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Implication of cannabinoids in neurological diseases.

Abstract

1. Preparations from Cannabis sativa (marijuana) have been used for many centuries both medicinally and recreationally. 2. Recent advances in the knowledge of its pharmacological and chemical properties in the organism, mainly due to Delta(9)-tetrahydrocannabinol, and the physiological roles played by the endocannabinoids have opened up new strategies in the treatment of neurological and psychiatric diseases. 3. Potential therapeutic uses of cannabinoid receptor agonists include the management of spasticity and tremor in multiple sclerosis/spinal cord injury, pain, inflammatory disorders, glaucoma, bronchial asthma, cancer, and vasodilation that accompanies advanced cirrhosis. CB(1) receptor antagonists have therapeutic potential in Parkinson's disease. 4. Dr. Julius Axelrod also contributed in studies on the neuroprotective actions of cannabinoids.

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  • Authors+Show Affiliations

    Dpto. Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Avda. Complutense s/n, Madrid, 28040, Spain. aalsasua@med.ucm.es

    Source

    MeSH

    Animals
    Brain
    Cannabinoid Receptor Modulators
    Cannabinoids
    Central Nervous System Diseases
    Humans
    Neuroprotective Agents
    Receptor, Cannabinoid, CB1

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    16699878

    Citation

    Alsasua del Valle, Angela. "Implication of Cannabinoids in Neurological Diseases." Cellular and Molecular Neurobiology, vol. 26, no. 4-6, 2006, pp. 579-91.
    Alsasua del Valle A. Implication of cannabinoids in neurological diseases. Cell Mol Neurobiol. 2006;26(4-6):579-91.
    Alsasua del Valle, A. (2006). Implication of cannabinoids in neurological diseases. Cellular and Molecular Neurobiology, 26(4-6), pp. 579-91.
    Alsasua del Valle A. Implication of Cannabinoids in Neurological Diseases. Cell Mol Neurobiol. 2006;26(4-6):579-91. PubMed PMID: 16699878.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Implication of cannabinoids in neurological diseases. A1 - Alsasua del Valle,Angela, Y1 - 2006/05/12/ PY - 2006/01/10/received PY - 2006/03/30/accepted PY - 2006/5/16/pubmed PY - 2007/4/25/medline PY - 2006/5/16/entrez SP - 579 EP - 91 JF - Cellular and molecular neurobiology JO - Cell. Mol. Neurobiol. VL - 26 IS - 4-6 N2 - 1. Preparations from Cannabis sativa (marijuana) have been used for many centuries both medicinally and recreationally. 2. Recent advances in the knowledge of its pharmacological and chemical properties in the organism, mainly due to Delta(9)-tetrahydrocannabinol, and the physiological roles played by the endocannabinoids have opened up new strategies in the treatment of neurological and psychiatric diseases. 3. Potential therapeutic uses of cannabinoid receptor agonists include the management of spasticity and tremor in multiple sclerosis/spinal cord injury, pain, inflammatory disorders, glaucoma, bronchial asthma, cancer, and vasodilation that accompanies advanced cirrhosis. CB(1) receptor antagonists have therapeutic potential in Parkinson's disease. 4. Dr. Julius Axelrod also contributed in studies on the neuroprotective actions of cannabinoids. SN - 0272-4340 UR - https://www.unboundmedicine.com/medline/citation/16699878/Implication_of_cannabinoids_in_neurological_diseases_ L2 - https://doi.org/10.1007/s10571-006-9070-8 DB - PRIME DP - Unbound Medicine ER -