Tags

Type your tag names separated by a space and hit enter

L-DOPA-induced dyskinesia in adult rats with a unilateral 6-OHDA lesion of dopamine neurons is paralleled by increased c-fos gene expression in the subthalamic nucleus.
Eur J Neurosci. 2006 May; 23(9):2395-403.EJ

Abstract

Levodopa (L-DOPA), the metabolic precursor of dopamine, is widely used as a pharmacological agent for the symptomatic treatment of Parkinson's disease. However, long-term L-DOPA use results in abnormal involuntary movements such as dyskinesias. There is evidence that abnormal cell signaling in the basal ganglia is involved in L-DOPA-induced dyskinesia. The subthalamic nucleus (STN) plays a key role in the circuitry of the basal ganglia and in the pathophysiology of Parkinson's disease. However, the contribution of the STN to L-DOPA-induced dyskinesias remains unclear. The objective of this work was to study the effects of acute or chronic systemic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of dopamine neurons on c-fos expression in the STN and test the hypothesis that these effects correlate with L-DOPA-induced dyskinesias. c-fos mRNA expression was measured in the STN by in situ hybridization histochemistry at the single cell level. Our results confirm earlier evidence that the chronic administration of L-DOPA to rats with a unilateral 6-OHDA lesion increases c-fos expression in the STN. We also report that c-fos expression can be increased following an acute injection of L-DOPA to 6-OHDA-lesioned rats but not following a chronic injection of L-DOPA to sham-operated, unlesioned rats. Finally, we provide evidence that the occurrence and severity of dyskinesia is correlated with c-fos mRNA levels in the ipsilateral STN. These results suggest that altered cell signaling in the STN is involved in some of the behavioral effects induced by systemic L-DOPA administration.

Authors+Show Affiliations

Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA. jjsogho@bu.edu

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16706847

Citation

Soghomonian, Jean-Jacques. "L-DOPA-induced Dyskinesia in Adult Rats With a Unilateral 6-OHDA Lesion of Dopamine Neurons Is Paralleled By Increased C-fos Gene Expression in the Subthalamic Nucleus." The European Journal of Neuroscience, vol. 23, no. 9, 2006, pp. 2395-403.
Soghomonian JJ. L-DOPA-induced dyskinesia in adult rats with a unilateral 6-OHDA lesion of dopamine neurons is paralleled by increased c-fos gene expression in the subthalamic nucleus. Eur J Neurosci. 2006;23(9):2395-403.
Soghomonian, J. J. (2006). L-DOPA-induced dyskinesia in adult rats with a unilateral 6-OHDA lesion of dopamine neurons is paralleled by increased c-fos gene expression in the subthalamic nucleus. The European Journal of Neuroscience, 23(9), 2395-403.
Soghomonian JJ. L-DOPA-induced Dyskinesia in Adult Rats With a Unilateral 6-OHDA Lesion of Dopamine Neurons Is Paralleled By Increased C-fos Gene Expression in the Subthalamic Nucleus. Eur J Neurosci. 2006;23(9):2395-403. PubMed PMID: 16706847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - L-DOPA-induced dyskinesia in adult rats with a unilateral 6-OHDA lesion of dopamine neurons is paralleled by increased c-fos gene expression in the subthalamic nucleus. A1 - Soghomonian,Jean-Jacques, PY - 2006/5/19/pubmed PY - 2006/10/7/medline PY - 2006/5/19/entrez SP - 2395 EP - 403 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 23 IS - 9 N2 - Levodopa (L-DOPA), the metabolic precursor of dopamine, is widely used as a pharmacological agent for the symptomatic treatment of Parkinson's disease. However, long-term L-DOPA use results in abnormal involuntary movements such as dyskinesias. There is evidence that abnormal cell signaling in the basal ganglia is involved in L-DOPA-induced dyskinesia. The subthalamic nucleus (STN) plays a key role in the circuitry of the basal ganglia and in the pathophysiology of Parkinson's disease. However, the contribution of the STN to L-DOPA-induced dyskinesias remains unclear. The objective of this work was to study the effects of acute or chronic systemic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of dopamine neurons on c-fos expression in the STN and test the hypothesis that these effects correlate with L-DOPA-induced dyskinesias. c-fos mRNA expression was measured in the STN by in situ hybridization histochemistry at the single cell level. Our results confirm earlier evidence that the chronic administration of L-DOPA to rats with a unilateral 6-OHDA lesion increases c-fos expression in the STN. We also report that c-fos expression can be increased following an acute injection of L-DOPA to 6-OHDA-lesioned rats but not following a chronic injection of L-DOPA to sham-operated, unlesioned rats. Finally, we provide evidence that the occurrence and severity of dyskinesia is correlated with c-fos mRNA levels in the ipsilateral STN. These results suggest that altered cell signaling in the STN is involved in some of the behavioral effects induced by systemic L-DOPA administration. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/16706847/L_DOPA_induced_dyskinesia_in_adult_rats_with_a_unilateral_6_OHDA_lesion_of_dopamine_neurons_is_paralleled_by_increased_c_fos_gene_expression_in_the_subthalamic_nucleus_ L2 - https://doi.org/10.1111/j.1460-9568.2006.04758.x DB - PRIME DP - Unbound Medicine ER -