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Concordance rates and modifiable risk factors for lower urinary tract symptoms in twins.
Epidemiology 2006; 17(4):419-27E

Abstract

INTRODUCTION

Lower urinary tract symptoms, which are common in older men, are thought to be determined genetically and by modifiable environmental risk factors. We examined the contribution of these 2 etiologic components in a cohort of U.S. twins.

METHODS

In 1998, a questionnaire that assessed lower urinary tract symptoms, weight, height, alcohol consumption, cigarette smoking, and physical activity was sent out to members of the National Academy of Science-National Research Council Twins Registry. We analyzed 1,723 complete twin pairs with information on lower urinary tract symptoms and zygosity and who did not have a previous diagnosis of prostate cancer. We calculated concordance rates of categories of the International Prostate Symptom Score in monozygotic (MZ) and dizygotic (DZ) twins. Generalized estimating equations were used to calculate the odds ratio of having high-moderate/severe lower urinary tract symptoms.

RESULTS

Concordance rates were higher in MZ than in DZ twins with concordance rate ratios of 2.2 and 6.9 depending on the specificity of definition of symptoms. Genetic factors contributed 72% to the risk of high-moderate/severe lower urinary tract symptoms. Taking into account correlated individuals, we observed high odds of lower urinary tract symptoms in obese men compared with lean men (odds ratio = 1.91; 95% confidence interval = 1.16-3.15 comparing first versus fourth quartile). Cigarette smoking was not associated with lower urinary tract symptoms, but alcohol consumption was positively associated. Men who were more physically active tended to have lower odds of lower urinary tract symptoms compared with less active men (0.62; 0.36-1.08).

CONCLUSION

The findings indicate a strong genetic component of lower urinary tract symptoms, but also support previous studies that modifiable environmental risk factors are associated with this condition.

Authors+Show Affiliations

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

16699472

Citation

Rohrmann, Sabine, et al. "Concordance Rates and Modifiable Risk Factors for Lower Urinary Tract Symptoms in Twins." Epidemiology (Cambridge, Mass.), vol. 17, no. 4, 2006, pp. 419-27.
Rohrmann S, Fallin MD, Page WF, et al. Concordance rates and modifiable risk factors for lower urinary tract symptoms in twins. Epidemiology. 2006;17(4):419-27.
Rohrmann, S., Fallin, M. D., Page, W. F., Reed, T., Partin, A. W., Walsh, P. C., & Platz, E. A. (2006). Concordance rates and modifiable risk factors for lower urinary tract symptoms in twins. Epidemiology (Cambridge, Mass.), 17(4), pp. 419-27.
Rohrmann S, et al. Concordance Rates and Modifiable Risk Factors for Lower Urinary Tract Symptoms in Twins. Epidemiology. 2006;17(4):419-27. PubMed PMID: 16699472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concordance rates and modifiable risk factors for lower urinary tract symptoms in twins. AU - Rohrmann,Sabine, AU - Fallin,M Daniele, AU - Page,William F, AU - Reed,Terry, AU - Partin,Alan W, AU - Walsh,Patrick C, AU - Platz,Elizabeth A, PY - 2006/5/16/pubmed PY - 2006/12/13/medline PY - 2006/5/16/entrez SP - 419 EP - 27 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 17 IS - 4 N2 - INTRODUCTION: Lower urinary tract symptoms, which are common in older men, are thought to be determined genetically and by modifiable environmental risk factors. We examined the contribution of these 2 etiologic components in a cohort of U.S. twins. METHODS: In 1998, a questionnaire that assessed lower urinary tract symptoms, weight, height, alcohol consumption, cigarette smoking, and physical activity was sent out to members of the National Academy of Science-National Research Council Twins Registry. We analyzed 1,723 complete twin pairs with information on lower urinary tract symptoms and zygosity and who did not have a previous diagnosis of prostate cancer. We calculated concordance rates of categories of the International Prostate Symptom Score in monozygotic (MZ) and dizygotic (DZ) twins. Generalized estimating equations were used to calculate the odds ratio of having high-moderate/severe lower urinary tract symptoms. RESULTS: Concordance rates were higher in MZ than in DZ twins with concordance rate ratios of 2.2 and 6.9 depending on the specificity of definition of symptoms. Genetic factors contributed 72% to the risk of high-moderate/severe lower urinary tract symptoms. Taking into account correlated individuals, we observed high odds of lower urinary tract symptoms in obese men compared with lean men (odds ratio = 1.91; 95% confidence interval = 1.16-3.15 comparing first versus fourth quartile). Cigarette smoking was not associated with lower urinary tract symptoms, but alcohol consumption was positively associated. Men who were more physically active tended to have lower odds of lower urinary tract symptoms compared with less active men (0.62; 0.36-1.08). CONCLUSION: The findings indicate a strong genetic component of lower urinary tract symptoms, but also support previous studies that modifiable environmental risk factors are associated with this condition. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/16699472/Concordance_rates_and_modifiable_risk_factors_for_lower_urinary_tract_symptoms_in_twins_ L2 - http://Insights.ovid.com/pubmed?pmid=16699472 DB - PRIME DP - Unbound Medicine ER -