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Acarbose, an alpha-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation.
Biochem Biophys Res Commun. 2006 Jun 30; 345(2):688-93.BB

Abstract

Several epidemiological studies have revealed that subjects with postprandial hyperglycemia are at increased risk of cardiovascular disease. However, the impact of postprandial hyperglycemia and its treatment on endothelial function has not been clarified yet. In this study, Goto-Kakizaki (GK) rats, a non-obese type 2 diabetes model, fed twice daily were used as a model of repetitive postprandial glucose spikes. We investigated the endothelial function in these rats treated or untreated with acarbose, an alpha-glucosidase inhibitor. Administration of acarbose for 12 weeks markedly improved postprandial hyperglycemia, postprandial insulin level, total cholesterol, triglyceride, and free fatty acid level in GK rats. Furthermore, acarbose efficiently reduced the number of monocytes adherent to aortic endothelial layer, improved acetylcholine-dependent vasodilatation, and reduced intimal thickening of the aorta. While it is generally regarded that repetitive postprandial hyperglycemia is associated with the onset of cardiovascular diseases, our data demonstrated that acarbose treatment efficiently ameliorated endothelial dysfunction and reduced intimal thickening, thus adding support to the protective effect of acarbose against the onset of cardiovascular disease.

Authors+Show Affiliations

Department of Medicine, Metabolism and Endocrinology, Juntendo University, School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16696939

Citation

Azuma, Kosuke, et al. "Acarbose, an Alpha-glucosidase Inhibitor, Improves Endothelial Dysfunction in Goto-Kakizaki Rats Exhibiting Repetitive Blood Glucose Fluctuation." Biochemical and Biophysical Research Communications, vol. 345, no. 2, 2006, pp. 688-93.
Azuma K, Toyofuku Y, Iesaki T, et al. Acarbose, an alpha-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation. Biochem Biophys Res Commun. 2006;345(2):688-93.
Azuma, K., Toyofuku, Y., Iesaki, T., Otsuka, A., Tanaka, A., Mita, T., Hirose, T., Tanaka, Y., Daida, H., Kawamori, R., & Watada, H. (2006). Acarbose, an alpha-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation. Biochemical and Biophysical Research Communications, 345(2), 688-93.
Azuma K, et al. Acarbose, an Alpha-glucosidase Inhibitor, Improves Endothelial Dysfunction in Goto-Kakizaki Rats Exhibiting Repetitive Blood Glucose Fluctuation. Biochem Biophys Res Commun. 2006 Jun 30;345(2):688-93. PubMed PMID: 16696939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acarbose, an alpha-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation. AU - Azuma,Kosuke, AU - Toyofuku,Yukiko, AU - Iesaki,Takafumi, AU - Otsuka,Aiko, AU - Tanaka,Atsuko, AU - Mita,Tomoya, AU - Hirose,Takahisa, AU - Tanaka,Yasushi, AU - Daida,Hiroyuki, AU - Kawamori,Ryuzo, AU - Watada,Hirotaka, Y1 - 2006/05/02/ PY - 2006/03/27/received PY - 2006/04/14/accepted PY - 2006/5/16/pubmed PY - 2006/8/17/medline PY - 2006/5/16/entrez SP - 688 EP - 93 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 345 IS - 2 N2 - Several epidemiological studies have revealed that subjects with postprandial hyperglycemia are at increased risk of cardiovascular disease. However, the impact of postprandial hyperglycemia and its treatment on endothelial function has not been clarified yet. In this study, Goto-Kakizaki (GK) rats, a non-obese type 2 diabetes model, fed twice daily were used as a model of repetitive postprandial glucose spikes. We investigated the endothelial function in these rats treated or untreated with acarbose, an alpha-glucosidase inhibitor. Administration of acarbose for 12 weeks markedly improved postprandial hyperglycemia, postprandial insulin level, total cholesterol, triglyceride, and free fatty acid level in GK rats. Furthermore, acarbose efficiently reduced the number of monocytes adherent to aortic endothelial layer, improved acetylcholine-dependent vasodilatation, and reduced intimal thickening of the aorta. While it is generally regarded that repetitive postprandial hyperglycemia is associated with the onset of cardiovascular diseases, our data demonstrated that acarbose treatment efficiently ameliorated endothelial dysfunction and reduced intimal thickening, thus adding support to the protective effect of acarbose against the onset of cardiovascular disease. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16696939/Acarbose_an_alpha_glucosidase_inhibitor_improves_endothelial_dysfunction_in_Goto_Kakizaki_rats_exhibiting_repetitive_blood_glucose_fluctuation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(06)00910-7 DB - PRIME DP - Unbound Medicine ER -