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Suppression of interleukin-6 by minocycline in a rat model of neuropathic pain.
Eur J Pharmacol. 2006 May 24; 538(1-3):66-72.EJ

Abstract

Inflammatory mediators produced in the injured nerve have been proposed as contributing factors in the development of neuropathic pain. In this regard an important role is assigned to interleukin-6. The present study, evaluated the effect of pretreatment with minocycline, on pain behavior (hyperalgesia and allodynia) and serum level of interleukin-6 in chronic constriction injury (CCI) model of neuropathic pain in rat. Minocycline (5, 10, 20 and 40 mg/kg, i.p.) was injected 1 h before surgery and continued daily to day 14 post-ligation. Behavioral tests were recorded before surgery and on postoperative days 1, 3, 5, 7, 9, 10, 14, and the serum concentration of interleukin-6 was determined at day 14. We observed that minocycline which was reported to have a neuroprotective effect in some neurodegenerative diseases, reversed hyperalgesia and allodynia due to sciatic nerve ligation and inhibited the interleukin-6 production. It seems that minocycline could have an anti-inflammatory and analgesic effect in some chronic pain states.

Authors+Show Affiliations

Shahid Baheshti University of Medical Sciences, Department of Pharmacology and Neuroscience Research Center, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16687137

Citation

Zanjani, Taraneh Moini, et al. "Suppression of Interleukin-6 By Minocycline in a Rat Model of Neuropathic Pain." European Journal of Pharmacology, vol. 538, no. 1-3, 2006, pp. 66-72.
Zanjani TM, Sabetkasaei M, Mosaffa N, et al. Suppression of interleukin-6 by minocycline in a rat model of neuropathic pain. Eur J Pharmacol. 2006;538(1-3):66-72.
Zanjani, T. M., Sabetkasaei, M., Mosaffa, N., Manaheji, H., Labibi, F., & Farokhi, B. (2006). Suppression of interleukin-6 by minocycline in a rat model of neuropathic pain. European Journal of Pharmacology, 538(1-3), 66-72.
Zanjani TM, et al. Suppression of Interleukin-6 By Minocycline in a Rat Model of Neuropathic Pain. Eur J Pharmacol. 2006 May 24;538(1-3):66-72. PubMed PMID: 16687137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of interleukin-6 by minocycline in a rat model of neuropathic pain. AU - Zanjani,Taraneh Moini, AU - Sabetkasaei,Masoumeh, AU - Mosaffa,Nariman, AU - Manaheji,Homa, AU - Labibi,Farzaneh, AU - Farokhi,Babak, Y1 - 2006/04/05/ PY - 2005/12/10/received PY - 2006/02/24/revised PY - 2006/03/28/accepted PY - 2006/5/12/pubmed PY - 2006/8/17/medline PY - 2006/5/12/entrez SP - 66 EP - 72 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 538 IS - 1-3 N2 - Inflammatory mediators produced in the injured nerve have been proposed as contributing factors in the development of neuropathic pain. In this regard an important role is assigned to interleukin-6. The present study, evaluated the effect of pretreatment with minocycline, on pain behavior (hyperalgesia and allodynia) and serum level of interleukin-6 in chronic constriction injury (CCI) model of neuropathic pain in rat. Minocycline (5, 10, 20 and 40 mg/kg, i.p.) was injected 1 h before surgery and continued daily to day 14 post-ligation. Behavioral tests were recorded before surgery and on postoperative days 1, 3, 5, 7, 9, 10, 14, and the serum concentration of interleukin-6 was determined at day 14. We observed that minocycline which was reported to have a neuroprotective effect in some neurodegenerative diseases, reversed hyperalgesia and allodynia due to sciatic nerve ligation and inhibited the interleukin-6 production. It seems that minocycline could have an anti-inflammatory and analgesic effect in some chronic pain states. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16687137/Suppression_of_interleukin_6_by_minocycline_in_a_rat_model_of_neuropathic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(06)00357-8 DB - PRIME DP - Unbound Medicine ER -