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Apolipoprotein E epsilon4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis.
Dement Geriatr Cogn Disord 2006; 22(1):73-82DG

Abstract

OBJECTIVE

The apolipoprotein E (ApoE) epsilon4 allele is a well-documented genetic risk factor for Alzheimer's disease (AD). Its role, if any, in the progression of cognitive and functional impairment in AD has been the subject of discrepant reports in the literature. This study aimed to determine whether ApoE epsilon4 dose is related to the progression of cognitive and functional decline in AD patients by combined retrospective and prospective analyses.

METHODS

A sample of 366 AD patients was genotyped for ApoE. Subjects received tests of cognition (Mini-Mental State Examination, MMSE; Alzheimer's Disease Assessment Scale-Cognitive subscale, ADAS-Cog) and daily function (Instrumental Activities of Daily Living, IADL; Alzheimer's Disease Cooperative Study-Activities of Daily Living, ADCS-ADL) at baseline and at multiple subsequent time points during their participation in a variety of research protocols. In retrospective analyses, scores on baseline cognitive and functional measures were compared cross-sectionally among genotype groups, controlling for duration of symptoms. In prospective analyses, longitudinal rates of change for each measure were computed by linear regression and compared across genotype groups.

RESULTS

No association was observed between ApoE epsilon4 dose and any of the retrospective or prospective measures of cognitive or functional decline in this AD patient sample.

CONCLUSIONS

Although ApoE epsilon4 increases the risk for AD and decreases the age of disease onset in population studies, it did not significantly influence the rate of disease progression in cognitive or functional domains in our sample.

Authors+Show Affiliations

Alzheimer's Disease Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16699282

Citation

Kleiman, Timothy, et al. "Apolipoprotein E Epsilon4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer's Disease: Retrospective and Prospective Analysis." Dementia and Geriatric Cognitive Disorders, vol. 22, no. 1, 2006, pp. 73-82.
Kleiman T, Zdanys K, Black B, et al. Apolipoprotein E epsilon4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis. Dement Geriatr Cogn Disord. 2006;22(1):73-82.
Kleiman, T., Zdanys, K., Black, B., Rightmer, T., Grey, M., Garman, K., ... van Dyck, C. (2006). Apolipoprotein E epsilon4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis. Dementia and Geriatric Cognitive Disorders, 22(1), pp. 73-82.
Kleiman T, et al. Apolipoprotein E Epsilon4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer's Disease: Retrospective and Prospective Analysis. Dement Geriatr Cogn Disord. 2006;22(1):73-82. PubMed PMID: 16699282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E epsilon4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis. AU - Kleiman,Timothy, AU - Zdanys,Kristina, AU - Black,Benjamin, AU - Rightmer,Tracy, AU - Grey,Monique, AU - Garman,Katherine, AU - Macavoy,Martha, AU - Gelernter,Joel, AU - van Dyck,Christopher, Y1 - 2006/05/12/ PY - 2005/12/20/accepted PY - 2006/5/16/pubmed PY - 2006/8/19/medline PY - 2006/5/16/entrez SP - 73 EP - 82 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 22 IS - 1 N2 - OBJECTIVE: The apolipoprotein E (ApoE) epsilon4 allele is a well-documented genetic risk factor for Alzheimer's disease (AD). Its role, if any, in the progression of cognitive and functional impairment in AD has been the subject of discrepant reports in the literature. This study aimed to determine whether ApoE epsilon4 dose is related to the progression of cognitive and functional decline in AD patients by combined retrospective and prospective analyses. METHODS: A sample of 366 AD patients was genotyped for ApoE. Subjects received tests of cognition (Mini-Mental State Examination, MMSE; Alzheimer's Disease Assessment Scale-Cognitive subscale, ADAS-Cog) and daily function (Instrumental Activities of Daily Living, IADL; Alzheimer's Disease Cooperative Study-Activities of Daily Living, ADCS-ADL) at baseline and at multiple subsequent time points during their participation in a variety of research protocols. In retrospective analyses, scores on baseline cognitive and functional measures were compared cross-sectionally among genotype groups, controlling for duration of symptoms. In prospective analyses, longitudinal rates of change for each measure were computed by linear regression and compared across genotype groups. RESULTS: No association was observed between ApoE epsilon4 dose and any of the retrospective or prospective measures of cognitive or functional decline in this AD patient sample. CONCLUSIONS: Although ApoE epsilon4 increases the risk for AD and decreases the age of disease onset in population studies, it did not significantly influence the rate of disease progression in cognitive or functional domains in our sample. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/16699282/Apolipoprotein_E_epsilon4_allele_is_unrelated_to_cognitive_or_functional_decline_in_Alzheimer's_disease:_retrospective_and_prospective_analysis_ L2 - https://www.karger.com?DOI=10.1159/000093316 DB - PRIME DP - Unbound Medicine ER -