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A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression.
Psychol Med. 2006 Aug; 36(8):1141-52.PM

Abstract

BACKGROUND

To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence.

METHOD

Over a 5-year follow-up, we compared psychiatric disorders in four groups of children: (1) offspring of parents with PD plus MD (n=136); (2) offspring of parents with PD without MD (n=27); (3) offspring of parents with MD but without PD (n=53); and (4) offspring of non-PD non-MD parents (n=103).

RESULTS

Parental PD was significantly associated with increased risk for anxiety disorders, irrespective of parental MD. Parental MD was associated with increased risk for MD, disruptive behavior disorders, and deficits in psychosocial functioning, irrespective of parental PD.

CONCLUSIONS

These longitudinal findings confirm and extend previous cross-sectional results documenting significant associations between PD and MD in parents and patterns of psychopathology and dysfunction in their offspring.

Authors+Show Affiliations

Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA. jbiederman@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16700966

Citation

Biederman, Joseph, et al. "A Controlled Longitudinal 5-year Follow-up Study of Children at High and Low Risk for Panic Disorder and Major Depression." Psychological Medicine, vol. 36, no. 8, 2006, pp. 1141-52.
Biederman J, Petty C, Hirshfeld-Becker DR, et al. A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression. Psychol Med. 2006;36(8):1141-52.
Biederman, J., Petty, C., Hirshfeld-Becker, D. R., Henin, A., Faraone, S. V., Dang, D., Jakubowski, A., & Rosenbaum, J. F. (2006). A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression. Psychological Medicine, 36(8), 1141-52.
Biederman J, et al. A Controlled Longitudinal 5-year Follow-up Study of Children at High and Low Risk for Panic Disorder and Major Depression. Psychol Med. 2006;36(8):1141-52. PubMed PMID: 16700966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression. AU - Biederman,Joseph, AU - Petty,Carter, AU - Hirshfeld-Becker,Dina R, AU - Henin,Aude, AU - Faraone,Stephen V, AU - Dang,Danielle, AU - Jakubowski,Aleksandra, AU - Rosenbaum,Jerrold F, Y1 - 2006/05/15/ PY - 2006/5/17/pubmed PY - 2006/12/23/medline PY - 2006/5/17/entrez SP - 1141 EP - 52 JF - Psychological medicine JO - Psychol Med VL - 36 IS - 8 N2 - BACKGROUND: To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence. METHOD: Over a 5-year follow-up, we compared psychiatric disorders in four groups of children: (1) offspring of parents with PD plus MD (n=136); (2) offspring of parents with PD without MD (n=27); (3) offspring of parents with MD but without PD (n=53); and (4) offspring of non-PD non-MD parents (n=103). RESULTS: Parental PD was significantly associated with increased risk for anxiety disorders, irrespective of parental MD. Parental MD was associated with increased risk for MD, disruptive behavior disorders, and deficits in psychosocial functioning, irrespective of parental PD. CONCLUSIONS: These longitudinal findings confirm and extend previous cross-sectional results documenting significant associations between PD and MD in parents and patterns of psychopathology and dysfunction in their offspring. SN - 0033-2917 UR - https://www.unboundmedicine.com/medline/citation/16700966/A_controlled_longitudinal_5_year_follow_up_study_of_children_at_high_and_low_risk_for_panic_disorder_and_major_depression_ L2 - https://www.cambridge.org/core/product/identifier/S0033291706007781/type/journal_article DB - PRIME DP - Unbound Medicine ER -