Tags

Type your tag names separated by a space and hit enter

The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens.
Virology. 2006 Aug 01; 351(2):303-11.V

Abstract

H5N1 avian influenza viruses are continuing to spread in waterfowl in Eurasia and to threaten the health of avian and mammalian species. The possibility that highly pathogenic (HP) H5N1 avian influenza is now endemic in both domestic and migratory birds in Eurasia makes it unlikely that culling alone will control H5N1 influenza. Because ducks are not uniformly killed by HP H5N1 viruses, they are considered a major contributor to virus spread. Here, we describe a reverse genetics-derived high-growth H5N3 strain containing the modified H5 of A/chicken/Vietnam/C58/04, the N3 of A/duck/Germany/1215/73, and the internal genes of A/PR/8/34. One or two doses of inactivated oil emulsion vaccine containing 0.015 to 1.2 microg of HA protein provide highly efficacious protection against lethal H5N1 challenge in ducks; only the two dose regimen has so far been tested in chickens with high protective efficacy.

Authors+Show Affiliations

St. Jude Children's Research Hospital, Department of Infectious Diseases, Division of Virology, 332 N. Lauderdale, Memphis, TN 38105, USA. robert.webster@stjude.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16690097

Citation

Webster, Robert G., et al. "The Immunogenicity and Efficacy Against H5N1 Challenge of Reverse Genetics-derived H5N3 Influenza Vaccine in Ducks and Chickens." Virology, vol. 351, no. 2, 2006, pp. 303-11.
Webster RG, Webby RJ, Hoffmann E, et al. The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens. Virology. 2006;351(2):303-11.
Webster, R. G., Webby, R. J., Hoffmann, E., Rodenberg, J., Kumar, M., Chu, H. J., Seiler, P., Krauss, S., & Songserm, T. (2006). The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens. Virology, 351(2), 303-11.
Webster RG, et al. The Immunogenicity and Efficacy Against H5N1 Challenge of Reverse Genetics-derived H5N3 Influenza Vaccine in Ducks and Chickens. Virology. 2006 Aug 1;351(2):303-11. PubMed PMID: 16690097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens. AU - Webster,Robert G, AU - Webby,Richard J, AU - Hoffmann,Erich, AU - Rodenberg,Jeff, AU - Kumar,Mahesh, AU - Chu,Hsien-Jue, AU - Seiler,Patrick, AU - Krauss,Scott, AU - Songserm,Thaweesak, Y1 - 2006/05/11/ PY - 2005/11/23/received PY - 2005/12/22/revised PY - 2006/01/30/accepted PY - 2006/5/13/pubmed PY - 2006/9/20/medline PY - 2006/5/13/entrez SP - 303 EP - 11 JF - Virology JO - Virology VL - 351 IS - 2 N2 - H5N1 avian influenza viruses are continuing to spread in waterfowl in Eurasia and to threaten the health of avian and mammalian species. The possibility that highly pathogenic (HP) H5N1 avian influenza is now endemic in both domestic and migratory birds in Eurasia makes it unlikely that culling alone will control H5N1 influenza. Because ducks are not uniformly killed by HP H5N1 viruses, they are considered a major contributor to virus spread. Here, we describe a reverse genetics-derived high-growth H5N3 strain containing the modified H5 of A/chicken/Vietnam/C58/04, the N3 of A/duck/Germany/1215/73, and the internal genes of A/PR/8/34. One or two doses of inactivated oil emulsion vaccine containing 0.015 to 1.2 microg of HA protein provide highly efficacious protection against lethal H5N1 challenge in ducks; only the two dose regimen has so far been tested in chickens with high protective efficacy. SN - 0042-6822 UR - https://www.unboundmedicine.com/medline/citation/16690097/The_immunogenicity_and_efficacy_against_H5N1_challenge_of_reverse_genetics_derived_H5N3_influenza_vaccine_in_ducks_and_chickens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(06)00075-4 DB - PRIME DP - Unbound Medicine ER -