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Cutaneous manifestations in patients with chronic renal failure on hemodialysis.
Indian J Dermatol Venereol Leprol 2006 Mar-Apr; 72(2):119-25IJ

Abstract

BACKGROUND

Chronic renal failure (CRF) presents with an array of cutaneous manifestations. Newer changes are being described since the advent of hemodialysis, which prolongs the life expectancy, giving time for these changes to manifest.

AIM

The aim of this study was to evaluate the prevalence of dermatologic problems among patients with chronic renal failure (CRF) undergoing hemodialysis.

METHODS

One hundred patients with CRF on hemodialysis were examined for cutaneous changes.

RESULTS

Eighty-two per cent patients complained of some skin problem. However, on examination, all patients had at least one skin lesion attributable to CRF. The most prevalent finding was xerosis (79%), followed by pallor (60%), pruritus (53%) and cutaneous pigmentation (43%). Other cutaneous manifestations included Kyrle's disease (21%); fungal (30%), bacterial (13%) and viral (12%) infections; uremic frost (3%); purpura (9%); gynecomastia (1%); and dermatitis (2%). The nail changes included half and half nail (21%), koilonychia (18%), onychomycosis (19%), subungual hyperkeratosis (12%), onycholysis (10%), splinter hemorrhages (5%), Mees' lines (7%), Muehrcke's lines (5%) and Beau's lines (2%). Hair changes included sparse body hair (30%), sparse scalp hair (11%) and brittle and lusterless hair (16%). Oral changes included macroglossia with teeth markings (35%), xerostomia (31%), ulcerative stomatitis (29%), angular cheilitis (12%) and uremic breath (8%). Some rare manifestations of CRF like uremic frost, gynecomastia and pseudo-Kaposi's sarcoma were also observed.

CONCLUSIONS

CRF is associated with a complex array of cutaneous manifestations caused either by the disease or by treatment. The commonest are xerosis and pruritus and the early recognition of cutaneous signs can relieve suffering and decrease morbidity.

Authors+Show Affiliations

Department of Dermatology, PSG Hospitals, Peelamedu, Coimbatore, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16707817

Citation

Udayakumar, P, et al. "Cutaneous Manifestations in Patients With Chronic Renal Failure On Hemodialysis." Indian Journal of Dermatology, Venereology and Leprology, vol. 72, no. 2, 2006, pp. 119-25.
Udayakumar P, Balasubramanian S, Ramalingam KS, et al. Cutaneous manifestations in patients with chronic renal failure on hemodialysis. Indian J Dermatol Venereol Leprol. 2006;72(2):119-25.
Udayakumar, P., Balasubramanian, S., Ramalingam, K. S., Lakshmi, C., Srinivas, C. R., & Mathew, A. C. (2006). Cutaneous manifestations in patients with chronic renal failure on hemodialysis. Indian Journal of Dermatology, Venereology and Leprology, 72(2), pp. 119-25.
Udayakumar P, et al. Cutaneous Manifestations in Patients With Chronic Renal Failure On Hemodialysis. Indian J Dermatol Venereol Leprol. 2006;72(2):119-25. PubMed PMID: 16707817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous manifestations in patients with chronic renal failure on hemodialysis. AU - Udayakumar,P, AU - Balasubramanian,S, AU - Ramalingam,K S, AU - Lakshmi,Chembolli, AU - Srinivas,C R, AU - Mathew,Anil C, PY - 2006/5/19/pubmed PY - 2006/10/27/medline PY - 2006/5/19/entrez SP - 119 EP - 25 JF - Indian journal of dermatology, venereology and leprology JO - Indian J Dermatol Venereol Leprol VL - 72 IS - 2 N2 - BACKGROUND: Chronic renal failure (CRF) presents with an array of cutaneous manifestations. Newer changes are being described since the advent of hemodialysis, which prolongs the life expectancy, giving time for these changes to manifest. AIM: The aim of this study was to evaluate the prevalence of dermatologic problems among patients with chronic renal failure (CRF) undergoing hemodialysis. METHODS: One hundred patients with CRF on hemodialysis were examined for cutaneous changes. RESULTS: Eighty-two per cent patients complained of some skin problem. However, on examination, all patients had at least one skin lesion attributable to CRF. The most prevalent finding was xerosis (79%), followed by pallor (60%), pruritus (53%) and cutaneous pigmentation (43%). Other cutaneous manifestations included Kyrle's disease (21%); fungal (30%), bacterial (13%) and viral (12%) infections; uremic frost (3%); purpura (9%); gynecomastia (1%); and dermatitis (2%). The nail changes included half and half nail (21%), koilonychia (18%), onychomycosis (19%), subungual hyperkeratosis (12%), onycholysis (10%), splinter hemorrhages (5%), Mees' lines (7%), Muehrcke's lines (5%) and Beau's lines (2%). Hair changes included sparse body hair (30%), sparse scalp hair (11%) and brittle and lusterless hair (16%). Oral changes included macroglossia with teeth markings (35%), xerostomia (31%), ulcerative stomatitis (29%), angular cheilitis (12%) and uremic breath (8%). Some rare manifestations of CRF like uremic frost, gynecomastia and pseudo-Kaposi's sarcoma were also observed. CONCLUSIONS: CRF is associated with a complex array of cutaneous manifestations caused either by the disease or by treatment. The commonest are xerosis and pruritus and the early recognition of cutaneous signs can relieve suffering and decrease morbidity. SN - 0378-6323 UR - https://www.unboundmedicine.com/medline/citation/16707817/Cutaneous_manifestations_in_patients_with_chronic_renal_failure_on_hemodialysis_ L2 - http://www.ijdvl.com/article.asp?issn=0378-6323;year=2006;volume=72;issue=2;spage=119;epage=125;aulast=Udayakumar DB - PRIME DP - Unbound Medicine ER -