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The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion.
Eur J Pharm Biopharm. 2006 Aug; 64(1):75-81.EJ

Abstract

The use of filler materials in an extended release monolithic polymer matrix can lead to a vastly altered release profile for the active pharmaceutical ingredient. A range of excipients for use in monolithic matrices have been discussed in the literature. The body of work described in this research paper outlines the use of agar as a novel filler material in a hot melt extruded polymer matrix. Several batches of matrix material were prepared with Diclofenac sodium used as the active pharmaceutical ingredient (API). Agar and microcrystalline cellulose were used as the filler materials in varying ratios, to examine the effect of % filler content as well as filler type on the properties of the hot melt extruded matrix. The resultant extrudates were characterised using steady state parallel plate rheometry, differential scanning calorimetry (DSC) and dissolution testing. The rheometry analysis concluded that the fillers used resulted in an increase in the matrix viscosity. The DSC scans obtained showed negligible effects on the melting behavior of the matrix as a result of the filler inclusion. Dissolution analysis showed that the presence of the fillers resulted in a slower release rate of API than for the matrix alone. The results detailed within this paper indicate that agar is a viable filler for extended release hot melt produced dosage forms.

Authors+Show Affiliations

Centre for Biopolymer and Biomolecular Research, Athlone Institute of Technology, Westmeath, Ireland. slyons@ait.ieNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16697170

Citation

Lyons, John G., et al. "The Use of Agar as a Novel Filler for Monolithic Matrices Produced Using Hot Melt Extrusion." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 64, no. 1, 2006, pp. 75-81.
Lyons JG, Devine DM, Kennedy JE, et al. The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion. Eur J Pharm Biopharm. 2006;64(1):75-81.
Lyons, J. G., Devine, D. M., Kennedy, J. E., Geever, L. M., O'Sullivan, P., & Higginbotham, C. L. (2006). The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 64(1), 75-81.
Lyons JG, et al. The Use of Agar as a Novel Filler for Monolithic Matrices Produced Using Hot Melt Extrusion. Eur J Pharm Biopharm. 2006;64(1):75-81. PubMed PMID: 16697170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion. AU - Lyons,John G, AU - Devine,Declan M, AU - Kennedy,James E, AU - Geever,Luke M, AU - O'Sullivan,Patrick, AU - Higginbotham,Clement L, Y1 - 2006/05/11/ PY - 2006/01/09/received PY - 2006/03/22/revised PY - 2006/03/23/accepted PY - 2006/5/16/pubmed PY - 2007/1/17/medline PY - 2006/5/16/entrez SP - 75 EP - 81 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 64 IS - 1 N2 - The use of filler materials in an extended release monolithic polymer matrix can lead to a vastly altered release profile for the active pharmaceutical ingredient. A range of excipients for use in monolithic matrices have been discussed in the literature. The body of work described in this research paper outlines the use of agar as a novel filler material in a hot melt extruded polymer matrix. Several batches of matrix material were prepared with Diclofenac sodium used as the active pharmaceutical ingredient (API). Agar and microcrystalline cellulose were used as the filler materials in varying ratios, to examine the effect of % filler content as well as filler type on the properties of the hot melt extruded matrix. The resultant extrudates were characterised using steady state parallel plate rheometry, differential scanning calorimetry (DSC) and dissolution testing. The rheometry analysis concluded that the fillers used resulted in an increase in the matrix viscosity. The DSC scans obtained showed negligible effects on the melting behavior of the matrix as a result of the filler inclusion. Dissolution analysis showed that the presence of the fillers resulted in a slower release rate of API than for the matrix alone. The results detailed within this paper indicate that agar is a viable filler for extended release hot melt produced dosage forms. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/16697170/The_use_of_agar_as_a_novel_filler_for_monolithic_matrices_produced_using_hot_melt_extrusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(06)00078-6 DB - PRIME DP - Unbound Medicine ER -