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National Veterans Health Administration hospitalizations for syncope compared to acute myocardial infarction, fracture, or pneumonia in community-dwelling elders: outpatient medication and comorbidity profiles.
J Clin Pharmacol. 2006 Jun; 46(6):613-9.JC

Abstract

The authors used 2 national Veterans Health Administration databases to identify outpatient medications and all 30 Elixhauser comorbidities for 2579 unique patients, age 65+ years, hospitalized for syncope in fiscal year 2004. For comparison, we identified other elderly patients hospitalized with acute myocardial infarction (N = 4491), fracture (N = 2797), or pneumonia (N = 9473). The categories of medications included drugs that affect the cardiovascular, central nervous, or the muscular skeletal system. The most notable differences between syncope compared to acute myocardial infarction patients occurred in central nervous system drugs in anticonvulsants/barbiturates, antidepressants, antihistamine/antinauseants, antipsychotics, and cholinesterase inhibitors (P < .0018). Comparing syncope patients with fracture patients, the central nervous medication profile was similar, but the cardiovascular medication profile differed (P < .0018); their hypertension comorbidities also differed (60.45% vs 46.34%); (P < .0016). These findings indicate significant potential associations that warrant further study. Studies linking national outpatient medications to hospitalizations for specific conditions can foster the development of more proactive pharmacovigilance systems.

Authors+Show Affiliations

VISN-8 Patient Safety Center, 13000 Bruce B. Downs Blvd. (118M), Tampa, FL 33612, USA. Dustin.French@med.va.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16707407

Citation

French, Dustin D., et al. "National Veterans Health Administration Hospitalizations for Syncope Compared to Acute Myocardial Infarction, Fracture, or Pneumonia in Community-dwelling Elders: Outpatient Medication and Comorbidity Profiles." Journal of Clinical Pharmacology, vol. 46, no. 6, 2006, pp. 613-9.
French DD, Campbell R, Spehar A, et al. National Veterans Health Administration hospitalizations for syncope compared to acute myocardial infarction, fracture, or pneumonia in community-dwelling elders: outpatient medication and comorbidity profiles. J Clin Pharmacol. 2006;46(6):613-9.
French, D. D., Campbell, R., Spehar, A., Rubenstein, L. Z., Accomando, J., & Cunningham, F. (2006). National Veterans Health Administration hospitalizations for syncope compared to acute myocardial infarction, fracture, or pneumonia in community-dwelling elders: outpatient medication and comorbidity profiles. Journal of Clinical Pharmacology, 46(6), 613-9.
French DD, et al. National Veterans Health Administration Hospitalizations for Syncope Compared to Acute Myocardial Infarction, Fracture, or Pneumonia in Community-dwelling Elders: Outpatient Medication and Comorbidity Profiles. J Clin Pharmacol. 2006;46(6):613-9. PubMed PMID: 16707407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - National Veterans Health Administration hospitalizations for syncope compared to acute myocardial infarction, fracture, or pneumonia in community-dwelling elders: outpatient medication and comorbidity profiles. AU - French,Dustin D, AU - Campbell,Robert, AU - Spehar,Andrea, AU - Rubenstein,Laurence Z, AU - Accomando,John, AU - Cunningham,Francesca, PY - 2006/5/19/pubmed PY - 2006/11/7/medline PY - 2006/5/19/entrez SP - 613 EP - 9 JF - Journal of clinical pharmacology JO - J Clin Pharmacol VL - 46 IS - 6 N2 - The authors used 2 national Veterans Health Administration databases to identify outpatient medications and all 30 Elixhauser comorbidities for 2579 unique patients, age 65+ years, hospitalized for syncope in fiscal year 2004. For comparison, we identified other elderly patients hospitalized with acute myocardial infarction (N = 4491), fracture (N = 2797), or pneumonia (N = 9473). The categories of medications included drugs that affect the cardiovascular, central nervous, or the muscular skeletal system. The most notable differences between syncope compared to acute myocardial infarction patients occurred in central nervous system drugs in anticonvulsants/barbiturates, antidepressants, antihistamine/antinauseants, antipsychotics, and cholinesterase inhibitors (P < .0018). Comparing syncope patients with fracture patients, the central nervous medication profile was similar, but the cardiovascular medication profile differed (P < .0018); their hypertension comorbidities also differed (60.45% vs 46.34%); (P < .0016). These findings indicate significant potential associations that warrant further study. Studies linking national outpatient medications to hospitalizations for specific conditions can foster the development of more proactive pharmacovigilance systems. SN - 0091-2700 UR - https://www.unboundmedicine.com/medline/citation/16707407/National_Veterans_Health_Administration_hospitalizations_for_syncope_compared_to_acute_myocardial_infarction_fracture_or_pneumonia_in_community_dwelling_elders:_outpatient_medication_and_comorbidity_profiles_ L2 - https://doi.org/10.1177/0091270006288452 DB - PRIME DP - Unbound Medicine ER -