Tags

Type your tag names separated by a space and hit enter

The role of L-arginine in toxic liver failure: interrelation of arginase, polyamine catabolic enzymes and nitric oxide synthase.
Amino Acids. 2007 Jan; 32(1):127-31.AA

Abstract

The existing interrelation in metabolic pathways of L-arginine to polyamines, nitric oxide (NO) and urea synthesis could be affected in sepsis, inflammation, intoxication and other conditions. The role of polyamines and NO in the toxic effect of mercury chloride on rat liver function was studied. Administration of mercury chloride for 24 h led to significantly elevated plasma activities of Alanine transaminase (ALT) and Aspartate transaminase (AST). Malondyaldehyde (MDA) levels were unaffected (p > 0.05) and arginase activity was significantly decreased (p < 0.05) while nitrate/nitrite production was significantly elevated (p < 0.001) in liver tissue. Polyamine oxidase (PAO) and diamine oxidase (DAO) activities, enzymes involved in catabolism of polyamines, were decreased. L-arginine supplementation to intoxicated rats potentiated the effect of mercury chloride on NO production and it was ineffective on arginase activity. Results obtained in this study show that mercury chloride-induced toxicity leads to abnormally high levels of ALT and AST that may indicate liver damage with the involvement of polyamine catabolic enzymes and NO.

Authors+Show Affiliations

Department of Biochemistry, School of Medicine, University of Nis, Nis, Serbia and Montenegro. nikdan@bankerinter.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16699819

Citation

Nikolic, J, et al. "The Role of L-arginine in Toxic Liver Failure: Interrelation of Arginase, Polyamine Catabolic Enzymes and Nitric Oxide Synthase." Amino Acids, vol. 32, no. 1, 2007, pp. 127-31.
Nikolic J, Stojanovic I, Pavlovic R, et al. The role of L-arginine in toxic liver failure: interrelation of arginase, polyamine catabolic enzymes and nitric oxide synthase. Amino Acids. 2007;32(1):127-31.
Nikolic, J., Stojanovic, I., Pavlovic, R., Sokolovic, D., Bjelakovic, G., & Beninati, S. (2007). The role of L-arginine in toxic liver failure: interrelation of arginase, polyamine catabolic enzymes and nitric oxide synthase. Amino Acids, 32(1), 127-31.
Nikolic J, et al. The Role of L-arginine in Toxic Liver Failure: Interrelation of Arginase, Polyamine Catabolic Enzymes and Nitric Oxide Synthase. Amino Acids. 2007;32(1):127-31. PubMed PMID: 16699819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of L-arginine in toxic liver failure: interrelation of arginase, polyamine catabolic enzymes and nitric oxide synthase. AU - Nikolic,J, AU - Stojanovic,I, AU - Pavlovic,R, AU - Sokolovic,D, AU - Bjelakovic,G, AU - Beninati,S, Y1 - 2006/05/15/ PY - 2005/11/17/received PY - 2006/03/02/accepted PY - 2006/5/16/pubmed PY - 2007/12/6/medline PY - 2006/5/16/entrez SP - 127 EP - 31 JF - Amino acids JO - Amino Acids VL - 32 IS - 1 N2 - The existing interrelation in metabolic pathways of L-arginine to polyamines, nitric oxide (NO) and urea synthesis could be affected in sepsis, inflammation, intoxication and other conditions. The role of polyamines and NO in the toxic effect of mercury chloride on rat liver function was studied. Administration of mercury chloride for 24 h led to significantly elevated plasma activities of Alanine transaminase (ALT) and Aspartate transaminase (AST). Malondyaldehyde (MDA) levels were unaffected (p > 0.05) and arginase activity was significantly decreased (p < 0.05) while nitrate/nitrite production was significantly elevated (p < 0.001) in liver tissue. Polyamine oxidase (PAO) and diamine oxidase (DAO) activities, enzymes involved in catabolism of polyamines, were decreased. L-arginine supplementation to intoxicated rats potentiated the effect of mercury chloride on NO production and it was ineffective on arginase activity. Results obtained in this study show that mercury chloride-induced toxicity leads to abnormally high levels of ALT and AST that may indicate liver damage with the involvement of polyamine catabolic enzymes and NO. SN - 0939-4451 UR - https://www.unboundmedicine.com/medline/citation/16699819/The_role_of_L_arginine_in_toxic_liver_failure:_interrelation_of_arginase_polyamine_catabolic_enzymes_and_nitric_oxide_synthase_ L2 - https://dx.doi.org/10.1007/s00726-006-0309-y DB - PRIME DP - Unbound Medicine ER -