Tags

Type your tag names separated by a space and hit enter

Relationships between changes in plasma lipid transfer proteins and apolipoprotein B-100 kinetics during fenofibrate treatment in the metabolic syndrome.
Clin Sci (Lond). 2006 Sep; 111(3):193-9.CS

Abstract

The aim of the present study was to investigate the association between changes in apoB (apolipoprotein B-100) kinetics and plasma PLTP (phospholipid transfer protein) and CETP (cholesteryl ester transfer protein) activities in men with MetS (the metabolic syndrome) treated with fenofibrate. Eleven men with MetS underwent a double-blind cross-over treatment with fenofibrate (200 mg/day) or placebo for 5 weeks. Compared with placebo, fenofibrate significantly increased the FCRs (fractional catabolic rates) of apoB in VLDL (very-low-density lipoprotein), IDL (intermediate-density lipoprotein) and LDL (low-density lipoprotein) (all P<0.01), with no significant reduction (-8%; P=0.131) in VLDL-apoB PR (production rate), but an almost significant increase (+15%, P=0.061) in LDL-apoB PR. Fenofibrate significantly lowered plasma TG [triacylglycerol (triglyceride); P<0.001], the VLDL-TG/apoB ratio (P=0.003) and CETP activity (P=0.004), but increased plasma HDL (high-density lipoprotein)-cholesterol concentration (P<0.001) and PLTP activity (P=0.03). The increase in PLTP activity was positively associated with the increase in both LDL-apoB FCR (r=0.641, P=0.034) and PR (r=0.625, P=0.040), and this was independent of the fall in plasma CETP activity and lathosterol level. The decrease in CETP activity was positively associated with the decrease in VLDL-apoB PR (r=0.615, P=0.044), but this association was not robust and not independent of changes in PLTP activity and lathosterol levels. Hence, in MetS, the effects of fenofibrate on plasma lipid transfer protein activities, especially PLTP activity, may partially explain the associated changes in apoB kinetics.

Authors+Show Affiliations

Lipoprotein Research Unit, School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6000 Australia. gfwatts@cyllene.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16700661

Citation

Watts, Gerald F., et al. "Relationships Between Changes in Plasma Lipid Transfer Proteins and Apolipoprotein B-100 Kinetics During Fenofibrate Treatment in the Metabolic Syndrome." Clinical Science (London, England : 1979), vol. 111, no. 3, 2006, pp. 193-9.
Watts GF, Ji J, Chan DC, et al. Relationships between changes in plasma lipid transfer proteins and apolipoprotein B-100 kinetics during fenofibrate treatment in the metabolic syndrome. Clin Sci (Lond). 2006;111(3):193-9.
Watts, G. F., Ji, J., Chan, D. C., Ooi, E. M., Johnson, A. G., Rye, K. A., & Barrett, P. H. (2006). Relationships between changes in plasma lipid transfer proteins and apolipoprotein B-100 kinetics during fenofibrate treatment in the metabolic syndrome. Clinical Science (London, England : 1979), 111(3), 193-9.
Watts GF, et al. Relationships Between Changes in Plasma Lipid Transfer Proteins and Apolipoprotein B-100 Kinetics During Fenofibrate Treatment in the Metabolic Syndrome. Clin Sci (Lond). 2006;111(3):193-9. PubMed PMID: 16700661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between changes in plasma lipid transfer proteins and apolipoprotein B-100 kinetics during fenofibrate treatment in the metabolic syndrome. AU - Watts,Gerald F, AU - Ji,Juying, AU - Chan,Dick C, AU - Ooi,Esther M M, AU - Johnson,Anthony G, AU - Rye,Kerry-Anne, AU - Barrett,P Hugh R, PY - 2006/5/17/pubmed PY - 2007/1/16/medline PY - 2006/5/17/entrez SP - 193 EP - 9 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 111 IS - 3 N2 - The aim of the present study was to investigate the association between changes in apoB (apolipoprotein B-100) kinetics and plasma PLTP (phospholipid transfer protein) and CETP (cholesteryl ester transfer protein) activities in men with MetS (the metabolic syndrome) treated with fenofibrate. Eleven men with MetS underwent a double-blind cross-over treatment with fenofibrate (200 mg/day) or placebo for 5 weeks. Compared with placebo, fenofibrate significantly increased the FCRs (fractional catabolic rates) of apoB in VLDL (very-low-density lipoprotein), IDL (intermediate-density lipoprotein) and LDL (low-density lipoprotein) (all P<0.01), with no significant reduction (-8%; P=0.131) in VLDL-apoB PR (production rate), but an almost significant increase (+15%, P=0.061) in LDL-apoB PR. Fenofibrate significantly lowered plasma TG [triacylglycerol (triglyceride); P<0.001], the VLDL-TG/apoB ratio (P=0.003) and CETP activity (P=0.004), but increased plasma HDL (high-density lipoprotein)-cholesterol concentration (P<0.001) and PLTP activity (P=0.03). The increase in PLTP activity was positively associated with the increase in both LDL-apoB FCR (r=0.641, P=0.034) and PR (r=0.625, P=0.040), and this was independent of the fall in plasma CETP activity and lathosterol level. The decrease in CETP activity was positively associated with the decrease in VLDL-apoB PR (r=0.615, P=0.044), but this association was not robust and not independent of changes in PLTP activity and lathosterol levels. Hence, in MetS, the effects of fenofibrate on plasma lipid transfer protein activities, especially PLTP activity, may partially explain the associated changes in apoB kinetics. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/16700661/Relationships_between_changes_in_plasma_lipid_transfer_proteins_and_apolipoprotein_B_100_kinetics_during_fenofibrate_treatment_in_the_metabolic_syndrome_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/CS20060072 DB - PRIME DP - Unbound Medicine ER -