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A multimicronutrient-fortified seasoning powder enhances the hemoglobin, zinc, and iodine status of primary school children in North East Thailand: a randomized controlled trial of efficacy.
J Nutr. 2006 Jun; 136(6):1617-23.JN

Abstract

Anemia and co-existing deficiencies of zinc, iron, iodine, and vitamin A occur among children in many developing countries including NE Thailand, probably contributing to impairments in growth, immune competence, and cognition. Sustainable strategies are urgently required to combat these deficiencies. We assessed the efficacy of a micronutrient-fortified seasoning powder served with a school lunch on reducing anemia and improving the micronutrient status of rural NE Thai children. Children (n = 569) aged 5.5-13.4y from 10 schools were randomly assigned to receive a seasoning powder either unfortified or fortified with zinc (5 mg), iron (5 mg), vitamin A (270 microg), and iodine (50 microg) (per serving) and incorporated into a school lunch prepared centrally and delivered 5 d/wk for 31 wk. Teachers monitored school lunch consumption. Baseline and final micronutrient status, hemoglobinopathies, and infection or inflammation were assessed from blood and urine samples. For the primary outcome, anemia (based on hemoglobin), no intervention effect was apparent (odds ratio: 1.02 95% CI: 0.69, 1.51) after adjustment for design strata. The odds of zinc (based on serum zinc) and urinary iodine deficiency in the fortified group were 0.63 (0.42, 0.94) and 0.52 (0.38, 0.71) times those in the unfortified group, respectively. Fortification had no effect on serum retinol (0.61: 0.25,1.51), ferritin (1.12: 0.43, 2.96), or mean red cell volume (1.16: 0.82, 1.64). Therefore, a micronutrient-fortified seasoning powder is a promising vehicle for improving zinc, iodine, and hemoglobin status, and its potential for incorporation into lunch programs in day care centers and schools in NE Thailand warrants investigation.

Authors+Show Affiliations

Institute of Nutrition, Mahidol University, Salaya, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16702330

Citation

Winichagoon, Pattanee, et al. "A Multimicronutrient-fortified Seasoning Powder Enhances the Hemoglobin, Zinc, and Iodine Status of Primary School Children in North East Thailand: a Randomized Controlled Trial of Efficacy." The Journal of Nutrition, vol. 136, no. 6, 2006, pp. 1617-23.
Winichagoon P, McKenzie JE, Chavasit V, et al. A multimicronutrient-fortified seasoning powder enhances the hemoglobin, zinc, and iodine status of primary school children in North East Thailand: a randomized controlled trial of efficacy. J Nutr. 2006;136(6):1617-23.
Winichagoon, P., McKenzie, J. E., Chavasit, V., Pongcharoen, T., Gowachirapant, S., Boonpraderm, A., Manger, M. S., Bailey, K. B., Wasantwisut, E., & Gibson, R. S. (2006). A multimicronutrient-fortified seasoning powder enhances the hemoglobin, zinc, and iodine status of primary school children in North East Thailand: a randomized controlled trial of efficacy. The Journal of Nutrition, 136(6), 1617-23.
Winichagoon P, et al. A Multimicronutrient-fortified Seasoning Powder Enhances the Hemoglobin, Zinc, and Iodine Status of Primary School Children in North East Thailand: a Randomized Controlled Trial of Efficacy. J Nutr. 2006;136(6):1617-23. PubMed PMID: 16702330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A multimicronutrient-fortified seasoning powder enhances the hemoglobin, zinc, and iodine status of primary school children in North East Thailand: a randomized controlled trial of efficacy. AU - Winichagoon,Pattanee, AU - McKenzie,Joanne E, AU - Chavasit,Visith, AU - Pongcharoen,Tippawan, AU - Gowachirapant,Sueppong, AU - Boonpraderm,Atitada, AU - Manger,Mari S, AU - Bailey,Karl B, AU - Wasantwisut,Emorn, AU - Gibson,Rosalind S, PY - 2006/5/17/pubmed PY - 2006/6/23/medline PY - 2006/5/17/entrez SP - 1617 EP - 23 JF - The Journal of nutrition JO - J. Nutr. VL - 136 IS - 6 N2 - Anemia and co-existing deficiencies of zinc, iron, iodine, and vitamin A occur among children in many developing countries including NE Thailand, probably contributing to impairments in growth, immune competence, and cognition. Sustainable strategies are urgently required to combat these deficiencies. We assessed the efficacy of a micronutrient-fortified seasoning powder served with a school lunch on reducing anemia and improving the micronutrient status of rural NE Thai children. Children (n = 569) aged 5.5-13.4y from 10 schools were randomly assigned to receive a seasoning powder either unfortified or fortified with zinc (5 mg), iron (5 mg), vitamin A (270 microg), and iodine (50 microg) (per serving) and incorporated into a school lunch prepared centrally and delivered 5 d/wk for 31 wk. Teachers monitored school lunch consumption. Baseline and final micronutrient status, hemoglobinopathies, and infection or inflammation were assessed from blood and urine samples. For the primary outcome, anemia (based on hemoglobin), no intervention effect was apparent (odds ratio: 1.02 95% CI: 0.69, 1.51) after adjustment for design strata. The odds of zinc (based on serum zinc) and urinary iodine deficiency in the fortified group were 0.63 (0.42, 0.94) and 0.52 (0.38, 0.71) times those in the unfortified group, respectively. Fortification had no effect on serum retinol (0.61: 0.25,1.51), ferritin (1.12: 0.43, 2.96), or mean red cell volume (1.16: 0.82, 1.64). Therefore, a micronutrient-fortified seasoning powder is a promising vehicle for improving zinc, iodine, and hemoglobin status, and its potential for incorporation into lunch programs in day care centers and schools in NE Thailand warrants investigation. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/16702330/A_multimicronutrient_fortified_seasoning_powder_enhances_the_hemoglobin_zinc_and_iodine_status_of_primary_school_children_in_North_East_Thailand:_a_randomized_controlled_trial_of_efficacy_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/136.6.1617 DB - PRIME DP - Unbound Medicine ER -