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Sensing capability of the localized surface plasmon resonance of gold nanorods.
Biosens Bioelectron. 2007 Jan 15; 22(6):926-32.BB

Abstract

We demonstrate the feasibility of using the longitudinal component of gold nanorod's surface plasmon resonance in biomolecular sensing. The sensitive dependence of the absorption maximum on the dielectric constant of the particle interfacial region makes gold nanorods a promise for constructing a biomolecular sensing scheme. The sensor containing gold nanorods, with a mean aspect ratio of 5.2, exhibits a sensitivity of ca. 366 nm/RIU (refractive index unit), which increases accordingly with the increase of the particle mean aspect ratios. Such a biosensor was further modified to demonstrate its effectiveness in quantitative detection for selective binding events, such as biotin/streptavidin pairs, through a process in which biotin molecules were chemically attached to the gold nanorods' surface prior to detection measurements. Results showed that the spectral lambda(max) shifts linearly to the concentrations of the streptavidin. The results from both experiment and model calculations strongly indicate the efficacy of the longitudinal surface plasmon absorption band in biosensing.

Authors+Show Affiliations

Department of Chemistry and Biochemistry, National Chung Cheng University, 168 University Road, Min-Hsiung, Chia-Yi 621, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16697633

Citation

Chen, Cheng-Dah, et al. "Sensing Capability of the Localized Surface Plasmon Resonance of Gold Nanorods." Biosensors & Bioelectronics, vol. 22, no. 6, 2007, pp. 926-32.
Chen CD, Cheng SF, Chau LK, et al. Sensing capability of the localized surface plasmon resonance of gold nanorods. Biosens Bioelectron. 2007;22(6):926-32.
Chen, C. D., Cheng, S. F., Chau, L. K., & Wang, C. R. (2007). Sensing capability of the localized surface plasmon resonance of gold nanorods. Biosensors & Bioelectronics, 22(6), 926-32.
Chen CD, et al. Sensing Capability of the Localized Surface Plasmon Resonance of Gold Nanorods. Biosens Bioelectron. 2007 Jan 15;22(6):926-32. PubMed PMID: 16697633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensing capability of the localized surface plasmon resonance of gold nanorods. AU - Chen,Cheng-Dah, AU - Cheng,Shu-Fang, AU - Chau,Lai-Kwan, AU - Wang,C R Chris, Y1 - 2006/05/12/ PY - 2005/12/09/received PY - 2006/03/18/revised PY - 2006/03/22/accepted PY - 2006/5/16/pubmed PY - 2007/3/7/medline PY - 2006/5/16/entrez SP - 926 EP - 32 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 22 IS - 6 N2 - We demonstrate the feasibility of using the longitudinal component of gold nanorod's surface plasmon resonance in biomolecular sensing. The sensitive dependence of the absorption maximum on the dielectric constant of the particle interfacial region makes gold nanorods a promise for constructing a biomolecular sensing scheme. The sensor containing gold nanorods, with a mean aspect ratio of 5.2, exhibits a sensitivity of ca. 366 nm/RIU (refractive index unit), which increases accordingly with the increase of the particle mean aspect ratios. Such a biosensor was further modified to demonstrate its effectiveness in quantitative detection for selective binding events, such as biotin/streptavidin pairs, through a process in which biotin molecules were chemically attached to the gold nanorods' surface prior to detection measurements. Results showed that the spectral lambda(max) shifts linearly to the concentrations of the streptavidin. The results from both experiment and model calculations strongly indicate the efficacy of the longitudinal surface plasmon absorption band in biosensing. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/16697633/Sensing_capability_of_the_localized_surface_plasmon_resonance_of_gold_nanorods_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(06)00182-5 DB - PRIME DP - Unbound Medicine ER -