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Review of the abdominal manifestations of cystic fibrosis in the adult patient.
Radiographics 2006 May-Jun; 26(3):679-90R

Abstract

Cystic fibrosis is a common inherited fatal disease. As the life expectancy of affected individuals continues to increase with advances in disease management, this disease is no longer limited to the pediatric population. Currently, 40% of patients with cystic fibrosis are adults. In addition, patients may not present until adulthood and frequently have extrapulmonary symptoms. Abdominal manifestations are common and affect multiple organ systems. Hepatobiliary manifestations include fatty infiltration of the liver, gallbladder abnormalities, bile duct abnormalities, focal biliary fibrosis, and multinodular cirrhosis. Manifestations in the pancreas include acute pancreatitis, fatty replacement, calcifications, cysts, duct abnormalities, and carcinoma. Gastrointestinal manifestations include gastroesophageal reflux, peptic ulceration of the gastric and duodenal mucosa, distal intestinal obstruction syndrome, intussusception, appendicitis, fibrosing colonopathy, pneumatosis intestinalis, rectal mucosal prolapse, malignancies, and pseudomembranous colitis. Renal manifestations include nephrolithiasis, as well as secondary renal complications such as interstitial nephritis due to antibiotic therapy and amyloidosis. Awareness of these manifestations is important to successfully guide management of cystic fibrosis in adult patients.

Authors+Show Affiliations

Department of Radiology, University of Cincinnati, 234 Goodman St, ML 0761, Cincinnati, OH 45267-0761, USANo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16702447

Citation

Robertson, Michael B., et al. "Review of the Abdominal Manifestations of Cystic Fibrosis in the Adult Patient." Radiographics : a Review Publication of the Radiological Society of North America, Inc, vol. 26, no. 3, 2006, pp. 679-90.
Robertson MB, Choe KA, Joseph PM. Review of the abdominal manifestations of cystic fibrosis in the adult patient. Radiographics. 2006;26(3):679-90.
Robertson, M. B., Choe, K. A., & Joseph, P. M. (2006). Review of the abdominal manifestations of cystic fibrosis in the adult patient. Radiographics : a Review Publication of the Radiological Society of North America, Inc, 26(3), pp. 679-90.
Robertson MB, Choe KA, Joseph PM. Review of the Abdominal Manifestations of Cystic Fibrosis in the Adult Patient. Radiographics. 2006;26(3):679-90. PubMed PMID: 16702447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review of the abdominal manifestations of cystic fibrosis in the adult patient. AU - Robertson,Michael B, AU - Choe,Kyuran A, AU - Joseph,Patricia M, PY - 2006/5/17/pubmed PY - 2006/9/6/medline PY - 2006/5/17/entrez SP - 679 EP - 90 JF - Radiographics : a review publication of the Radiological Society of North America, Inc JO - Radiographics VL - 26 IS - 3 N2 - Cystic fibrosis is a common inherited fatal disease. As the life expectancy of affected individuals continues to increase with advances in disease management, this disease is no longer limited to the pediatric population. Currently, 40% of patients with cystic fibrosis are adults. In addition, patients may not present until adulthood and frequently have extrapulmonary symptoms. Abdominal manifestations are common and affect multiple organ systems. Hepatobiliary manifestations include fatty infiltration of the liver, gallbladder abnormalities, bile duct abnormalities, focal biliary fibrosis, and multinodular cirrhosis. Manifestations in the pancreas include acute pancreatitis, fatty replacement, calcifications, cysts, duct abnormalities, and carcinoma. Gastrointestinal manifestations include gastroesophageal reflux, peptic ulceration of the gastric and duodenal mucosa, distal intestinal obstruction syndrome, intussusception, appendicitis, fibrosing colonopathy, pneumatosis intestinalis, rectal mucosal prolapse, malignancies, and pseudomembranous colitis. Renal manifestations include nephrolithiasis, as well as secondary renal complications such as interstitial nephritis due to antibiotic therapy and amyloidosis. Awareness of these manifestations is important to successfully guide management of cystic fibrosis in adult patients. SN - 1527-1323 UR - https://www.unboundmedicine.com/medline/citation/16702447/Review_of_the_abdominal_manifestations_of_cystic_fibrosis_in_the_adult_patient_ L2 - http://pubs.rsna.org/doi/10.1148/rg.263055101?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -