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Magnesium sulfate effectively reduces blood pressure in an animal model of preeclampsia.
J Matern Fetal Neonatal Med. 2006 Mar; 19(3):171-6.JM

Abstract

OBJECTIVE

We tested the ability of magnesium sulfate to reduce hypertension and neonatal growth retardation in an animal model of preeclampsia.

STUDY DESIGN

On day 17 of pregnancy, osmotic minipumps were inserted subcutaneously to continuously deliver either vehicle (saline control group), or N-nitro-L-arginine methyl ester (L-NAME) (50 mg/kg/day), or L-NAME (50 mg/kg/day) in combination with magnesium sulfate (60 mg/kg/day). Prior to insertion, blood pressure and heart rate were monitored with a pneumatic tail cuff device. Blood pressure measurements were repeated on days 18, 20, and 21 of pregnancy. Blood was obtained on days 17 and 21, along with urine, to assess magnesium levels and degree of proteinuria. Pups were weighed and measured at 48 hours postpartum.

RESULTS

Rats receiving L-NAME developed hypertension within 24 hours of implantation (108 +/- 3.9 vs. 123 +/- 3.4 mmHg, p < 0.05). Magnesium sulfate, given along with L-NAME did not prevent mean blood pressure from increasing, but reduced it by day 21 compared to L-NAME given alone (107 +/- 3.4 vs. 122 +/- 8.7 mmHg, respectively, p < 0.05). Magnesium sulfate reduced neonatal growth retardation by improving the weight of the pups compared to pups from maternal rats given L-NAME alone (6.1 +/- 0.1 vs. 5.2 +/- 0.3 grams, respectively, p < 0.05).

CONCLUSION

Maternal magnesium sulfate reduces blood pressure and increases neonatal size compared to L-NAME without magnesium. These findings support a beneficial effect of magnesium in preeclampsia.

Authors+Show Affiliations

Division of Physiology, Midwestern University, Arizona College of Osteopathic Medicine, Glendale, 85308, USA. cstand@midwestern.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16690511

Citation

Standley, Cynthia A., et al. "Magnesium Sulfate Effectively Reduces Blood Pressure in an Animal Model of Preeclampsia." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 19, no. 3, 2006, pp. 171-6.
Standley CA, Batia L, Yueh G. Magnesium sulfate effectively reduces blood pressure in an animal model of preeclampsia. J Matern Fetal Neonatal Med. 2006;19(3):171-6.
Standley, C. A., Batia, L., & Yueh, G. (2006). Magnesium sulfate effectively reduces blood pressure in an animal model of preeclampsia. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 19(3), 171-6.
Standley CA, Batia L, Yueh G. Magnesium Sulfate Effectively Reduces Blood Pressure in an Animal Model of Preeclampsia. J Matern Fetal Neonatal Med. 2006;19(3):171-6. PubMed PMID: 16690511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium sulfate effectively reduces blood pressure in an animal model of preeclampsia. AU - Standley,Cynthia A, AU - Batia,Lyn, AU - Yueh,Gloria, PY - 2006/5/13/pubmed PY - 2006/12/9/medline PY - 2006/5/13/entrez SP - 171 EP - 6 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J Matern Fetal Neonatal Med VL - 19 IS - 3 N2 - OBJECTIVE: We tested the ability of magnesium sulfate to reduce hypertension and neonatal growth retardation in an animal model of preeclampsia. STUDY DESIGN: On day 17 of pregnancy, osmotic minipumps were inserted subcutaneously to continuously deliver either vehicle (saline control group), or N-nitro-L-arginine methyl ester (L-NAME) (50 mg/kg/day), or L-NAME (50 mg/kg/day) in combination with magnesium sulfate (60 mg/kg/day). Prior to insertion, blood pressure and heart rate were monitored with a pneumatic tail cuff device. Blood pressure measurements were repeated on days 18, 20, and 21 of pregnancy. Blood was obtained on days 17 and 21, along with urine, to assess magnesium levels and degree of proteinuria. Pups were weighed and measured at 48 hours postpartum. RESULTS: Rats receiving L-NAME developed hypertension within 24 hours of implantation (108 +/- 3.9 vs. 123 +/- 3.4 mmHg, p < 0.05). Magnesium sulfate, given along with L-NAME did not prevent mean blood pressure from increasing, but reduced it by day 21 compared to L-NAME given alone (107 +/- 3.4 vs. 122 +/- 8.7 mmHg, respectively, p < 0.05). Magnesium sulfate reduced neonatal growth retardation by improving the weight of the pups compared to pups from maternal rats given L-NAME alone (6.1 +/- 0.1 vs. 5.2 +/- 0.3 grams, respectively, p < 0.05). CONCLUSION: Maternal magnesium sulfate reduces blood pressure and increases neonatal size compared to L-NAME without magnesium. These findings support a beneficial effect of magnesium in preeclampsia. SN - 1476-7058 UR - https://www.unboundmedicine.com/medline/citation/16690511/Magnesium_sulfate_effectively_reduces_blood_pressure_in_an_animal_model_of_preeclampsia_ L2 - https://www.tandfonline.com/doi/full/10.1080/14767050500448005 DB - PRIME DP - Unbound Medicine ER -