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Perinatal risk factors for cancer of the esophagus and gastric cardia: a nested case-control study.
Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):867-71.CE

Abstract

BACKGROUND

We have previously hypothesized that preterm birth or impaired fetal growth may cause esophageal adenocarcinomas through gastroesophageal reflux early in life. In this study, we aimed to test if there is an association between gestational duration and birth weight on the one hand, and risk of esophageal and cardia adenocarcinoma on the other.

METHODS

We conducted a nested case-control study of 67 cases of esophageal adenocarcinoma and 93 cases of cardia adenocarcinoma, whereas 50 cases of squamous cell carcinoma were studied for comparison. Birth records of cases were traced. Three matched controls per case were randomly selected. Perinatal data were extracted from birth records.

RESULTS

Long gestational duration was associated with a decreased risk of cardia adenocarcinoma (P(trend) = 0.001) and a nonsignificant decreased risk of esophageal adenocarcinoma (P = 0.07), whereas no such association was found for esophageal squamous cell carcinoma (P = 0.96). Birth weight was not associated with risk of any of the studied cancers. Compared with lower maternal age (</=24 years) at giving birth, maternal age of 25 to 29 years were associated with a decreased risk of esophageal adenocarcinoma and squamous cell carcinoma (odds ratio, 0.4; 95% confidence interval, 0.2-0.9 and odds ratio, 0.3; 95% confidence interval, 0.1-0.8, respectively).

CONCLUSIONS

Numerical constraints hamper inference, but our results are somewhat consistent with the idea that future risk of esophageal and cardia cancer may in part be determined already perinatally or in infancy and give some limited support to the hypothesis that timing of birth influences risk.

Authors+Show Affiliations

Clinical Epidemiology Unit, Karolinska University Hospital, Solna, M9:01, SE-171 76 Stockholm, Sweden. olof.akre@medks.ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16702362

Citation

Akre, Olof, et al. "Perinatal Risk Factors for Cancer of the Esophagus and Gastric Cardia: a Nested Case-control Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 15, no. 5, 2006, pp. 867-71.
Akre O, Forssell L, Kaijser M, et al. Perinatal risk factors for cancer of the esophagus and gastric cardia: a nested case-control study. Cancer Epidemiol Biomarkers Prev. 2006;15(5):867-71.
Akre, O., Forssell, L., Kaijser, M., Norén-Nilsson, I., Lagergren, J., Nyrén, O., & Ekbom, A. (2006). Perinatal risk factors for cancer of the esophagus and gastric cardia: a nested case-control study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 15(5), 867-71.
Akre O, et al. Perinatal Risk Factors for Cancer of the Esophagus and Gastric Cardia: a Nested Case-control Study. Cancer Epidemiol Biomarkers Prev. 2006;15(5):867-71. PubMed PMID: 16702362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal risk factors for cancer of the esophagus and gastric cardia: a nested case-control study. AU - Akre,Olof, AU - Forssell,Lina, AU - Kaijser,Magnus, AU - Norén-Nilsson,Ingrid, AU - Lagergren,Jesper, AU - Nyrén,Olof, AU - Ekbom,Anders, PY - 2006/5/17/pubmed PY - 2006/10/27/medline PY - 2006/5/17/entrez SP - 867 EP - 71 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 15 IS - 5 N2 - BACKGROUND: We have previously hypothesized that preterm birth or impaired fetal growth may cause esophageal adenocarcinomas through gastroesophageal reflux early in life. In this study, we aimed to test if there is an association between gestational duration and birth weight on the one hand, and risk of esophageal and cardia adenocarcinoma on the other. METHODS: We conducted a nested case-control study of 67 cases of esophageal adenocarcinoma and 93 cases of cardia adenocarcinoma, whereas 50 cases of squamous cell carcinoma were studied for comparison. Birth records of cases were traced. Three matched controls per case were randomly selected. Perinatal data were extracted from birth records. RESULTS: Long gestational duration was associated with a decreased risk of cardia adenocarcinoma (P(trend) = 0.001) and a nonsignificant decreased risk of esophageal adenocarcinoma (P = 0.07), whereas no such association was found for esophageal squamous cell carcinoma (P = 0.96). Birth weight was not associated with risk of any of the studied cancers. Compared with lower maternal age (</=24 years) at giving birth, maternal age of 25 to 29 years were associated with a decreased risk of esophageal adenocarcinoma and squamous cell carcinoma (odds ratio, 0.4; 95% confidence interval, 0.2-0.9 and odds ratio, 0.3; 95% confidence interval, 0.1-0.8, respectively). CONCLUSIONS: Numerical constraints hamper inference, but our results are somewhat consistent with the idea that future risk of esophageal and cardia cancer may in part be determined already perinatally or in infancy and give some limited support to the hypothesis that timing of birth influences risk. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16702362/Perinatal_risk_factors_for_cancer_of_the_esophagus_and_gastric_cardia:_a_nested_case_control_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=16702362 DB - PRIME DP - Unbound Medicine ER -