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From spreading depression to the trigeminovascular system.
Neurol Sci 2006; 27 Suppl 2:S86-90NS

Abstract

Migraine headaches have a complex pathophysiology; both vascular and neuronal mechanisms have been proposed. One possible scenario begins with brain-initiated events evolving to cortical spreading depression (CSD), which in turn activates the trigeminal nerve to cause headaches. Experimental evidence supports a relationship between CSD as a cause of migraine aura as well as CSD as a cause of trigeminal activation. Susceptibility to CSD and to migraine appears to be genetically determined. In some migraine subtypes, genes controlling translocation of calcium, sodium and potassium have been implicated, perhaps altering the susceptibility to CSD. This chapter briefly reviews current knowledge pertaining to migraine pathophysiology with emphasis on current notions linking disturbances in ion flux to the genesis of headache.

Authors+Show Affiliations

Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16688636

Citation

Dalkara, T, et al. "From Spreading Depression to the Trigeminovascular System." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 27 Suppl 2, 2006, pp. S86-90.
Dalkara T, Zervas NT, Moskowitz MA. From spreading depression to the trigeminovascular system. Neurol Sci. 2006;27 Suppl 2:S86-90.
Dalkara, T., Zervas, N. T., & Moskowitz, M. A. (2006). From spreading depression to the trigeminovascular system. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 27 Suppl 2, pp. S86-90.
Dalkara T, Zervas NT, Moskowitz MA. From Spreading Depression to the Trigeminovascular System. Neurol Sci. 2006;27 Suppl 2:S86-90. PubMed PMID: 16688636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From spreading depression to the trigeminovascular system. AU - Dalkara,T, AU - Zervas,N T, AU - Moskowitz,M A, PY - 2006/5/12/pubmed PY - 2006/7/27/medline PY - 2006/5/12/entrez SP - S86 EP - 90 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol. Sci. VL - 27 Suppl 2 N2 - Migraine headaches have a complex pathophysiology; both vascular and neuronal mechanisms have been proposed. One possible scenario begins with brain-initiated events evolving to cortical spreading depression (CSD), which in turn activates the trigeminal nerve to cause headaches. Experimental evidence supports a relationship between CSD as a cause of migraine aura as well as CSD as a cause of trigeminal activation. Susceptibility to CSD and to migraine appears to be genetically determined. In some migraine subtypes, genes controlling translocation of calcium, sodium and potassium have been implicated, perhaps altering the susceptibility to CSD. This chapter briefly reviews current knowledge pertaining to migraine pathophysiology with emphasis on current notions linking disturbances in ion flux to the genesis of headache. SN - 1590-1874 UR - https://www.unboundmedicine.com/medline/citation/16688636/From_spreading_depression_to_the_trigeminovascular_system_ L2 - https://dx.doi.org/10.1007/s10072-006-0577-z DB - PRIME DP - Unbound Medicine ER -