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Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection.
J Ethnopharmacol. 2006 Oct 11; 107(3):431-41.JE

Abstract

Several plants are used in folk medicine to treat gastrointestinal disorders. Mouriri pusa Gardn. (Melastomataceae) is a medicinal plant commonly used in the central region of Brazil against gastric ulcer. Two organic extracts methanolic (MeOH) and dichloromethane (DCM) obtained by sequential extraction from the leaves of Mouriri pusa were evaluated for their ability to protect the gastric mucosa against injuries caused by necrotizing agents (0.3M HCl/60% EtOH, absolute ethanol, non-steroidal anti-inflammatory drug, stress and pylorus ligature) in mice and rats. The best results were obtained after pretreatment with MeOH extract whereas the DCM extract did not show the same significant antiulcerogenic activity. No acute toxicity was observed in animals treated with 5 g/kg, p.o. of MeOH extract. The mechanism involving the antiulcerogenic action of MeOH extract seemed to be related to NO generation and also suggested the effective participation of endogenous sulfhydryl group in the gastroprotective action. Phytochemical investigation of the MeOH extract of Mouriri pusa yielded tannins, flavonoids and (-)-epicatechin. The presence of these phenolic compounds probably would explain the antiulcerogenic effect of the polar extract of Mouriri pusa leaves.

Authors+Show Affiliations

Departamento de Química Orgânica, Instituto de Química, CP 355, CEP 14801-970, UNESP, São Paulo State University, Araraquara, SP, Brasil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16698206

Citation

Andreo, Marcio Adriano, et al. "Effect of Mouriri Pusa Extracts On Experimentally Induced Gastric Lesions in Rodents: Role of Endogenous Sulfhydryls Compounds and Nitric Oxide in Gastroprotection." Journal of Ethnopharmacology, vol. 107, no. 3, 2006, pp. 431-41.
Andreo MA, Ballesteros KV, Hiruma-Lima CA, et al. Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection. J Ethnopharmacol. 2006;107(3):431-41.
Andreo, M. A., Ballesteros, K. V., Hiruma-Lima, C. A., Machado da Rocha, L. R., Souza Brito, A. R., & Vilegas, W. (2006). Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection. Journal of Ethnopharmacology, 107(3), 431-41.
Andreo MA, et al. Effect of Mouriri Pusa Extracts On Experimentally Induced Gastric Lesions in Rodents: Role of Endogenous Sulfhydryls Compounds and Nitric Oxide in Gastroprotection. J Ethnopharmacol. 2006 Oct 11;107(3):431-41. PubMed PMID: 16698206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection. AU - Andreo,Marcio Adriano, AU - Ballesteros,Kátia Verônica Rodríguez, AU - Hiruma-Lima,Clélia Akiko, AU - Machado da Rocha,Lúcia Regina, AU - Souza Brito,Alba Regina Monteiro, AU - Vilegas,Wagner, Y1 - 2006/04/15/ PY - 2005/07/08/received PY - 2006/03/20/revised PY - 2006/04/03/accepted PY - 2006/5/16/pubmed PY - 2007/1/27/medline PY - 2006/5/16/entrez SP - 431 EP - 41 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 107 IS - 3 N2 - Several plants are used in folk medicine to treat gastrointestinal disorders. Mouriri pusa Gardn. (Melastomataceae) is a medicinal plant commonly used in the central region of Brazil against gastric ulcer. Two organic extracts methanolic (MeOH) and dichloromethane (DCM) obtained by sequential extraction from the leaves of Mouriri pusa were evaluated for their ability to protect the gastric mucosa against injuries caused by necrotizing agents (0.3M HCl/60% EtOH, absolute ethanol, non-steroidal anti-inflammatory drug, stress and pylorus ligature) in mice and rats. The best results were obtained after pretreatment with MeOH extract whereas the DCM extract did not show the same significant antiulcerogenic activity. No acute toxicity was observed in animals treated with 5 g/kg, p.o. of MeOH extract. The mechanism involving the antiulcerogenic action of MeOH extract seemed to be related to NO generation and also suggested the effective participation of endogenous sulfhydryl group in the gastroprotective action. Phytochemical investigation of the MeOH extract of Mouriri pusa yielded tannins, flavonoids and (-)-epicatechin. The presence of these phenolic compounds probably would explain the antiulcerogenic effect of the polar extract of Mouriri pusa leaves. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16698206/Effect_of_Mouriri_pusa_extracts_on_experimentally_induced_gastric_lesions_in_rodents:_role_of_endogenous_sulfhydryls_compounds_and_nitric_oxide_in_gastroprotection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00181-4 DB - PRIME DP - Unbound Medicine ER -