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Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii.
FEMS Yeast Res. 2006 Jun; 6(4):599-607.FY

Abstract

Cryptococcus neoformans and Cryptococcus gattii are yeasts that cause meningoencephalitis, but that differ in host range and geographical distribution. Cryptococcus neoformans occurs world-wide and mostly infects immunocompromised patients, whereas C. gattii occurs mainly in (sub)tropical regions and infects healthy individuals. Anomalous C. neoformans strains were isolated from patients. These strains were found to be monokaryotic, and diploid or aneuploid. Amplified Fragment Length Polymorphism (AFLP) and sequence analyses indicated that AFLP genotypes 2 (C. neoformans) and 4 (C. gattii) were present. The strains were serologically BD. Mating- and serotype-specific PCR reactions showed that the strains were MATa-serotype D/MATalpha-serotype B. This study is the first to describe naturally occurring hybrids between C. neoformans and C. gattii.

Authors+Show Affiliations

Bovers M
CBS-Centraalbureau voor Schimmelcultures, Utrecht, the Netherlands.
Hagen F
No affiliation info available
Kuramae EE
No affiliation info available
Diaz MR
No affiliation info available
Spanjaard L
No affiliation info available
Dromer F
No affiliation info available
Hoogveld HL
No affiliation info available
Boekhout T
No affiliation info available

MeSH

AdultAnimalsCerebrospinal FluidCryptococcusCryptococcus neoformansGenotypeHumansHybridization, GeneticMaleMeningitis, CryptococcalMolecular Sequence DataPloidiesPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthSequence Analysis, DNASerotyping

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16696655

Citation

Bovers, Marjan, et al. "Unique Hybrids Between the Fungal Pathogens Cryptococcus Neoformans and Cryptococcus Gattii." FEMS Yeast Research, vol. 6, no. 4, 2006, pp. 599-607.
Bovers M, Hagen F, Kuramae EE, et al. Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii. FEMS Yeast Res. 2006;6(4):599-607.
Bovers, M., Hagen, F., Kuramae, E. E., Diaz, M. R., Spanjaard, L., Dromer, F., Hoogveld, H. L., & Boekhout, T. (2006). Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii. FEMS Yeast Research, 6(4), 599-607.
Bovers M, et al. Unique Hybrids Between the Fungal Pathogens Cryptococcus Neoformans and Cryptococcus Gattii. FEMS Yeast Res. 2006;6(4):599-607. PubMed PMID: 16696655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii. AU - Bovers,Marjan, AU - Hagen,Ferry, AU - Kuramae,Eiko E, AU - Diaz,Mara R, AU - Spanjaard,Lodewijk, AU - Dromer,Françoise, AU - Hoogveld,Hans L, AU - Boekhout,Teun, PY - 2006/5/16/pubmed PY - 2006/7/29/medline PY - 2006/5/16/entrez SP - 599 EP - 607 JF - FEMS yeast research JO - FEMS Yeast Res VL - 6 IS - 4 N2 - Cryptococcus neoformans and Cryptococcus gattii are yeasts that cause meningoencephalitis, but that differ in host range and geographical distribution. Cryptococcus neoformans occurs world-wide and mostly infects immunocompromised patients, whereas C. gattii occurs mainly in (sub)tropical regions and infects healthy individuals. Anomalous C. neoformans strains were isolated from patients. These strains were found to be monokaryotic, and diploid or aneuploid. Amplified Fragment Length Polymorphism (AFLP) and sequence analyses indicated that AFLP genotypes 2 (C. neoformans) and 4 (C. gattii) were present. The strains were serologically BD. Mating- and serotype-specific PCR reactions showed that the strains were MATa-serotype D/MATalpha-serotype B. This study is the first to describe naturally occurring hybrids between C. neoformans and C. gattii. SN - 1567-1356 UR - https://www.unboundmedicine.com/medline/citation/16696655/Unique_hybrids_between_the_fungal_pathogens_Cryptococcus_neoformans_and_Cryptococcus_gattii_ DB - PRIME DP - Unbound Medicine ER -