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Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancer.
Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):946-54.CE

Abstract

BACKGROUND

Important differences in the contributions of certain exposures to the risks of ductal versus lobular breast carcinomas have been observed, but few studies have evaluated the relationships between established breast cancer risk factors and other histologic types.

METHODS

Information on family history of cancer and reproductive, hormonal, anthropometric, and lifestyle characteristics were collected in a multicenter population-based case-control study consisting of 3,463 ductal, 274 lobular, 261 ductal-lobular, 91 medullary, 77 tubular, 70 comedo, and 61 mucinous invasive breast carcinoma cases (ages 35-64 years, newly diagnosed 1994-1998) and 4,682 controls. Associations between each of these histologic types and various exposures were evaluated using polytomous regression.

RESULTS

Heterogeneity in the risks of different histologic types of breast cancer was observed for three exposures: menopausal hormone use, body mass index (BMI), and alcohol consumption. Specifically, current use of unopposed estrogen was associated with a reduced risk of ductal carcinoma and increased risk of comedocarcinoma, and current use of estrogen and progestin was associated with elevated risks of ductal-lobular and tubular carcinomas. Among postmenopausal women, BMI was only inversely related to risk of ductal-lobular carcinoma, and alcohol use was only positively related to risk of lobular carcinoma.

CONCLUSIONS

Variations in the associations between known breast cancer risk factors and risk of different breast cancer histologies were observed. Although these findings require confirmation, and the analyses of some histologic groups were limited by small sample sizes, they provide some insight into the different etiologies of various histologic subtypes of breast cancer.

Authors+Show Affiliations

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4-C308, P.O. Box 19024, Seattle, WA 98109-1024, USA. cili@fhcrc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16702375

Citation

Li, Christopher I., et al. "Relationship Between Established Breast Cancer Risk Factors and Risk of Seven Different Histologic Types of Invasive Breast Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 15, no. 5, 2006, pp. 946-54.
Li CI, Daling JR, Malone KE, et al. Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancer. Cancer Epidemiol Biomarkers Prev. 2006;15(5):946-54.
Li, C. I., Daling, J. R., Malone, K. E., Bernstein, L., Marchbanks, P. A., Liff, J. M., Strom, B. L., Simon, M. S., Press, M. F., McDonald, J. A., Ursin, G., Burkman, R. T., Deapen, D., & Spirtas, R. (2006). Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 15(5), 946-54.
Li CI, et al. Relationship Between Established Breast Cancer Risk Factors and Risk of Seven Different Histologic Types of Invasive Breast Cancer. Cancer Epidemiol Biomarkers Prev. 2006;15(5):946-54. PubMed PMID: 16702375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancer. AU - Li,Christopher I, AU - Daling,Janet R, AU - Malone,Kathleen E, AU - Bernstein,Leslie, AU - Marchbanks,Polly A, AU - Liff,Jonathan M, AU - Strom,Brian L, AU - Simon,Michael S, AU - Press,Michael F, AU - McDonald,Jill A, AU - Ursin,Giske, AU - Burkman,Ronald T, AU - Deapen,Dennis, AU - Spirtas,Robert, PY - 2006/5/17/pubmed PY - 2006/10/27/medline PY - 2006/5/17/entrez SP - 946 EP - 54 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 15 IS - 5 N2 - BACKGROUND: Important differences in the contributions of certain exposures to the risks of ductal versus lobular breast carcinomas have been observed, but few studies have evaluated the relationships between established breast cancer risk factors and other histologic types. METHODS: Information on family history of cancer and reproductive, hormonal, anthropometric, and lifestyle characteristics were collected in a multicenter population-based case-control study consisting of 3,463 ductal, 274 lobular, 261 ductal-lobular, 91 medullary, 77 tubular, 70 comedo, and 61 mucinous invasive breast carcinoma cases (ages 35-64 years, newly diagnosed 1994-1998) and 4,682 controls. Associations between each of these histologic types and various exposures were evaluated using polytomous regression. RESULTS: Heterogeneity in the risks of different histologic types of breast cancer was observed for three exposures: menopausal hormone use, body mass index (BMI), and alcohol consumption. Specifically, current use of unopposed estrogen was associated with a reduced risk of ductal carcinoma and increased risk of comedocarcinoma, and current use of estrogen and progestin was associated with elevated risks of ductal-lobular and tubular carcinomas. Among postmenopausal women, BMI was only inversely related to risk of ductal-lobular carcinoma, and alcohol use was only positively related to risk of lobular carcinoma. CONCLUSIONS: Variations in the associations between known breast cancer risk factors and risk of different breast cancer histologies were observed. Although these findings require confirmation, and the analyses of some histologic groups were limited by small sample sizes, they provide some insight into the different etiologies of various histologic subtypes of breast cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16702375/Relationship_between_established_breast_cancer_risk_factors_and_risk_of_seven_different_histologic_types_of_invasive_breast_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16702375 DB - PRIME DP - Unbound Medicine ER -