Tags

Type your tag names separated by a space and hit enter

Regulation of the actin cytoskeleton by PIP2 in cytokinesis.
Biol Cell 2006; 98(6):377-88BC

Abstract

Cytokinesis is a sequential process that occurs in three phases: assembly of the cytokinetic apparatus, furrow progression and fission (abscission) of the newly formed daughter cells. The ingression of the cleavage furrow is dependent on the constriction of an equatorial actomyosin ring in many cell types. Recent studies have demonstrated that this structure is highly dynamic and undergoes active polymerization and depolymerization throughout the furrowing process. Despite much progress in the identification of contractile ring components, little is known regarding the mechanism of its assembly and structural rearrangements. PIP2 (phosphatidylinositol 4,5-bisphosphate) is a critical regulator of actin dynamics and plays an essential role in cell motility and adhesion. Recent studies have indicated that an elevation of PIP2 at the cleavage furrow is a critical event for furrow stability. In this review we discuss the role of PIP2-mediated signalling in the structural maintenance of the contractile ring and furrow progression. In addition, we address the role of other phosphoinositides, PI(4)P (phosphatidylinositol 4-phosphate) and PIP3 (phosphatidylinositol 3,4,5-triphosphate) in these processes.

Authors+Show Affiliations

Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 2B2.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16704377

Citation

Logan, Michael R., and Craig A. Mandato. "Regulation of the Actin Cytoskeleton By PIP2 in Cytokinesis." Biology of the Cell, vol. 98, no. 6, 2006, pp. 377-88.
Logan MR, Mandato CA. Regulation of the actin cytoskeleton by PIP2 in cytokinesis. Biol Cell. 2006;98(6):377-88.
Logan, M. R., & Mandato, C. A. (2006). Regulation of the actin cytoskeleton by PIP2 in cytokinesis. Biology of the Cell, 98(6), pp. 377-88.
Logan MR, Mandato CA. Regulation of the Actin Cytoskeleton By PIP2 in Cytokinesis. Biol Cell. 2006;98(6):377-88. PubMed PMID: 16704377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of the actin cytoskeleton by PIP2 in cytokinesis. AU - Logan,Michael R, AU - Mandato,Craig A, PY - 2006/5/18/pubmed PY - 2006/9/15/medline PY - 2006/5/18/entrez SP - 377 EP - 88 JF - Biology of the cell JO - Biol. Cell VL - 98 IS - 6 N2 - Cytokinesis is a sequential process that occurs in three phases: assembly of the cytokinetic apparatus, furrow progression and fission (abscission) of the newly formed daughter cells. The ingression of the cleavage furrow is dependent on the constriction of an equatorial actomyosin ring in many cell types. Recent studies have demonstrated that this structure is highly dynamic and undergoes active polymerization and depolymerization throughout the furrowing process. Despite much progress in the identification of contractile ring components, little is known regarding the mechanism of its assembly and structural rearrangements. PIP2 (phosphatidylinositol 4,5-bisphosphate) is a critical regulator of actin dynamics and plays an essential role in cell motility and adhesion. Recent studies have indicated that an elevation of PIP2 at the cleavage furrow is a critical event for furrow stability. In this review we discuss the role of PIP2-mediated signalling in the structural maintenance of the contractile ring and furrow progression. In addition, we address the role of other phosphoinositides, PI(4)P (phosphatidylinositol 4-phosphate) and PIP3 (phosphatidylinositol 3,4,5-triphosphate) in these processes. SN - 0248-4900 UR - https://www.unboundmedicine.com/medline/citation/16704377/Regulation_of_the_actin_cytoskeleton_by_PIP2_in_cytokinesis_ L2 - https://doi.org/10.1042/BC20050081 DB - PRIME DP - Unbound Medicine ER -