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The cortisol awakening response is blunted in psychotherapy inpatients suffering from depression.
Psychoneuroendocrinology. 2006 Aug; 31(7):900-4.P

Abstract

Determining the salivary awakening cortisol response (ACR) is a non-invasive, reliable method to detect changes in the hypothalamus-hypopituitary-adrenal (HPA) axis. Although a role of the HPA axis in depression is widely recognized, data on the ACR in depressive patients are still scarce and inconsistent. The present study assessed the ACR in depressed patients admitted for inpatient psychotherapy and a comparison group of other psychiatric diagnoses under the same conditions. The ACR was found to be attenuated in depressed as compared to non-depressed patients. This finding is in contrast to previous studies in healthy subjects or depressed outpatients and suggests a blunted rather than an exacerbated HPA reactivity. Further studies will be needed to disentangle the complex relationship between depression and the ACR.

Authors+Show Affiliations

Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. t.j.huber@gmx.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16707227

Citation

Huber, Thomas J., et al. "The Cortisol Awakening Response Is Blunted in Psychotherapy Inpatients Suffering From Depression." Psychoneuroendocrinology, vol. 31, no. 7, 2006, pp. 900-4.
Huber TJ, Issa K, Schik G, et al. The cortisol awakening response is blunted in psychotherapy inpatients suffering from depression. Psychoneuroendocrinology. 2006;31(7):900-4.
Huber, T. J., Issa, K., Schik, G., & Wolf, O. T. (2006). The cortisol awakening response is blunted in psychotherapy inpatients suffering from depression. Psychoneuroendocrinology, 31(7), 900-4.
Huber TJ, et al. The Cortisol Awakening Response Is Blunted in Psychotherapy Inpatients Suffering From Depression. Psychoneuroendocrinology. 2006;31(7):900-4. PubMed PMID: 16707227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cortisol awakening response is blunted in psychotherapy inpatients suffering from depression. AU - Huber,Thomas J, AU - Issa,Katharina, AU - Schik,Gesa, AU - Wolf,Oliver T, Y1 - 2006/05/16/ PY - 2006/02/01/received PY - 2006/03/20/revised PY - 2006/03/24/accepted PY - 2006/5/19/pubmed PY - 2006/9/29/medline PY - 2006/5/19/entrez SP - 900 EP - 4 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 31 IS - 7 N2 - Determining the salivary awakening cortisol response (ACR) is a non-invasive, reliable method to detect changes in the hypothalamus-hypopituitary-adrenal (HPA) axis. Although a role of the HPA axis in depression is widely recognized, data on the ACR in depressive patients are still scarce and inconsistent. The present study assessed the ACR in depressed patients admitted for inpatient psychotherapy and a comparison group of other psychiatric diagnoses under the same conditions. The ACR was found to be attenuated in depressed as compared to non-depressed patients. This finding is in contrast to previous studies in healthy subjects or depressed outpatients and suggests a blunted rather than an exacerbated HPA reactivity. Further studies will be needed to disentangle the complex relationship between depression and the ACR. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/16707227/The_cortisol_awakening_response_is_blunted_in_psychotherapy_inpatients_suffering_from_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(06)00054-0 DB - PRIME DP - Unbound Medicine ER -