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Effects of algal extracts (Polysiphonia fucoides) on rainbow trout (Oncorhynchus mykiss): a biomarker approach.
Mar Environ Res. 2006 Jul; 62 Suppl:S283-6.ME

Abstract

The genotoxicity of algal extracts (Polysiphonia fucoides) was investigated in erythrocytes of rainbow trout (Oncorhynchus mykiss). Trout were exposed to 0.5% of the algal extract for 7 days. Comet assay (alkaline and neutral versions) and Micronucleus test were used to assess DNA damage, and Diffusion Assay to detect apoptotic cells. EROD activities and oxidative stress parameters in rainbow trout liver were also measured. A significant induction of DNA single strand breaks comparable to the ones induced by the in vivo exposure to 20 mg/kg B[a]P was observed at the end of the treatment, while increases of double strand breaks and apoptotic cells were not observed. The absence of activation of antioxidant responses seems to underline a mechanism of action of the genotoxic algal extract which does not involve oxidative stress.

Authors+Show Affiliations

Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16697459

Citation

Del Barga, I, et al. "Effects of Algal Extracts (Polysiphonia Fucoides) On Rainbow Trout (Oncorhynchus Mykiss): a Biomarker Approach." Marine Environmental Research, vol. 62 Suppl, 2006, pp. S283-6.
Del Barga I, Frenzilli G, Scarcelli V, et al. Effects of algal extracts (Polysiphonia fucoides) on rainbow trout (Oncorhynchus mykiss): a biomarker approach. Mar Environ Res. 2006;62 Suppl:S283-6.
Del Barga, I., Frenzilli, G., Scarcelli, V., Nigro, M., Malmvärn, A., Asplund, L., Förlin, L., & Sturve, J. (2006). Effects of algal extracts (Polysiphonia fucoides) on rainbow trout (Oncorhynchus mykiss): a biomarker approach. Marine Environmental Research, 62 Suppl, S283-6.
Del Barga I, et al. Effects of Algal Extracts (Polysiphonia Fucoides) On Rainbow Trout (Oncorhynchus Mykiss): a Biomarker Approach. Mar Environ Res. 2006;62 Suppl:S283-6. PubMed PMID: 16697459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of algal extracts (Polysiphonia fucoides) on rainbow trout (Oncorhynchus mykiss): a biomarker approach. AU - Del Barga,I, AU - Frenzilli,G, AU - Scarcelli,V, AU - Nigro,M, AU - Malmvärn,A, AU - Asplund,L, AU - Förlin,L, AU - Sturve,J, Y1 - 2006/04/18/ PY - 2006/5/16/pubmed PY - 2008/2/22/medline PY - 2006/5/16/entrez SP - S283 EP - 6 JF - Marine environmental research JO - Mar Environ Res VL - 62 Suppl N2 - The genotoxicity of algal extracts (Polysiphonia fucoides) was investigated in erythrocytes of rainbow trout (Oncorhynchus mykiss). Trout were exposed to 0.5% of the algal extract for 7 days. Comet assay (alkaline and neutral versions) and Micronucleus test were used to assess DNA damage, and Diffusion Assay to detect apoptotic cells. EROD activities and oxidative stress parameters in rainbow trout liver were also measured. A significant induction of DNA single strand breaks comparable to the ones induced by the in vivo exposure to 20 mg/kg B[a]P was observed at the end of the treatment, while increases of double strand breaks and apoptotic cells were not observed. The absence of activation of antioxidant responses seems to underline a mechanism of action of the genotoxic algal extract which does not involve oxidative stress. SN - 0141-1136 UR - https://www.unboundmedicine.com/medline/citation/16697459/Effects_of_algal_extracts__Polysiphonia_fucoides__on_rainbow_trout__Oncorhynchus_mykiss_:_a_biomarker_approach_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-1136(06)00067-5 DB - PRIME DP - Unbound Medicine ER -