Tags

Type your tag names separated by a space and hit enter

Antifungal activity of Juniperus essential oils against dermatophyte, Aspergillus and Candida strains.
J Appl Microbiol. 2006 Jun; 100(6):1333-8.JA

Abstract

AIMS

The increasing resistance to antifungal compounds and the reduced number of available drugs led us to search therapeutic alternatives among aromatic plants and their essential oils, empirically used by antifungal proprieties. In this work the authors report on the antifungal activity of Juniperus essential oils (Juniperus communis ssp. alpina, J. oxycedrus ssp. oxycedrus and J. turbinata).

METHODS AND RESULTS

Antifungal activity was evaluated by determination of MIC and MLC values, using a macrodilution method (NCCLS protocols), on clinical and type strains of Candida, Aspergillus and dermatophytes. The composition of the oils was ascertained by GC and GC/MS analysis. All essential oils inhibited test dermatophyte strains. The oil from leaves of J. oxycedrus ssp. oxycedrus is the most active, with MIC and MLC values ranging from 0.08-0.16 microl ml(-1) to 0.08-0.32 microl ml(-1), respectively. This oil is mainly composed of alpha-pinene (65.5%) and delta-3-carene (5.7%).

CONCLUSIONS

J. oxycedrus ssp. oxycedrus leaf oil proved to be an emergent alternative as antifungal agent against dermatophyte strains. delta-3-Carene, was shown to be a fundamental compound for this activity.

SIGNIFICANCE AND IMPACT OF THE STUDY

Results support that essential oils or some of their constituents may be useful in the clinical management of fungal infections, justifying future clinical trials to validate their use as therapeutic alternatives for dermatophytosis.

Authors+Show Affiliations

Cavaleiro C
Laboratory Pharmacognosy, Faculty of Pharmacy/CEF, University of Coimbra, Coimbra, Portugal. cavaleir@ff.uc.pt
Pinto E
No affiliation info available
Gonçalves MJ
No affiliation info available
Salgueiro L
No affiliation info available

MeSH

AspergillosisAspergillusBicyclic MonoterpenesCandidaCandidiasisDermatomycosesHand DermatosesJuniperusMicrobial Sensitivity TestsMonoterpenesOils, VolatilePhytotherapyPlant Leaves

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16696681

Citation

Cavaleiro, C, et al. "Antifungal Activity of Juniperus Essential Oils Against Dermatophyte, Aspergillus and Candida Strains." Journal of Applied Microbiology, vol. 100, no. 6, 2006, pp. 1333-8.
Cavaleiro C, Pinto E, Gonçalves MJ, et al. Antifungal activity of Juniperus essential oils against dermatophyte, Aspergillus and Candida strains. J Appl Microbiol. 2006;100(6):1333-8.
Cavaleiro, C., Pinto, E., Gonçalves, M. J., & Salgueiro, L. (2006). Antifungal activity of Juniperus essential oils against dermatophyte, Aspergillus and Candida strains. Journal of Applied Microbiology, 100(6), 1333-8.
Cavaleiro C, et al. Antifungal Activity of Juniperus Essential Oils Against Dermatophyte, Aspergillus and Candida Strains. J Appl Microbiol. 2006;100(6):1333-8. PubMed PMID: 16696681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal activity of Juniperus essential oils against dermatophyte, Aspergillus and Candida strains. AU - Cavaleiro,C, AU - Pinto,E, AU - Gonçalves,M J, AU - Salgueiro,L, PY - 2006/5/16/pubmed PY - 2006/9/30/medline PY - 2006/5/16/entrez SP - 1333 EP - 8 JF - Journal of applied microbiology JO - J Appl Microbiol VL - 100 IS - 6 N2 - AIMS: The increasing resistance to antifungal compounds and the reduced number of available drugs led us to search therapeutic alternatives among aromatic plants and their essential oils, empirically used by antifungal proprieties. In this work the authors report on the antifungal activity of Juniperus essential oils (Juniperus communis ssp. alpina, J. oxycedrus ssp. oxycedrus and J. turbinata). METHODS AND RESULTS: Antifungal activity was evaluated by determination of MIC and MLC values, using a macrodilution method (NCCLS protocols), on clinical and type strains of Candida, Aspergillus and dermatophytes. The composition of the oils was ascertained by GC and GC/MS analysis. All essential oils inhibited test dermatophyte strains. The oil from leaves of J. oxycedrus ssp. oxycedrus is the most active, with MIC and MLC values ranging from 0.08-0.16 microl ml(-1) to 0.08-0.32 microl ml(-1), respectively. This oil is mainly composed of alpha-pinene (65.5%) and delta-3-carene (5.7%). CONCLUSIONS: J. oxycedrus ssp. oxycedrus leaf oil proved to be an emergent alternative as antifungal agent against dermatophyte strains. delta-3-Carene, was shown to be a fundamental compound for this activity. SIGNIFICANCE AND IMPACT OF THE STUDY: Results support that essential oils or some of their constituents may be useful in the clinical management of fungal infections, justifying future clinical trials to validate their use as therapeutic alternatives for dermatophytosis. SN - 1364-5072 UR - https://www.unboundmedicine.com/medline/citation/16696681/Antifungal_activity_of_Juniperus_essential_oils_against_dermatophyte_Aspergillus_and_Candida_strains_ DB - PRIME DP - Unbound Medicine ER -