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Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats.
Pediatr Res. 2006 Jul; 60(1):77-82.PR

Abstract

Angiotensin II-forming chymase is expressed in the pulmonary arteries of the monocrotaline-induced pulmonary hypertensive rats, but its actual role is unclear. We studied chymase-dependent angiotensin II formation in the pulmonary arteries of the monocrotaline-induced pulmonary hypertensive rats and observed the effects of an angiotensin II receptor blocker on vascular remodeling. Four weeks after the administration of monocrotaline (60 mg/kg, s.q.), echocardiographic, hemodynamic, morphometric and biochemical analyses were performed. Age-matched rats were used as controls. To evaluate the effects of an angiotensin II receptor blocker, 2 wk after beginning of monocrotaline treatment, the rats were given candesartan (10 mg/kg per day) or placebo for 2 wk. In the monocrotaline-induced pulmonary hypertensive rats, the elevated systolic pulmonary arterial pressure and right ventricular hypertrophy were observed. Medial hypertrophy of lung arterioles was also observed. Chymase activity and angiotensin II concentration, but not angiotensin-converting enzyme activity, were significantly increased in the lung. In the angiotensin II receptor blocker-treated group, both systolic pulmonary arterial pressure and right ventricular hypertrophy were significantly reduced, and arteriolar hypertrophy was also prevented. Thus, angiotensin II-forming chymase may play a role in the proliferation of the medial layer in the lung arterioles of monocrotaline-induced pulmonary hypertensive rats.

Authors+Show Affiliations

Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16690960

Citation

Kishi, Kanta, et al. "Role of Chymase-dependent Angiotensin II Formation in Monocrotaline-induced Pulmonary Hypertensive Rats." Pediatric Research, vol. 60, no. 1, 2006, pp. 77-82.
Kishi K, Jin D, Takai S, et al. Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats. Pediatr Res. 2006;60(1):77-82.
Kishi, K., Jin, D., Takai, S., Muramatsu, M., Katayama, H., Tamai, H., & Miyazaki, M. (2006). Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats. Pediatric Research, 60(1), 77-82.
Kishi K, et al. Role of Chymase-dependent Angiotensin II Formation in Monocrotaline-induced Pulmonary Hypertensive Rats. Pediatr Res. 2006;60(1):77-82. PubMed PMID: 16690960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats. AU - Kishi,Kanta, AU - Jin,Denan, AU - Takai,Shinji, AU - Muramatsu,Michiko, AU - Katayama,Hiroshi, AU - Tamai,Hiroshi, AU - Miyazaki,Mizuo, Y1 - 2006/05/11/ PY - 2006/5/13/pubmed PY - 2006/9/12/medline PY - 2006/5/13/entrez SP - 77 EP - 82 JF - Pediatric research JO - Pediatr Res VL - 60 IS - 1 N2 - Angiotensin II-forming chymase is expressed in the pulmonary arteries of the monocrotaline-induced pulmonary hypertensive rats, but its actual role is unclear. We studied chymase-dependent angiotensin II formation in the pulmonary arteries of the monocrotaline-induced pulmonary hypertensive rats and observed the effects of an angiotensin II receptor blocker on vascular remodeling. Four weeks after the administration of monocrotaline (60 mg/kg, s.q.), echocardiographic, hemodynamic, morphometric and biochemical analyses were performed. Age-matched rats were used as controls. To evaluate the effects of an angiotensin II receptor blocker, 2 wk after beginning of monocrotaline treatment, the rats were given candesartan (10 mg/kg per day) or placebo for 2 wk. In the monocrotaline-induced pulmonary hypertensive rats, the elevated systolic pulmonary arterial pressure and right ventricular hypertrophy were observed. Medial hypertrophy of lung arterioles was also observed. Chymase activity and angiotensin II concentration, but not angiotensin-converting enzyme activity, were significantly increased in the lung. In the angiotensin II receptor blocker-treated group, both systolic pulmonary arterial pressure and right ventricular hypertrophy were significantly reduced, and arteriolar hypertrophy was also prevented. Thus, angiotensin II-forming chymase may play a role in the proliferation of the medial layer in the lung arterioles of monocrotaline-induced pulmonary hypertensive rats. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/16690960/Role_of_chymase_dependent_angiotensin_II_formation_in_monocrotaline_induced_pulmonary_hypertensive_rats_ L2 - https://doi.org/10.1203/01.pdr.0000219431.45075.d9 DB - PRIME DP - Unbound Medicine ER -