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White wine and beer induce gastro-oesophageal reflux in patients with reflux disease.
Aliment Pharmacol Ther 2006; 23(11):1581-6AP

Abstract

BACKGROUND

An induction of gastro-oesophageal reflux has been reported after ingestion of alcoholic beverages in healthy volunteers. However, it is unknown whether reflux in gastro-oesophageal reflux disease patients will be enhanced by the ingestion of alcoholic beverages.

AIM

To investigate the effects of wine and beer on postprandial reflux in reflux patients.

METHODS

Twenty-five patients (reflux oesophagitis 15, non-erosive reflux disease 10; 18 men and seven women) drank 300-mL white wine (n = 17), 500-mL beer (n = 8), or identical amounts of tap water (controls) together with a standardized meal in a randomized order. pH-measurement was carried out during three postprandial hours by pH-metry and the percentage of time pH < 4 was calculated.

RESULTS

Both alcoholic beverages increased reflux compared with water [wine 23% (median), water 12%, P < 0.01; beer 25%, water 11%, P < 0.05]. Between wine and beer, no difference in reflux induction was obtained. The reflux induction was seen in patients with (23%, P < 0.01) and without reflux oesophagitis (22%, P < 0.05) and in both sexes (women 23%, men 25%, P < 0.05 each).

CONCLUSIONS

Ingestion of commonly consumed alcoholic beverages such as wine and beer induces gastro-oesophageal reflux in gastro-oesophageal reflux disease patients. Therefore, these patients should be advised to avoid the intake of large amounts (> or = 300 mL) of these beverages.

Authors+Show Affiliations

Department of Gastroenterology, Bogenhausen Hospital, Munich, Germany. christian.pehl@extern.lrz-muenchen.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16696806

Citation

Pehl, C, et al. "White Wine and Beer Induce Gastro-oesophageal Reflux in Patients With Reflux Disease." Alimentary Pharmacology & Therapeutics, vol. 23, no. 11, 2006, pp. 1581-6.
Pehl C, Wendl B, Pfeiffer A. White wine and beer induce gastro-oesophageal reflux in patients with reflux disease. Aliment Pharmacol Ther. 2006;23(11):1581-6.
Pehl, C., Wendl, B., & Pfeiffer, A. (2006). White wine and beer induce gastro-oesophageal reflux in patients with reflux disease. Alimentary Pharmacology & Therapeutics, 23(11), pp. 1581-6.
Pehl C, Wendl B, Pfeiffer A. White Wine and Beer Induce Gastro-oesophageal Reflux in Patients With Reflux Disease. Aliment Pharmacol Ther. 2006 Jun 1;23(11):1581-6. PubMed PMID: 16696806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White wine and beer induce gastro-oesophageal reflux in patients with reflux disease. AU - Pehl,C, AU - Wendl,B, AU - Pfeiffer,A, PY - 2006/5/16/pubmed PY - 2006/9/30/medline PY - 2006/5/16/entrez SP - 1581 EP - 6 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 23 IS - 11 N2 - BACKGROUND: An induction of gastro-oesophageal reflux has been reported after ingestion of alcoholic beverages in healthy volunteers. However, it is unknown whether reflux in gastro-oesophageal reflux disease patients will be enhanced by the ingestion of alcoholic beverages. AIM: To investigate the effects of wine and beer on postprandial reflux in reflux patients. METHODS: Twenty-five patients (reflux oesophagitis 15, non-erosive reflux disease 10; 18 men and seven women) drank 300-mL white wine (n = 17), 500-mL beer (n = 8), or identical amounts of tap water (controls) together with a standardized meal in a randomized order. pH-measurement was carried out during three postprandial hours by pH-metry and the percentage of time pH < 4 was calculated. RESULTS: Both alcoholic beverages increased reflux compared with water [wine 23% (median), water 12%, P < 0.01; beer 25%, water 11%, P < 0.05]. Between wine and beer, no difference in reflux induction was obtained. The reflux induction was seen in patients with (23%, P < 0.01) and without reflux oesophagitis (22%, P < 0.05) and in both sexes (women 23%, men 25%, P < 0.05 each). CONCLUSIONS: Ingestion of commonly consumed alcoholic beverages such as wine and beer induces gastro-oesophageal reflux in gastro-oesophageal reflux disease patients. Therefore, these patients should be advised to avoid the intake of large amounts (> or = 300 mL) of these beverages. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/16696806/White_wine_and_beer_induce_gastro_oesophageal_reflux_in_patients_with_reflux_disease_ L2 - https://doi.org/10.1111/j.1365-2036.2006.02922.x DB - PRIME DP - Unbound Medicine ER -