1) the duration of enhancement of morphine and codeine by delta9-THC, 2) the effect of (delta9-THC on the time course of fully efficacious doses of the opioids, 3) restoration of efficacy of morphine and codeine by delta9-THC, and 4) duration of restoration. Sub-active combination doses of delta9-THC/morphine or delta9-THC/codeine are equivalent in duration of action and efficacy to high-dose opioids alone. Delta9-THC (20 mg/kg p.o.) significantly restores the antinociceptive effects of both high-dose morphine and codeine (100 and 200 mg/kg p.o., respectively) at later time points at which morphine or codeine was no longer active (360- and 120-min post-administration, respectively). Thus, the cannabinoid/opioid combination might be useful in therapeutics to enhance opioid activity, as well as to restore the efficacy of opioids. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16687136/Time_course_of_the_enhancement_and_restoration_of_the_analgesic_efficacy_of_codeine_and_morphine_by_delta9_tetrahydrocannabinol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(06)00395-5 DB - PRIME DP - Unbound Medicine ER -