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Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease.
Biochem Biophys Res Commun. 2006 Jul 07; 345(3):967-72.BB

Abstract

DJ-1 is an antioxidant protein whose loss of function by gene mutations has been linked to familial Parkinson's disease (PD). The main objective of the present study was to determine if this molecule was also involved in the pathogenesis of sporadic PD. For this purpose, quantitative immunoblot assays were performed to evaluate DJ-1 in cerebrospinal fluids (CSF) collected from sporadic PD patients (n=40) and non-PD controls (n=38). The results showed that the CSF DJ-1 levels in PD were significantly higher than those in non-PD controls. Especially, upregulation of CSF DJ-1 in the early stage of PD (Yahr I-II) were distinct compared to those in the advanced stage of PD (Yahr III-IV) and non-PD controls (p<0.001 by ANOVA with post hoc Bonferroni's test), suggesting a protective role of DJ-1 against oxidative stress during the early stage. Thus, we propose that CSF DJ-1 could be a possible biomarker for early sporadic PD.

Authors+Show Affiliations

Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183-8526, Japan. warawaram2002@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16707095

Citation

Waragai, Masaaki, et al. "Increased Level of DJ-1 in the Cerebrospinal Fluids of Sporadic Parkinson's Disease." Biochemical and Biophysical Research Communications, vol. 345, no. 3, 2006, pp. 967-72.
Waragai M, Wei J, Fujita M, et al. Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease. Biochem Biophys Res Commun. 2006;345(3):967-72.
Waragai, M., Wei, J., Fujita, M., Nakai, M., Ho, G. J., Masliah, E., Akatsu, H., Yamada, T., & Hashimoto, M. (2006). Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease. Biochemical and Biophysical Research Communications, 345(3), 967-72.
Waragai M, et al. Increased Level of DJ-1 in the Cerebrospinal Fluids of Sporadic Parkinson's Disease. Biochem Biophys Res Commun. 2006 Jul 7;345(3):967-72. PubMed PMID: 16707095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease. AU - Waragai,Masaaki, AU - Wei,Jianshe, AU - Fujita,Masayo, AU - Nakai,Masaaki, AU - Ho,Gilbert J, AU - Masliah,Eliezer, AU - Akatsu,Hiroyasu, AU - Yamada,Tatsuo, AU - Hashimoto,Makoto, Y1 - 2006/05/11/ PY - 2006/04/24/received PY - 2006/05/03/accepted PY - 2006/5/19/pubmed PY - 2006/8/2/medline PY - 2006/5/19/entrez SP - 967 EP - 72 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 345 IS - 3 N2 - DJ-1 is an antioxidant protein whose loss of function by gene mutations has been linked to familial Parkinson's disease (PD). The main objective of the present study was to determine if this molecule was also involved in the pathogenesis of sporadic PD. For this purpose, quantitative immunoblot assays were performed to evaluate DJ-1 in cerebrospinal fluids (CSF) collected from sporadic PD patients (n=40) and non-PD controls (n=38). The results showed that the CSF DJ-1 levels in PD were significantly higher than those in non-PD controls. Especially, upregulation of CSF DJ-1 in the early stage of PD (Yahr I-II) were distinct compared to those in the advanced stage of PD (Yahr III-IV) and non-PD controls (p<0.001 by ANOVA with post hoc Bonferroni's test), suggesting a protective role of DJ-1 against oxidative stress during the early stage. Thus, we propose that CSF DJ-1 could be a possible biomarker for early sporadic PD. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16707095/Increased_level_of_DJ_1_in_the_cerebrospinal_fluids_of_sporadic_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(06)01052-7 DB - PRIME DP - Unbound Medicine ER -