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Alosetron: ischemic colitis and serious complications of constipation.
Am J Gastroenterol. 2006 May; 101(5):1080-3.AJ

Abstract

Drugs such as alosetron that modulate serotonin effects by stimulating or blocking its receptors may play an important role in the treatment of some patients with irritable bowel system. In the case of alosetron, a 5HT-3 antagonist, an analysis of data from randomized clinical trials and postmarketing experiences have demonstrated a causal relationship between this drug and ischemic colitis and serious complications of constipation. Because the mechanism(s) of drug-induced ischemic colitis and possibly other forms of intestinal ischemia associated with alosetron have not been elucidated, there is need to further assess risk with regard to patient susceptibility and other factors.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comment
Editorial

Language

eng

PubMed ID

16696787

Citation

Gallo-Torres, Hugo, et al. "Alosetron: Ischemic Colitis and Serious Complications of Constipation." The American Journal of Gastroenterology, vol. 101, no. 5, 2006, pp. 1080-3.
Gallo-Torres H, Brinker A, Avigan M. Alosetron: ischemic colitis and serious complications of constipation. Am J Gastroenterol. 2006;101(5):1080-3.
Gallo-Torres, H., Brinker, A., & Avigan, M. (2006). Alosetron: ischemic colitis and serious complications of constipation. The American Journal of Gastroenterology, 101(5), 1080-3.
Gallo-Torres H, Brinker A, Avigan M. Alosetron: Ischemic Colitis and Serious Complications of Constipation. Am J Gastroenterol. 2006;101(5):1080-3. PubMed PMID: 16696787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alosetron: ischemic colitis and serious complications of constipation. AU - Gallo-Torres,Hugo, AU - Brinker,Allen, AU - Avigan,Mark, PY - 2006/5/16/pubmed PY - 2006/6/7/medline PY - 2006/5/16/entrez SP - 1080 EP - 3 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 101 IS - 5 N2 - Drugs such as alosetron that modulate serotonin effects by stimulating or blocking its receptors may play an important role in the treatment of some patients with irritable bowel system. In the case of alosetron, a 5HT-3 antagonist, an analysis of data from randomized clinical trials and postmarketing experiences have demonstrated a causal relationship between this drug and ischemic colitis and serious complications of constipation. Because the mechanism(s) of drug-induced ischemic colitis and possibly other forms of intestinal ischemia associated with alosetron have not been elucidated, there is need to further assess risk with regard to patient susceptibility and other factors. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/16696787/Alosetron:_ischemic_colitis_and_serious_complications_of_constipation_ L2 - http://Insights.ovid.com/pubmed?pmid=16696787 DB - PRIME DP - Unbound Medicine ER -