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Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle.
Learn Mem. 2006 May-Jun; 13(3):316-21.LM

Abstract

The cannabinoid CB1 receptor has been shown to be critically involved in the extinction of fear memory. Systemic injection of a CB1 receptor antagonist prior to extinction training blocked extinction. Conversely, administration of the cannabinoid uptake inhibitor AM404 facilitated extinction in a dose-dependent manner. Here we show that bilateral infusion of CB1 receptor agonists into the amygdala after memory reactivation blocked reconsolidation of fear memory measured with fear-potentiated startle. The effect was dose-dependent and could be blocked by AM251, a specific CB1 receptor antagonist. In contrast, the effect of CB1 agonists on reconsolidation was no longer seen if memory reactivation was omitted. Concomitant with block of reconsolidation, CB1 agonist-treated animals did not exhibit shock-induced reinstatement or spontaneous recovery of fear. The absence of recovery was not attributable to permanent damage to the amygdala in WIN-treated rats, nor did the effect result from alteration of baseline startle or shock reactivity. These results suggest that CB1 agonists could impair fear memory via blocking reconsolidation.

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Authors+Show Affiliations

Lin HC
Institute of Basic Medical Sciences and Department of Pharmacology, National Cheng-Kung University, Tainan, Taiwan. bailu@mail.nih.gov
Mao SC
No affiliation info available
Gean PW
No affiliation info available

MeSH

AmygdalaAnalysis of VarianceAnimalsArachidonic AcidsAssociation LearningBenzoxazinesCannabinoidsConditioning, ClassicalDose-Response Relationship, DrugDronabinolExtinction, PsychologicalFearMemoryMicroinjectionsMorpholinesNaphthalenesPiperidinesPyrazolesRatsReceptor, Cannabinoid, CB1Reflex, Startle

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16705137

Citation

Lin, Hui-Ching, et al. "Effects of Intra-amygdala Infusion of CB1 Receptor Agonists On the Reconsolidation of Fear-potentiated Startle." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 13, no. 3, 2006, pp. 316-21.
Lin HC, Mao SC, Gean PW. Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle. Learn Mem. 2006;13(3):316-21.
Lin, H. C., Mao, S. C., & Gean, P. W. (2006). Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle. Learning & Memory (Cold Spring Harbor, N.Y.), 13(3), 316-21.
Lin HC, Mao SC, Gean PW. Effects of Intra-amygdala Infusion of CB1 Receptor Agonists On the Reconsolidation of Fear-potentiated Startle. Learn Mem. 2006 May-Jun;13(3):316-21. PubMed PMID: 16705137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle. AU - Lin,Hui-Ching, AU - Mao,Sheng-Chun, AU - Gean,Po-Wu, Y1 - 2006/05/16/ PY - 2006/5/18/pubmed PY - 2006/8/24/medline PY - 2006/5/18/entrez SP - 316 EP - 21 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 13 IS - 3 N2 - The cannabinoid CB1 receptor has been shown to be critically involved in the extinction of fear memory. Systemic injection of a CB1 receptor antagonist prior to extinction training blocked extinction. Conversely, administration of the cannabinoid uptake inhibitor AM404 facilitated extinction in a dose-dependent manner. Here we show that bilateral infusion of CB1 receptor agonists into the amygdala after memory reactivation blocked reconsolidation of fear memory measured with fear-potentiated startle. The effect was dose-dependent and could be blocked by AM251, a specific CB1 receptor antagonist. In contrast, the effect of CB1 agonists on reconsolidation was no longer seen if memory reactivation was omitted. Concomitant with block of reconsolidation, CB1 agonist-treated animals did not exhibit shock-induced reinstatement or spontaneous recovery of fear. The absence of recovery was not attributable to permanent damage to the amygdala in WIN-treated rats, nor did the effect result from alteration of baseline startle or shock reactivity. These results suggest that CB1 agonists could impair fear memory via blocking reconsolidation. SN - 1072-0502 UR - https://www.unboundmedicine.com/medline/citation/16705137/Effects_of_intra_amygdala_infusion_of_CB1_receptor_agonists_on_the_reconsolidation_of_fear_potentiated_startle_ DB - PRIME DP - Unbound Medicine ER -