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Active influenza immunization in hemodialysis patients: comparison between single-dose and booster vaccination.

Abstract

BACKGROUND/AIMS

Hemodialysis (HD) patients are recommended to be immunized against influenza annually, but the immune response after vaccination is known to be weakened in these patients. We intended to compare the efficacy of influenza vaccines in HD patients with that in healthy people, and we also evaluated the additive effect of a booster vaccination in HD patients.

METHODS

During the 2003-2004 influenza season, 100 patients on HD and 50 age-matched healthy controls were recruited from the Korea University Guro Hospital. The HD patients were divided into two groups: single-dose group (50 patients) and booster group (50 patients). Eight weeks following the influenza vaccination, the serum antibody responses were compared.

RESULTS

Although the antibody response of the HD patients was impaired in comparison with that of healthy controls, more than 90% of the HD patients showed protective antibody levels. Booster vaccination did not significantly increase the immune response in HD patients.

CONCLUSIONS

Influenza vaccination in HD patients should be encouraged, but the immune response was comparatively impaired in subpopulations, including patients with a long-term HD history (>2.5 years), with a higher urea reduction rate, or with underlying diabetes. There was no effect of a booster vaccine dose on the antibody titers.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Infectious Diseases, Department of Internal Medicine, Korea University Guro Hospital, Guro Gu, Seoul, Korea.

    , , , ,

    Source

    American journal of nephrology 26:2 2006 pg 206-11

    MeSH

    Adult
    Antibodies, Viral
    Female
    Hemagglutination Inhibition Tests
    Humans
    Immunity, Active
    Immunization, Secondary
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Renal Dialysis
    Vaccination

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    16699258

    Citation

    Song, Joon Young, et al. "Active Influenza Immunization in Hemodialysis Patients: Comparison Between Single-dose and Booster Vaccination." American Journal of Nephrology, vol. 26, no. 2, 2006, pp. 206-11.
    Song JY, Cheong HJ, Ha SH, et al. Active influenza immunization in hemodialysis patients: comparison between single-dose and booster vaccination. Am J Nephrol. 2006;26(2):206-11.
    Song, J. Y., Cheong, H. J., Ha, S. H., Kee, S. Y., Jeong, H. W., & Kim, W. J. (2006). Active influenza immunization in hemodialysis patients: comparison between single-dose and booster vaccination. American Journal of Nephrology, 26(2), pp. 206-11.
    Song JY, et al. Active Influenza Immunization in Hemodialysis Patients: Comparison Between Single-dose and Booster Vaccination. Am J Nephrol. 2006;26(2):206-11. PubMed PMID: 16699258.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Active influenza immunization in hemodialysis patients: comparison between single-dose and booster vaccination. AU - Song,Joon Young, AU - Cheong,Hee Jin, AU - Ha,Seok Hoon, AU - Kee,Sae Yoon, AU - Jeong,Hye Won, AU - Kim,Woo Joo, Y1 - 2006/05/11/ PY - 2006/02/06/received PY - 2006/04/11/accepted PY - 2006/5/16/pubmed PY - 2006/10/27/medline PY - 2006/5/16/entrez SP - 206 EP - 11 JF - American journal of nephrology JO - Am. J. Nephrol. VL - 26 IS - 2 N2 - BACKGROUND/AIMS: Hemodialysis (HD) patients are recommended to be immunized against influenza annually, but the immune response after vaccination is known to be weakened in these patients. We intended to compare the efficacy of influenza vaccines in HD patients with that in healthy people, and we also evaluated the additive effect of a booster vaccination in HD patients. METHODS: During the 2003-2004 influenza season, 100 patients on HD and 50 age-matched healthy controls were recruited from the Korea University Guro Hospital. The HD patients were divided into two groups: single-dose group (50 patients) and booster group (50 patients). Eight weeks following the influenza vaccination, the serum antibody responses were compared. RESULTS: Although the antibody response of the HD patients was impaired in comparison with that of healthy controls, more than 90% of the HD patients showed protective antibody levels. Booster vaccination did not significantly increase the immune response in HD patients. CONCLUSIONS: Influenza vaccination in HD patients should be encouraged, but the immune response was comparatively impaired in subpopulations, including patients with a long-term HD history (>2.5 years), with a higher urea reduction rate, or with underlying diabetes. There was no effect of a booster vaccine dose on the antibody titers. SN - 0250-8095 UR - https://www.unboundmedicine.com/medline/citation/16699258/Active_influenza_immunization_in_hemodialysis_patients:_comparison_between_single_dose_and_booster_vaccination_ L2 - https://www.karger.com?DOI=10.1159/000093306 DB - PRIME DP - Unbound Medicine ER -