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Resting energy expenditure in patients with solid tumors undergoing anticancer therapy.
Nutrition. 2006 Jun; 22(6):609-15.N

Abstract

OBJECTIVE

Few studies have investigated the resting energy expenditure (REE) of, or determined the individual predictive accuracy of prediction equations in, cancer patients undergoing anticancer therapy. This study compared the measured REE of patients with cancer undergoing anticancer therapy with (1) healthy subjects and (2) REE estimated from commonly used prediction methods.

METHODS

Resting energy expenditure was measured in 18 cancer patients and 17 healthy subjects by using indirect calorimetry under standard conditions and was estimated from seven prediction methods. Fat-free mass (FFM) was measured by bioelectrical impedance analysis. Data were analyzed with regression modeling to adjust REE for FFM. Agreement between measured and predicted REE values was analyzed using the Bland-Altman approach.

RESULTS

There was no significant difference in FFM-adjusted REE between cancer patients and healthy subjects (mean difference 10%). Limits of agreement were wide for all prediction methods in estimating REE as much as 40% below and up to 30% above measured REE.

CONCLUSIONS

REE in cancer patients undergoing anticancer therapies does not appear to be as high as commonly thought. None of the prediction equations examined were acceptable for predicting REE of individual cancer patients or healthy subjects.

Authors+Show Affiliations

Centre for Health Research, School of Public Health, Queensland University of Technology, Brisbane, Queensland, Australia. mreeves@qldcancer.com.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16704954

Citation

Reeves, Marina M., et al. "Resting Energy Expenditure in Patients With Solid Tumors Undergoing Anticancer Therapy." Nutrition (Burbank, Los Angeles County, Calif.), vol. 22, no. 6, 2006, pp. 609-15.
Reeves MM, Battistutta D, Capra S, et al. Resting energy expenditure in patients with solid tumors undergoing anticancer therapy. Nutrition. 2006;22(6):609-15.
Reeves, M. M., Battistutta, D., Capra, S., Bauer, J., & Davies, P. S. (2006). Resting energy expenditure in patients with solid tumors undergoing anticancer therapy. Nutrition (Burbank, Los Angeles County, Calif.), 22(6), 609-15.
Reeves MM, et al. Resting Energy Expenditure in Patients With Solid Tumors Undergoing Anticancer Therapy. Nutrition. 2006;22(6):609-15. PubMed PMID: 16704954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resting energy expenditure in patients with solid tumors undergoing anticancer therapy. AU - Reeves,Marina M, AU - Battistutta,Diana, AU - Capra,Sandra, AU - Bauer,Judy, AU - Davies,Peter S W, PY - 2005/04/29/received PY - 2005/12/07/revised PY - 2006/03/17/accepted PY - 2006/5/18/pubmed PY - 2006/10/27/medline PY - 2006/5/18/entrez SP - 609 EP - 15 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 22 IS - 6 N2 - OBJECTIVE: Few studies have investigated the resting energy expenditure (REE) of, or determined the individual predictive accuracy of prediction equations in, cancer patients undergoing anticancer therapy. This study compared the measured REE of patients with cancer undergoing anticancer therapy with (1) healthy subjects and (2) REE estimated from commonly used prediction methods. METHODS: Resting energy expenditure was measured in 18 cancer patients and 17 healthy subjects by using indirect calorimetry under standard conditions and was estimated from seven prediction methods. Fat-free mass (FFM) was measured by bioelectrical impedance analysis. Data were analyzed with regression modeling to adjust REE for FFM. Agreement between measured and predicted REE values was analyzed using the Bland-Altman approach. RESULTS: There was no significant difference in FFM-adjusted REE between cancer patients and healthy subjects (mean difference 10%). Limits of agreement were wide for all prediction methods in estimating REE as much as 40% below and up to 30% above measured REE. CONCLUSIONS: REE in cancer patients undergoing anticancer therapies does not appear to be as high as commonly thought. None of the prediction equations examined were acceptable for predicting REE of individual cancer patients or healthy subjects. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16704954/Resting_energy_expenditure_in_patients_with_solid_tumors_undergoing_anticancer_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(06)00152-3 DB - PRIME DP - Unbound Medicine ER -