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A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS.
Physiol Meas. 2006 Jul; 27(7):637-48.PM

Abstract

Selected ion flow tube mass spectrometry, SIFT-MS, has been used to monitor the volatile compounds in the exhaled breath of 30 volunteers (19 male, 11 female) over a six-month period. Volunteers provided breath samples each week between 8:45 am and 1 pm (before lunch), and the concentrations of several trace compounds were obtained. In this paper the focus is on methanol in breath. The median methanol level determined using the H(3)O(+) precursor ions for all samples was 461 parts-per-billion (ppb), the concentrations for all the samples ranging from 32 to 1684 ppb. The distribution of breath methanol concentration is seen to be log-normal for this healthy population; the geometric mean was 450 ppb, close to the median value, and the multiplicative (geometric) standard deviation was 1.62. Breath methanol is not correlated with age, breath ethanol or ethanol consumed in the previous 24 h, but there was an inverse correlation with body mass index (BMI) for the cohort of volunteers recruited for this study. Observed breath methanol levels are well compatible with the previously published blood methanol levels. Some tentative suggestions are made concerning the origin of endogenous methanol.

Authors+Show Affiliations

Cranfield University, Silsoe, Bedford, MK45 4DT, UK. c.turner@cranfield.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16705261

Citation

Turner, Claire, et al. "A Longitudinal Study of Methanol in the Exhaled Breath of 30 Healthy Volunteers Using Selected Ion Flow Tube Mass Spectrometry, SIFT-MS." Physiological Measurement, vol. 27, no. 7, 2006, pp. 637-48.
Turner C, Spanel P, Smith D. A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS. Physiol Meas. 2006;27(7):637-48.
Turner, C., Spanel, P., & Smith, D. (2006). A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS. Physiological Measurement, 27(7), 637-48.
Turner C, Spanel P, Smith D. A Longitudinal Study of Methanol in the Exhaled Breath of 30 Healthy Volunteers Using Selected Ion Flow Tube Mass Spectrometry, SIFT-MS. Physiol Meas. 2006;27(7):637-48. PubMed PMID: 16705261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS. AU - Turner,Claire, AU - Spanel,Patrik, AU - Smith,David, Y1 - 2006/05/03/ PY - 2006/5/18/pubmed PY - 2006/9/29/medline PY - 2006/5/18/entrez SP - 637 EP - 48 JF - Physiological measurement JO - Physiol Meas VL - 27 IS - 7 N2 - Selected ion flow tube mass spectrometry, SIFT-MS, has been used to monitor the volatile compounds in the exhaled breath of 30 volunteers (19 male, 11 female) over a six-month period. Volunteers provided breath samples each week between 8:45 am and 1 pm (before lunch), and the concentrations of several trace compounds were obtained. In this paper the focus is on methanol in breath. The median methanol level determined using the H(3)O(+) precursor ions for all samples was 461 parts-per-billion (ppb), the concentrations for all the samples ranging from 32 to 1684 ppb. The distribution of breath methanol concentration is seen to be log-normal for this healthy population; the geometric mean was 450 ppb, close to the median value, and the multiplicative (geometric) standard deviation was 1.62. Breath methanol is not correlated with age, breath ethanol or ethanol consumed in the previous 24 h, but there was an inverse correlation with body mass index (BMI) for the cohort of volunteers recruited for this study. Observed breath methanol levels are well compatible with the previously published blood methanol levels. Some tentative suggestions are made concerning the origin of endogenous methanol. SN - 0967-3334 UR - https://www.unboundmedicine.com/medline/citation/16705261/A_longitudinal_study_of_methanol_in_the_exhaled_breath_of_30_healthy_volunteers_using_selected_ion_flow_tube_mass_spectrometry_SIFT_MS_ L2 - https://doi.org/10.1088/0967-3334/27/7/007 DB - PRIME DP - Unbound Medicine ER -