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Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma.
Am J Clin Pathol. 2006 Jun; 125(6):860-5.AJ

Abstract

We evaluated epidermal growth factor receptor (EGFR) protein expression by immunohistochemical analysis and EGFR gene amplification by fluorescence in situ hybridization in 199 consecutive newly diagnosed and surgically treated patients with primary non-small cell lung carcinoma (NSCLC) and correlated results with clinicopathologic findings. EGFR protein expression was more common in squamous cell carcinoma (SCC; 17 [26.2%]) than in adenocarcinoma (14 [11.1%]; (P = .0076) and more frequently associated with EGFR amplification (8 [14.5%] vs 4 [3.6%] cases; P = .0208). Poor differentiation was associated with a higher average number of EGFR gene copies per cell (mean, 4.18; P = .0322) and a higher EGFR/chromosome 7 ratio (mean, 1.84; P = .0324). N0 disease showed a higher number of EGFR gene copies (mean, 4.196; P = .0163). SCCs demonstrated a higher EGFR/chromosome 7 ratio than adenocarcinomas (mean, 1.95 vs 1.47; P = .0324), particularly T1 tumors (mean, 1.79; P = .0243). Statistical analysis failed to show correlation between outcome and EGFR protein expression and gene amplification in early NSCLC. EGFR protein expression was uncoupled from gene amplification in most cases, although good correlation occurred in a subset of SCCs.

Authors+Show Affiliations

Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16690485

Citation

Dacic, Sanja, et al. "Significance of EGFR Protein Expression and Gene Amplification in Non-small Cell Lung Carcinoma." American Journal of Clinical Pathology, vol. 125, no. 6, 2006, pp. 860-5.
Dacic S, Flanagan M, Cieply K, et al. Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma. Am J Clin Pathol. 2006;125(6):860-5.
Dacic, S., Flanagan, M., Cieply, K., Ramalingam, S., Luketich, J., Belani, C., & Yousem, S. A. (2006). Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma. American Journal of Clinical Pathology, 125(6), 860-5.
Dacic S, et al. Significance of EGFR Protein Expression and Gene Amplification in Non-small Cell Lung Carcinoma. Am J Clin Pathol. 2006;125(6):860-5. PubMed PMID: 16690485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma. AU - Dacic,Sanja, AU - Flanagan,Melina, AU - Cieply,Kathleen, AU - Ramalingam,Suresh, AU - Luketich,James, AU - Belani,Chandra, AU - Yousem,Samuel A, PY - 2006/5/13/pubmed PY - 2006/6/21/medline PY - 2006/5/13/entrez SP - 860 EP - 5 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 125 IS - 6 N2 - We evaluated epidermal growth factor receptor (EGFR) protein expression by immunohistochemical analysis and EGFR gene amplification by fluorescence in situ hybridization in 199 consecutive newly diagnosed and surgically treated patients with primary non-small cell lung carcinoma (NSCLC) and correlated results with clinicopathologic findings. EGFR protein expression was more common in squamous cell carcinoma (SCC; 17 [26.2%]) than in adenocarcinoma (14 [11.1%]; (P = .0076) and more frequently associated with EGFR amplification (8 [14.5%] vs 4 [3.6%] cases; P = .0208). Poor differentiation was associated with a higher average number of EGFR gene copies per cell (mean, 4.18; P = .0322) and a higher EGFR/chromosome 7 ratio (mean, 1.84; P = .0324). N0 disease showed a higher number of EGFR gene copies (mean, 4.196; P = .0163). SCCs demonstrated a higher EGFR/chromosome 7 ratio than adenocarcinomas (mean, 1.95 vs 1.47; P = .0324), particularly T1 tumors (mean, 1.79; P = .0243). Statistical analysis failed to show correlation between outcome and EGFR protein expression and gene amplification in early NSCLC. EGFR protein expression was uncoupled from gene amplification in most cases, although good correlation occurred in a subset of SCCs. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/16690485/Significance_of_EGFR_protein_expression_and_gene_amplification_in_non_small_cell_lung_carcinoma_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/H5UW-6CPC-WWC9-2241 DB - PRIME DP - Unbound Medicine ER -