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Active influenza immunization in hemodialysis patients: comparison between single-dose and booster vaccination.
Am J Nephrol 2006; 26(2):206-11AJ

Abstract

BACKGROUND/AIMS

Hemodialysis (HD) patients are recommended to be immunized against influenza annually, but the immune response after vaccination is known to be weakened in these patients. We intended to compare the efficacy of influenza vaccines in HD patients with that in healthy people, and we also evaluated the additive effect of a booster vaccination in HD patients.

METHODS

During the 2003-2004 influenza season, 100 patients on HD and 50 age-matched healthy controls were recruited from the Korea University Guro Hospital. The HD patients were divided into two groups: single-dose group (50 patients) and booster group (50 patients). Eight weeks following the influenza vaccination, the serum antibody responses were compared.

RESULTS

Although the antibody response of the HD patients was impaired in comparison with that of healthy controls, more than 90% of the HD patients showed protective antibody levels. Booster vaccination did not significantly increase the immune response in HD patients.

CONCLUSIONS

Influenza vaccination in HD patients should be encouraged, but the immune response was comparatively impaired in subpopulations, including patients with a long-term HD history (>2.5 years), with a higher urea reduction rate, or with underlying diabetes. There was no effect of a booster vaccine dose on the antibody titers.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Internal Medicine, Korea University Guro Hospital, Guro Gu, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16699258

Citation

Song, Joon Young, et al. "Active Influenza Immunization in Hemodialysis Patients: Comparison Between Single-dose and Booster Vaccination." American Journal of Nephrology, vol. 26, no. 2, 2006, pp. 206-11.
Song JY, Cheong HJ, Ha SH, et al. Active influenza immunization in hemodialysis patients: comparison between single-dose and booster vaccination. Am J Nephrol. 2006;26(2):206-11.
Song, J. Y., Cheong, H. J., Ha, S. H., Kee, S. Y., Jeong, H. W., & Kim, W. J. (2006). Active influenza immunization in hemodialysis patients: comparison between single-dose and booster vaccination. American Journal of Nephrology, 26(2), pp. 206-11.
Song JY, et al. Active Influenza Immunization in Hemodialysis Patients: Comparison Between Single-dose and Booster Vaccination. Am J Nephrol. 2006;26(2):206-11. PubMed PMID: 16699258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Active influenza immunization in hemodialysis patients: comparison between single-dose and booster vaccination. AU - Song,Joon Young, AU - Cheong,Hee Jin, AU - Ha,Seok Hoon, AU - Kee,Sae Yoon, AU - Jeong,Hye Won, AU - Kim,Woo Joo, Y1 - 2006/05/11/ PY - 2006/02/06/received PY - 2006/04/11/accepted PY - 2006/5/16/pubmed PY - 2006/10/27/medline PY - 2006/5/16/entrez SP - 206 EP - 11 JF - American journal of nephrology JO - Am. J. Nephrol. VL - 26 IS - 2 N2 - BACKGROUND/AIMS: Hemodialysis (HD) patients are recommended to be immunized against influenza annually, but the immune response after vaccination is known to be weakened in these patients. We intended to compare the efficacy of influenza vaccines in HD patients with that in healthy people, and we also evaluated the additive effect of a booster vaccination in HD patients. METHODS: During the 2003-2004 influenza season, 100 patients on HD and 50 age-matched healthy controls were recruited from the Korea University Guro Hospital. The HD patients were divided into two groups: single-dose group (50 patients) and booster group (50 patients). Eight weeks following the influenza vaccination, the serum antibody responses were compared. RESULTS: Although the antibody response of the HD patients was impaired in comparison with that of healthy controls, more than 90% of the HD patients showed protective antibody levels. Booster vaccination did not significantly increase the immune response in HD patients. CONCLUSIONS: Influenza vaccination in HD patients should be encouraged, but the immune response was comparatively impaired in subpopulations, including patients with a long-term HD history (>2.5 years), with a higher urea reduction rate, or with underlying diabetes. There was no effect of a booster vaccine dose on the antibody titers. SN - 0250-8095 UR - https://www.unboundmedicine.com/medline/citation/16699258/Active_influenza_immunization_in_hemodialysis_patients:_comparison_between_single_dose_and_booster_vaccination_ L2 - https://www.karger.com?DOI=10.1159/000093306 DB - PRIME DP - Unbound Medicine ER -